“…Temporal artery biopsy is considered the gold standard for the diagnosis of GCA, [ 162 ] with pathognomonic features of transmural active inflammation with or without giant cells involving the media [ 163 , 164 ]. However, a more limited inflammation, restricted to the adventitial and/or periadventitial tissue, has been observed in a group of patients with GCA/PMR [ 165 , 166 ], though the clinical significance of this finding remains controversial [ 167 – 169 ]. Recently, a retrospective cohort study was performed to evaluate the characteristics and significance of inflammation limited to the adventitial and/or periadventitial tissue of temporal arteries.…”