Temporal and right frontal lobe alterations in panic disorder: a quantitative volumetric and voxel-based morphometric MRI study

Sobanski, Thomas; Wagner, Gerd; Peikert, Gregor; Gruhn, U.; Schluttig, K.; Sauer, Heinrich; Schlößer, R.

doi:10.1017/s0033291709991930

Cited by 64 publications

(33 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides healthy individuals, structural abnormalities in the OFC have been found in patients with affective (Bremner et al, 2002;Lacerda et al, 2004) and anxiety disorders (Hayano et al, 2009;Roppongi et al, 2010;Sobanski et al, 2010). A reduced regional brain volume in the OFC has been related to reduced gyrification and anxiety-related traits in panic disorder (Roppongi et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Individual differences in the Behavioral Inhibition System are associated with orbitofrontal cortex and precuneus gray matter volume

Fuentes

Barrós‐Loscertales

Bustamante

et al. 2012

Cogn Affect Behav Neurosci

View full text Add to dashboard Cite

The Behavioral Inhibition System (BIS) is described in Gray's Reinforcement Sensitivity Theory as a hypothetical construct that mediates anxiety in animals and humans. The neuroanatomical correlates of this system are not fully clear, although they are known to involve the amygdala, the septohippocampal system, and the prefrontal cortex. Previous neuroimaging research has related individual differences in BIS with regional volume and functional variations in the prefrontal cortex, amygdala, and hippocampal formation. The aim of the present work was to study BIS-related individual differences and their relationship with brain regional volume. BIS sensitivity was assessed through the BIS/BAS questionnaire in a sample of male participants (N 0 114), and the scores were correlated with brain regional volume in a voxel-based morphometry analysis. The results show a negative correlation between the BIS and the volume of the right and medial orbitofrontal cortices and the precuneus. Our results and previous findings suggest that individual differences in anxiety-related personality traits and their related psychopathology may be associated with reduced brain volume in certain structures relating to emotional control (i.e., the orbitofrontal cortex) and self-consciousness (i.e., the precuneus), as shown by our results.

show abstract

Section: Discussionmentioning

confidence: 99%

Individual differences in the Behavioral Inhibition System are associated with orbitofrontal cortex and precuneus gray matter volume

Fuentes

Barrós‐Loscertales

Bustamante

et al. 2012

Cogn Affect Behav Neurosci

View full text Add to dashboard Cite

show abstract

“…[24][25][26] Damage to similar regions are also seen in the patients with panic disorders. [27][28][29][30] Lastly, hypercapnia may play a role based on the evidence that panic attack can be provoked by inhalation of carbon dioxide. 31 The strengths of our study are its nationwide, population-based study design and that all respiratory and psychiatric practices were covered in the database, which allowed us to trace all cases of newly diagnosed sleep apnea and panic disorder.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Sleep Apnea and Risk of Panic Disorder

