2017
DOI: 10.1186/s13014-017-0898-5
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Temporal and spatial dose distribution of radiation pneumonitis after concurrent radiochemotherapy in stage III non-small cell cancer patients

Abstract: Background and purposeRadiation pneumonitis (RP) is the most common subacute side effect after concurrent chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer. Several clinical and dose-volume (DV) parameters are associated with a distinct risk of symptomatic RP. The aim of this study was to assess the spatial dose distribution of the RP volume from first occurence to maximum volume expansion of RP.Material and methodsBetween 2007 and 2015, 732 patients with lung cancer were treated in an in… Show more

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Cited by 4 publications
(2 citation statements)
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“…Computational approaches have the advantages of allowing quantitative, continuous, objective and automated classification of radiological or functional lung damage. One of the most common approaches has been to use Hounsfield Unit (HU) density [ 31 , 32 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. Palma et al [ 52 ] performed deformable image registration on the phase of the planning scan with the lung volume most similar to the 3-month follow-up CT images of patients treated with SABR.…”
Section: Discussionmentioning
confidence: 99%
“…Computational approaches have the advantages of allowing quantitative, continuous, objective and automated classification of radiological or functional lung damage. One of the most common approaches has been to use Hounsfield Unit (HU) density [ 31 , 32 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. Palma et al [ 52 ] performed deformable image registration on the phase of the planning scan with the lung volume most similar to the 3-month follow-up CT images of patients treated with SABR.…”
Section: Discussionmentioning
confidence: 99%
“…This definition is not generally accepted as a risk factor for radiation pneumonitis because the low-dose area of the lung (V5) and intermediatedose area (V20) are related, and attempts to reduce the V5 may lead to an inability to reduce the V20 using modern radiotherapy techniques (7). There are few reports on the relationship between the area where radiation pneumonitis developed and the dose irradiated (29). As these previous studies did not use the deformable registration of diagnostic CT, the collation accuracy between the isodose line or irradiation field and the area where pneumonitis developed is expected to be inferior.…”
Section: Discussionmentioning
confidence: 99%