Temporal and spatial regulation of expression of heparin-binding epidermal growth factor-like growth factor in the human endometrium: A possible role in blastocyst implantation

Yoo, Hyung-Jin; Barlow, David H.; Mardon, Helen J.

doi:10.1002/(sici)1520-6408(1997)21:1<102::aid-dvg12>3.0.co;2-c

Cited by 155 publications

(68 citation statements)

References 42 publications

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“…HBEGF is most abundant in luminal epithelial cells during implantation in rodent and human pregnancy (33,52). An interesting difference is that in the mouse HBEGF is also expressed in the trophoblast; we did not find any staining in the opossum trophoblast.…”

Section: Discussionmentioning

confidence: 99%

Embryo implantation evolved from an ancestral inflammatory attachment reaction

Griffith

Chavan

Protopapas

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

200

162

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The molecular changes that support implantation in eutherian mammals are necessary to establish pregnancy. In marsupials, pregnancy is relatively short, and although a placenta does form, it is present for only a few days before parturition. However, morphological changes in the uterus of marsupials at term mimic those that occur during implantation in humans and mice. We investigated the molecular similarity between term pregnancy in the marsupials and implantation in eutherian mammals using the gray short-tailed opossum (Monodelphis domestica) as a model. Transcriptomic analysis shows that term pregnancy in the opossum is characterized by an inflammatory response consistent with implantation in humans and mice. This immune response is temporally correlated with the loss of the eggshell, and we used immunohistochemistry to report that this reaction occurs at the materno-fetal interface. We demonstrate that key markers of implantation, including Heparin binding EGF-like growth factor and Mucin 1, exhibit expression and localization profiles consistent with the pattern observed during implantation in eutherian mammals. Finally, we show that there are transcriptome-wide similarities between the opossum attachment reaction and implantation in rabbits and humans. Our data suggest that the implantation reaction that occurs in eutherians is derived from an attachment reaction in the ancestral therian mammal which, in the opossum, leads directly to parturition. Finally, we argue that the ability to shift from an inflammatory attachment reaction to a noninflammatory period of pregnancy was a key innovation in eutherian mammals that allowed an extended period of intimate placentation.placenta | marsupial | inflammation | pregnancy | evolution I n eutherian (so-called "placental") mammals, pregnancy begins when the blastocyst attaches to the uterine wall, followed by the establishment of a stable fetal-maternal interface. Implantation involves the apposition, attachment, and, in many species, the invasion of the blastocyst into the uterus (1). In particular, structural and molecular changes occur in the luminal epithelia that allow the embryo to attach and invade the uterus (2). Epithelial changes are followed by remodeling of the endometrial stroma, generally known as "decidualization," i.e., the transformation of endometrial stromal fibroblasts into decidual stromal cells, as well as modifications of the endometrial vascular bed (3). When these changes do not occur or occur incompletely, blastocysts fail to implant, resulting in early pregnancy failure (4, 5). In humans, 75% of unsuccessful pregnancies are the result of failures of implantation, and implantation failure is the limiting factor for in vitro fertilization treatment. Furthermore, decades of research have failed to produce clinically effective treatments that increase uterine receptivity to implantation (6-8). Given the magnitude of this problem, extensive efforts have been made to characterize the endometrium for signatures of receptivity (9, 10).Implantati...

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Section: Discussionmentioning

confidence: 99%

Embryo implantation evolved from an ancestral inflammatory attachment reaction

Griffith

Chavan

Protopapas

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

200

162

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“…Significant research has been done to directly assess uterine receptivity, including histologic dating, immuno-histochemical methods for measurement of endometrial sex steroid receptor concentrations, scanning electron microscopy assessing pinopod expression, and more recently, the role of cytokines, growth factors, and integrin molecules have been studied [20][21][22][23][24]. These methods are obviously not practical in actual ET cycles.…”

Section: Discussionmentioning

confidence: 99%

Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles

Barker

Boehnlein

Kovács

et al. 2009

J Assist Reprod Genet

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Purpose To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes. Methods Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist downregulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer.Results Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes. Conclusions Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes.

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“…Showing conservation with the mouse, HB-EGF peaks at the window of implantation (Yoo et al 1997) and ErbB4 is expressed in the trophectoderm in periimplantation human blastocysts (Chobotova et al 2002). In addition, correlative links between elevated expression of Ar and TGF-a with endometrial cancers have been made (Pfeiffer et al 1997).…”

Section: Growth Factorsmentioning

confidence: 99%

Animal models of implantation

Lee

DeMayo²

2004

Reproduction

240

155

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Implantation is an intricately timed event necessary in the process of viviparous birth that allows mammals to nourish and protect their young during early development. Human implantation begins when the blastocyst both assumes a fixed position in the uterus and establishes a more intimate relationship with the endometrium. Due to the impracticalities of studying implantation in humans, animal models are necessary to decipher the molecular and mechanical events of this process. This review will discuss the differences in implantation between different animal models and describe how these differences can be utilized to investigate discrete implantation stages. In addition, factors that have been shown to be involved in implantation in the human and other various animal models including growth factors, cytokines, modulators of cell adhesion, and developmental factors will be discussed, and examples from each will be given.

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Temporal and spatial regulation of expression of heparin-binding epidermal growth factor-like growth factor in the human endometrium: A possible role in blastocyst implantation

Cited by 155 publications

References 42 publications

Embryo implantation evolved from an ancestral inflammatory attachment reaction

Embryo implantation evolved from an ancestral inflammatory attachment reaction

Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles

Animal models of implantation

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