Temporal arteritis and polymyalgia rheumatica in north-eastern Spain: clinical spectrum and relationship over a 15 year period

Narváez, Javier; Nolla-Solé, J M; Clavaguera, Teresa; Valverde-García, J; Roig-Escofet, D

doi:10.1016/s1297-319x(02)00007-6

Cited by 8 publications

(2 citation statements)

References 35 publications

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“…Hepatic involvement in polymyalgia rheumatica is a recognized but uncommon association. Serum alkaline phosphatase appears to be the most consistently elevated enzyme in 18 to 62% of patients with polymyalgia rheumatic 4,5 . Elevated alanine and aspartate transaminases occur in 18% of patients with polymyalgia rheumatica 5 .…”

Section: Discussionmentioning

confidence: 97%

Abnormal Liver Function Test in a Patient with Polymyalgia Rheumatica

Khoo

Boo

et al. 2014

Proceedings of Singapore Healthcare

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Polymyalgia rheumatica is characterised by pain and stiffness of neck muscles, shoulder and pelvic girdles that is worse in the morning, generally accompanied by constitutional symptoms and an elevated erythrocyte sedimentation rate. Abnormal liver function is uncommonly associated with polymyalgia rheumatica. We describe a case of an elderly lady with polymyalgia rheumatica who presented with a history of early morning stiffness and pain in the lower limbs and markedly deranged liver function. She responded remarkably well to corticosteroid therapy with rapid improvement in her symptoms and normalisation of her liver function test.

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Section: Discussionmentioning

confidence: 97%

Abnormal Liver Function Test in a Patient with Polymyalgia Rheumatica

Khoo

Boo

et al. 2014

Proceedings of Singapore Healthcare

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“…Apart from their frequent cooccurrence, PET evidence suggests that limited large vessel vasculitis may occur in patients with isolated PMR [20], and histologically normal temporal artery biopsies have shown similarities in cytokine profile between GCA and isolated PMR [21]. A minority of patients with isolated PMR subsequently develops GCA, which may occur years later and despite glucocorticoid therapy [22,23]. Patients diagnosed with GCA at a younger age appear to have a more severe clinical course, with a phenotype that includes predominantly large vessel involvement, a higher risk of aortic complications and more frequent need for intensification of immunosuppression, as compared to older patients who more often develop cranial disease [9].…”

Section: Discussionmentioning

confidence: 99%

Impact of age at diagnosis in polymyalgia rheumatica: A retrospective cohort study of 218 patients

Hemelen

Betrains

Vanderschueren

et al. 2020

Autoimmunity Reviews

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Background: Polymyalgia rheumatica (PMR) is a common musculoskeletal inflammatory disease that may occur with giant-cell arteritis (GCA) or in an isolated form. While the incidence is highest in the elderly, there is a paucity of data on its presentation, clinical course and response to treatment in younger individuals. Methods: We conducted a retrospective review of 40 patients who were diagnosed with isolated PMR under the age of 60 and 178 patients diagnosed above this age, taking into account clinical and laboratory data and treatment history. Results: Patients who were diagnosed at a younger age had lower acute-phase reactant levels at diagnosis but not after initiation of treatment or at the time of relapse. The risk of relapse was lower in the group diagnosed under age 60 (35% vs 55%). Cumulative and maximal glucocorticoid doses, use of glucocorticoid-sparing agents and duration of glucocorticoid treatment, did not differ between the groups. In multivariate analysis, younger age at diagnosis was associated with cervical pain and male gender. Conclusion: Compared to patients diagnosed above age 60, patients diagnosed with PMR at a younger age have a lower risk of relapse, but similar long-term outcomes with regards to continued need for treatment.

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