Temporal aspects of anticholinergic- and anticholinesterase-induced amnesia for an appetitive habit.

The Cholinergic Model of Dementia, Alzheimer Type: Progression from the Unitary Transmitter Concept

“…Deutsch [12. 27], Deutsch and Liebowitz [14] and Wiener and Deutsch [16] conducted a scries of studies with physostigmine and DFP. The effects on recall de pended on time of drug administration: no effect if given up to 3 days after training, impairment after 7 days, and facilitation after 21 days.…”

“…Dcutsch [12] added experiments in which anticholinergic drugs were administered after training of a task. Not only was recall impaired, but the effect was influenced by time [13][14][15][16] and reversed by the anticholinesterases, physostigminc and di-isopropylfiuorophosphate (DTP: fig. 2).…”

The Hippocampus as a Cognitive Map

“…Though much of this stimulation work is intriguing, it is plain that Deutsch, Hamburg, and Dahl 1966, Deutsch and Leibowitz 1966, Wiener and Deutsch 1968 have reported that various changes in retention are a function of changes in cholinergic systems, which can be manipulated by anti-cholinergic and anti-cholinesterase drugs injected into the hippocampus. In a recent study George and Mellanby (1974) have shown that the carrier used in such studies (peanut oil) can, by itself, affect memory.…”

Drugs as Research Tools in Psychology: Cholinergic Drugs and Information Processing

“…However, as forgetting involves decreases in transmitter at these cholinergic synapses, then these effects would be reversed at even longer reten tion intervals. , Deutsch and Liebowitz [1966], Hamburg [1967], and Wiener and Deutsch [1968] tested the hypothesis by using a simple Y maze escape task.…”

“…Information retrieval will then be impaired. , Deutsch and Liebowitz [1966], Hamburg [1967], and Wiener and Deutsch [1968] trained rats in a Y maze to escape foot shocks and to get food. The rats were trained to a criterion of ten correct choices in succession.…”