Chen

Lin

et al. 2015

The Annals of Family Medicine

View full text Add to dashboard Cite

PURPOSE Epidemiological studies have identified a trend in the development of depressive and anxiety disorders following a diagnosis of sleep apnea. The relationship between sleep apnea and subsequent panic disorder, however, remains unclear.METHODS Using a nationwide database, the Taiwan National Health Insurance Research Database, patients with sleep apnea and age-, sex-, income-, and urbanization-matched control patients who did not have sleep apnea were enrolled between 2000 and 2010. Patients with a prior diagnosis of panic disorder before enrollment were excluded. The 2 cohorts were observed until December 31, 2010. The primary endpoint was occurrence of newly diagnosed panic disorder.RESULTS A total of 8,704 sleep apnea patients and 34,792 control patients were enrolled. Of the 43,496 patients, 263 (0.60%) suffered from panic disorder during a mean follow-up period of 3.92 years, including 117 (1.34%) from the sleep apnea cohort and 146 (0.42%) from the control group. The Kaplan-Meier analysis revealed a predisposition of patients with sleep apnea to develop panic disorder (log-rank test, P <.001). After multivariate adjustment, the hazard ratio for subsequent panic disorder among the sleep apnea patients was 2.17 (95% confidence interval, 1.68-2.81; P <.001).CONCLUSIONS Sleep apnea appears to confer a higher risk for future development of panic disorder. INTRODUCTIONO bstructive sleep apnea is a common disorder characterized by repeated episodes of apnea and hypopnea during sleep owing to complete or partial collapse of the upper airway.1 Subsequent to apnea/hypopnea, patients with sleep apnea will be awakened by the resulting hypoxemia so that they can resume breathing. Some patients may awake up feeling like they are choking or suffocating, thereby increasing their sense of stress. In the past decade obstructive sleep apnea has been found to be linked to a variety of cardiovascular diseases, neurocognitive dysfunction, and behavioral disorders. 2,3Patients with sleep apnea may also have substantial comorbid mental disorders, such as depression, anxiety, bipolar disorder, schizophrenia, post-traumatic stress syndrome, and substance abuse. 4 Panic disorder is an extreme pole of anxiety disorder with features of recurrent panic attacks. There are, however, few studies addressing the relationship between sleep apnea and panic disorder, and most of these studies are small or lack an appropriate control group.5-9 A crossover study enrolling 12 patients with panic disorder who also had obstructive sleep apnea showed that they benefited from continuous positive airway pressure (CPAP) therapy, which decreased the panic attacks and reduced the use of alprazolam, suggesting an interaction of both diseases. 10 We therefore undertook this nationwide population-based study to elucidate the relationship of sleep apnea and subsequent panic disorder. 11 The data used in this study were retrieved from the Longitudinal Health Insurance Database 2000 (LHID2000), comprised of approximately 1,000,000 randomly sampl...

show abstract

“…In anxiety disorders, the literature is more limited. Nevertheless, volumetric reductions compared to healthy controls have been reliably identified in the amygdala, hippocampus, and the vmPFC in patients with post-traumatic stress disorder (PTSD) [46][47][48], panic disorder (PD) [49,50], generalized anxiety disorder (GAD), and phobias [51].…”

Section: Neural Network Involved In Affect Processingmentioning

confidence: 99%

Neuroscience-Informed Cognitive-Affective Training Interventions for Mood and Anxiety Disorders

Alvarez

Iacoviello

2015

Curr Treat Options Psych

View full text Add to dashboard Cite

Mood and anxiety disorders are characterized by abnormally persistent affective states. Neuroimaging studies have implicated the functioning of specific brain regions in the aberrant affective processing observed in mood and anxiety disorders: enhanced engagement of subcortical regions responsible for affect generation (amygdala, hippocampus) is coupled with reduced inhibitory cognitive control of affective processing from dorsolateral and ventrolateral prefrontal cortices. Emerging but compelling evidence suggests that neuroplastic mechanisms can be harnessed to remediate these abnormalities, thus offering the prospect of new therapeutic interventions. Cognitive-affective training is a particularly promising strategy for enhancing cognitive control over affective processes via modulation of these abnormally functioning neural networks. This paper presents a review of the current literature and a justification for developing cognitive-affective training, and proposes initial evidence for the efficacy of cognitive-affective training interventions. Cognitive-affective training interventions could represent a novel method for targeting perseverative thinking and negative affective biases in mood and anxiety disorders.

show abstract

Temporal and right frontal lobe alterations in panic disorder: a quantitative volumetric and voxel-based morphometric MRI study

Cited by 64 publications

References 42 publications

Individual differences in the Behavioral Inhibition System are associated with orbitofrontal cortex and precuneus gray matter volume

Individual differences in the Behavioral Inhibition System are associated with orbitofrontal cortex and precuneus gray matter volume

Sleep Apnea and Risk of Panic Disorder

Neuroscience-Informed Cognitive-Affective Training Interventions for Mood and Anxiety Disorders

Contact Info

Product

Resources

About