Exploiting natural sun and wind resources in remote and isolated areas is undoubtedly an excellent decision to generate electrical energy due to their availability and cleanliness. Various systems were used to generate this energy, such as photovoltaics (PV), wind turbine sand other energy systems. Moreover, for optimum energy use, some of these systems are combined either with each other or with other conventional systems, such as diesel generators with PV systems (i.e., hybrid systems). This work aims to present a technical-economic study of PV/diesel autonomous hybrid systems to supply electrical power for an isolated house located in a hot desert climate, Adrar. For optimizing the hybrid systems, hourly input data of solar radiation and load were used according to two configurations, where the annual load is 11.2 kWh/day. The findings showed that the diesel system had a high cost, with a cost for energy of $0.407/kWh and a fuel price of $0.140/l. Among the hybrid power systems but with significant pollution, the proposed hybrid system 2 kw photovoltaic and diesel generator with 2.3 kW has important economic feasibility, where the energy cost amounted to $0.172/kWh. In addition, CO2 emissions are reduced by approximately 5 tons every year compared to an independent diesel generator system.