Temporal analysis of the rat's behavior in the plus-maze: effect of midazolam

Rosa, V.P; Vandresen, N; Calixto, A.V.; Kovaleski, D.F; Faria, Moacir Serralvo

doi:10.1016/s0091-3057(00)00316-6

Cited by 26 publications

(14 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Falter, Gower, & Gobert, 1992;Lister, 1987;Rosa, Vandresen, Calixto, Kovaleski, & Faria, 2000;Treit, Menard, & Royan, 1993). This model has been validated in previous research studies (Pellow, Chopin, File, & Briley, 1985).…”

Section: Epm Apparatusmentioning

confidence: 75%

“…The EPM was used to evaluate the amount of anxietylike behavior experienced by the rat (H. Falter, Persinger, & Chretien, 1992;Rosa et al, 2000;Shepherd, Grewal, Fletcher, Bill, & Dourish, 1994;Treit et al, 1993). During the 5-minute test, the number of entries into the open or closed arms, as well as the time spent in each arm, was a measure of anxiety-like behavior.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Tetrahydropalmatine (THP) on PTSD-induced Changes in Rat Neurobehavior

Ceremuga¹,

Anderson²,

Frye³

et al. 2014

Plant Sci Today

View full text Add to dashboard Cite

The purpose of this study was to investigate tetrahydropalmatine (THP), a major compound in Corydalis yanhusuo WT Wang (Family: Papaveraceae) and its effects on PTSD induced neurobehavior in the rodent model. The aims were to determine the effects of THP on anxiety, locomotion, and memory. A prospective experimental between groups design was used. Eighty rats were randomly divided into two groups, nonstressed and stressed. They were then randomly subdivided into four groups: control, THP, midazolam, or THP and midazolam. The behavioral component was evaluated using the elevated plus maze (EPM) and Morris water maze (MWM) in a restraint/shock stress model. Data analysis was performed using a two-tailed Multivariate Analysis of Variance (MANOVA) and LSD post-hoc test. There were significant differences in anxiety between the groups (P<0.05). The PTSD stressed rat groups had significantly reduced time on the open arms of the EPM demonstrating significant increased anxiety compared to the control nonstressed groups. Data pertaining to the MWM did not demonstrate

show abstract

Section: Epm Apparatusmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Effects of Tetrahydropalmatine (THP) on PTSD-induced Changes in Rat Neurobehavior

Ceremuga¹,

Anderson²,

Frye³

et al. 2014

Plant Sci Today

View full text Add to dashboard Cite

show abstract

“…Rosa et at. (2000) [58] revealed that the reduction in motor activity and enclosed arm entries exhibit a considerable level of anxiety. In this study, the number of entries into open arms, and enclosed arms demonstrated the anxiolytic-like effect of harmine that corresponds with all measures revealing the anxiolytic-like effect of harmine during each phase.…”

Section: Discussionmentioning

confidence: 99%

ESTIMATION OF THE ANXIOLYTIC-LIKE EFFECT OF THE Β-Carboline ALKALOID HARMINE ON STRESSED PREGNANT RATS

Benatoui

Bairi

Tahraoui

2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: During the last decade, the role of the β-carboline alkaloid harmine has essentially been studied with regard to its anxiolytic effect, as it was done in our laboratory; therefore, this study has been progressed to cover the effect of this alkaloid on pregnant wistar rats. Methods:The molecule was used at doses of 10 mg/kg, 15 mg/kg, pregnant female rats were divided into three groups according to the stage of pregnancy: first, second, and the third week of pregnancy. Each group has been subdivided into seven subgroups: control group, two treated groups with harmine, acute footshock stress at 1,2mA, sub-acute footshock stress at 0,4mA, psychological stress, and the treated group that footshocked after with 1,2mA, all groups were carried out open field test, plus maze test and light/dark box test. Results:Thigmotaxis is reflected by the significant increase in the traveled distance in peripheral area in the open field of the three groups 'weeks' at dose of 10 mg/kg, the enhancement in the number and time of rearing, at both doses, during the second and the last week, the significant increase in the number of entries 'in open arms' in plus-maze during the first and third weeks at 15 mg/kg, and the significant decreased in time spent in the light compartment of the light/dark box at the same dose of all groups 'weeks' were noticed, which confirm the anxiolytic effect of the alkaloid, even in the case of the footschock stressed pregnant rats of all groups 'weeks' that enhancement of number of enties into open arms during the plus maze test. Conclusion:So we can conclude that the anxiolytic effect of harmine not shortening to male rats, but expands to female pregnant wistar rats, and establishes its effect by diminishing time in light compartment of light/dark box and number of entries in open arms of plus maze, in other hand, the increase in the number and the time of rearing reflects the enhancement of exploratory behavior.

show abstract

“…However, our theoretical framework and experimental model was validated through our implemented controls. The EPM was used to evaluate the amount of anxiety-like behavior experienced by the rat (Lister, 1987;Falter et al, 1992;Treit et al, 1993;Shepherd et al, 1994;Rosa et al, 2000). During the 5-minute test, the number of entries into the open or closed arms, as well as the time spent in each arm, was a measure of anxiety-like behavior.…”

Section: Discussionmentioning

confidence: 99%

“…The EPM is an instrument utilized to measure anxiety in the rodent model (Lister, 1987;Falter et al, 1992;Treit et al, 1993;Shepherd et al, 1994;Rosa et al, 2000). This model has been validated in previous research studies (Montgomery, 1955;Pellow et al, 1985).…”

Section: Elevated Plus Mazementioning

confidence: 99%

Investigation of Effects of L-Theanine on PTSD-induced Changes in Rat Neurobehavior

et al. 2015

View full text Add to dashboard Cite

Temporal analysis of the rat's behavior in the plus-maze: effect of midazolam

Cited by 26 publications

References 18 publications

Effects of Tetrahydropalmatine (THP) on PTSD-induced Changes in Rat Neurobehavior

Effects of Tetrahydropalmatine (THP) on PTSD-induced Changes in Rat Neurobehavior

ESTIMATION OF THE ANXIOLYTIC-LIKE EFFECT OF THE Β-Carboline ALKALOID HARMINE ON STRESSED PREGNANT RATS

Investigation of Effects of L-Theanine on PTSD-induced Changes in Rat Neurobehavior

Contact Info

Product

Resources

About