Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study

Abstract

BackgroundAlthough the association of the measles, mumps, and rubella vaccine with autism spectrum disorder has been convincingly disproven, the onset of certain brain-related autoimmune and inflammatory disorders has been found to be temporally associated with the antecedent administration of various vaccines. This study examines whether antecedent vaccinations are associated with increased incidence of obsessive–compulsive disorder (OCD), anorexia nervosa (AN), anxiety disorder, chronic tic disorder, attention deficit hyperactivity disorder, major depressive disorder, and bipolar disorder in a national sample of privately insured children.MethodsUsing claims data, we compared the prior year’s occurrence of vaccinations in children and adolescents aged 6–15 years with the above neuropsychiatric disorders that were newly diagnosed between January 2002 and December 2007, as well as two control conditions, broken bones and open wounds. Subjects were matched with controls according to age, gender, geographical area, and seasonality. Conditional logistic regression models were used to determine the association of prior vaccinations with each condition.ResultsSubjects with newly diagnosed AN were more likely than controls to have had any vaccination in the previous 3 months [hazard ratio (HR) 1.80, 95% confidence interval 1.21–2.68]. Influenza vaccinations during the prior 3, 6, and 12 months were also associated with incident diagnoses of AN, OCD, and an anxiety disorder. Several other associations were also significant with HRs greater than 1.40 (hepatitis A with OCD and AN; hepatitis B with AN; and meningitis with AN and chronic tic disorder).ConclusionThis pilot epidemiologic analysis implies that the onset of some neuropsychiatric disorders may be temporally related to prior vaccinations in a subset of individuals. These findings warrant further investigation, but do not prove a causal role of antecedent infections or vaccinations in the pathoetiology of these conditions. Given the modest magnitude of these findings in contrast to the clear public health benefits of the timely administration of vaccines in preventing mortality and morbidity in childhood infectious diseases, we encourage families to maintain vaccination schedules according to CDC guidelines.

Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

“…Under incomplete mitochondrial development and hypoxic conditions of placenta, organogenesis and angiogenesis of embryo‐fetus require proper architectural organization and functioning of trophoblast epithelium for providing and consuming appropriate and sufficient growth factors/hormones, nutrients, enzymes, trace elements (metals) and respective constituent or induced receptor molecules. Exposure of the embryo‐fetus to flu shot and incipient, could pose serious threats to survival and health of both mother and fetus including altered nutrients in organogenesis, transition of myoblasts to myotube development, ratios of constituent/induced receptors, as potential contributors in growth retardation or growth promotion, fetus abortion or impaired health of newborn, infant, toddler, that also influence immunity during adulthood and aging process 1,5,8,20,24,27‐85,87‐125,129,192 (manuscript in preparation)] (Figures 1, 3 and 4).…”

“…As shown below, pathogen‐specific vaccines (eg, polio, swine flu, hepatitis a, b, c, MMRs, meningitis, shingles, anthrax, pertussis, HPV, SARS, Ebola, Zika, or ‘covid‐19’) and incipient weaken/destroy the complex electrobiology of immunity and Not Promote It ! 1,5,8,11,17,20,27–178 …”

Multiple Vaccinations and the Enigma of Vaccine Injury

“…Those with newly diagnosed AN were more likely than matched controls to have had any vaccination in the previous 3 months (hazard ratio (HR): 1.80; 95% CI: 1.21–2.68), and those with AN, OCD, and anxiety disorder were more likely than controls to have received influenza vaccinations during the previous 3, 6, and 12 months. HRs >1.40 were also found for hepatitis A vaccination with OCD and AN, for hepatitis B with AN, and meningitis with AN and chronic tic disorder [ 54 ]. Other research has found that the therapeutic use of 13-cis-RA (isotretinoin) is associated with the onset of depression, psychosis, and suicide [ 55 ], and both depression and cognitive disturbances in 1% to 11% of patients with acne [ 56 ].…”

A Pediatric Neurology Perspective on Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection and Pediatric Acute-Onset Neuropsychiatric Syndrome

“…The authors concluded that the low absolute risk and high public health benefit favored continued adherence to recommended vaccination schedules. 25 As in the PANDAS claims-data studies, there is no distinction between, or knowledge of, a severe dramatic onset vs a gradual onset. The magnitudes of the hazard ratios-the strength of the association, were usually close to 1.…”