Temporal associations of plasma levels of the secreted phospholipase A2 family and mortality in severe COVID‐19
Eric Lu,
Aki Hara,
Shudong Sun
et al.
Abstract:Previous research suggests that group IIA‐secreted phospholipase A2 (sPLA2‐IIA) plays a role in and predicts lethal COVID‐19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal relationship between levels of several members of a family of sPLA2 isoforms and the severity of COVID‐19 in 214 ICU patients. The levels of six secreted PLA2 isoforms, sPLA2‐IIA, sPLA2‐V, sPLA2‐X, sPLA2‐IB, sPLA2‐IIC, and sPLA2‐XVI, increased over the first 7 ICU days in those who succumbed… Show more
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