Temporal and regional patterns of Smad activation in the rat hippocampus following global ischemia

Nakajima, Takayuki; Yanagihara, Masafumi; Nishii, Hideki

doi:10.1016/j.jns.2013.11.012

Cited by 7 publications

(1 citation statement)

References 45 publications

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“…We also noted a strong expression of smad1 in the zebrafish equivalent of the mammalian hippocampus. In rat, Smad expression is also detected in the hippocampus and SMAD proteins are activated following ischemia (Nakajima et al, ). This further underscores the proposition that the DLZ in the zebrafish telencephalon is indeed homologous to the mammalian hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches

Diotel

Viales

Armant

et al. 2015

J of Comparative Neurology

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The zebrafish has become a model to study adult vertebrate neurogenesis. In particular, the adult telencephalon has been an intensely studied structure in the zebrafish brain. Differential expression of transcriptional regulators (TRs) is a key feature of development and tissue homeostasis. Here we report an expression map of 1,202 TR genes in the telencephalon of adult zebrafish. Our results are summarized in a database with search and clustering functions to identify genes expressed in particular regions of the telencephalon. We classified 562 genes into 13 distinct patterns, including genes expressed in the proliferative zone. The remaining 640 genes displayed unique and complex patterns of expression and could thus not be grouped into distinct classes. The neurogenic ventricular regions express overlapping but distinct sets of TR genes, suggesting regional differences in the neurogenic niches in the telencephalon. In summary, the small telencephalon of the zebrafish shows a remarkable complexity in TR gene expression.The adult zebrafish telencephalon has become a model to study neurogenesis. We established the expression pattern of more than 1200 transcription regulators (TR) in the adult telencephalon. The neurogenic regions express overlapping but distinct sets of TR genes suggesting regional differences in the neurogenic potential. J. Comp. Neurol. 523:1202–1221, 2015. © 2015 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%