Temporal boundary of the sensitive period for hormonal organization of social play in juvenile rats

Beatty, William W.; Dodge, Anthony M.; Traylor, Kathy L.; Meaney, Michael J.

doi:10.1016/0031-9384(81)90017-2

Cited by 72 publications

(42 citation statements)

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“…Absence of a castration effect on social play in prepubertal males has also been reported by Beatty et al (1981), who found no effect on juvenile social play of castration at 10 or more days of age. Meaney and Stewart (1981b) have also reported no difference in the social play of 23-day-old castrates when compared with intact males at 31-40 days of age.…”

Section: Discussionmentioning

confidence: 69%

“…have also determined that the administration of exogenous testosterone to juvenile males does not affect the frequency of play initiation or play fighting. Conversely, neonatal exposure to testosterone has repeatedly been shown to increase juvenile social play (Beatty, Dodge, Traylor, & Meaney, 1981;Meaney & Stewart, 1981b;Meaney, Stewart, Poulin, & McEwen, 1983;Olioff & Stewart, 1978).…”

mentioning

confidence: 99%

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Play soliciting behavior in prepubertal and postpubertal male rats

Thor¹,

Holloway²

1985

Animal Learning & Behavior

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Pre-and postpubertal play soliciting behavior was observed in intact males, castrate males, sham-operated males, and female controls. Although play soliciting decreased markedly with age in all groups, male treatment groups did not differ reliably on pre-or postpubertal tests. Males, however, engaged in reliably greater play soliciting than females on all measures in both preand postpubertal tests. These results suggest that the major decrease in social play associated with the attainment of sexual maturity is apparent in the play soliciting behavior of both sexes and may be attributed to maturation effects other than that associated with gonadal hormones. The results are discussed in reference to organizational and activational effects of male gonadal hormones on measures of social play behavior.

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Section: Discussionmentioning

confidence: 69%

mentioning

confidence: 99%

Play soliciting behavior in prepubertal and postpubertal male rats

Thor¹,

Holloway²

1985

Animal Learning & Behavior

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“…Although significant increases in plasma testosterone levels coincide with the transition from play fighting to adult aggression in male golden hamsters, preweaning castration does not affect this behavioral shift [Vomachka and Greenwald, 1979;Pellis and Pellis, 1988;Romeo et al, 2003;. Similarly, preweaning gonadectomy in rats does not affect playful defenses outside the dominant/subordinate hierarchy, as castrated and intact juvenile rats show similar levels of play-fighting frequency and are just as likely to perform full rotations [Beatty et al, 1981;Smith et al, 1996;Pellis, 2002]. The lack of a clear relationship between pubertal increases in testosterone and the development of agonistic behavior might be similar to castration studies in adults, in which differences can be a result of experimental procedures.…”

Section: Gonadal Steroids and The Development Of Offensive Responsesmentioning

confidence: 93%

Stress, Aggression, and Puberty: Neuroendocrine Correlates of the Development of Agonistic Behavior in Golden Hamsters

Wommack

Delville²

2007

Brain Behav Evol

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During puberty, agonistic behaviors undergo significant transitions. In golden hamsters, puberty is marked by a transition from play fighting to adult aggression. During early puberty, male golden hamsters perform play-fighting attacks. This response type is gradually replaced by adult attacks over the course of puberty. Interestingly, this behavioral transition does not appear to be controlled by changes in gonadal steroids. Instead, the shift from play fighting to adult aggression in male golden hamsters is driven by pubertal changes in glucocorticoid levels. Specifically, the transition from play fighting to adult aggression coincides with developmental increases in glucocorticoid levels, and external manipulations such as social stress or treatment with corticosteroid receptor agonists accelerate this behavioral shift. Moreover, the consequences of social stress differ greatly between juvenile and adult male golden hamsters. Although a single defeat during adulthood causes severe and long lasting behavioral and neuroendocrine consequences, socially subjugated juveniles show only transient behavioral effects. As such, it is likely that pubertal changes in the HPA axis are not only linked to the maturation of offensive responses but also determine the consequences of social stress. Combined, these studies in golden hamsters provide a novel mechanism for the development of agonistic behavior and suggest that age related differences in behavioral plasticity are mediated by the development of the HPA axis.

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“…In rats, play fighting, also called rough-and-tumble play, peaks between postnatal days 30-40 (Thor and Holloway, 1984), and occurs more frequently in males than females (Olioff and Stewart, 1978;Pellis and Pellis, 1990). Play fighting is decreased in male rats castrated at birth and its frequency begins to decline at the onset of puberty (Beatty et al, 1981;Meaney, 1988;Pellis and Pellis, 1990). Analysis of Tfm male rats suggests that ARs are involved in the development of play fighting behavior since, as juveniles, Tfm males show decreased play fighting behavior compared to wt males (Meaney et al, 1983;Meaney, 1988), although recent data suggest that this difference may depend on the testing paradigm (Field et al, 2006).…”

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confidence: 99%

The role of androgen receptors in the masculinization of brain and behavior: What we've learned from the testicular feminization mutation

Zuloaga

Puts

Jordan

et al. 2008

Hormones and Behavior

213

156

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Many studies demonstrate that exposure to testicular steroids such as testosterone early in life masculinizes the developing brain, leading to permanent changes in behavior. Traditionally, masculinization of the rodent brain is believed to depend on estrogen receptors (ERs) and not androgen receptors (ARs). According to the aromatization hypothesis, circulating testosterone from the testes is converted locally in the brain by aromatase to estrogens, which then activate ERs to masculinize the brain. However, an emerging body of evidence indicates that the aromatization hypothesis cannot fully account for sex differences in brain morphology and behavior, and that androgens acting on ARs also play a role. The testicular feminization mutation (Tfm) in rodents, which produces a nonfunctional AR protein, provides an excellent model to probe the role of ARs in the development of brain and behavior. Tfm rodent models indicate that ARs are normally involved in the masculinization of many sexually dimorphic brain regions and a variety of behaviors, including sexual behaviors, stress response and cognitive processing. We review the role of ARs in the development of the brain and behavior, with an emphasis on what has been learned from Tfm rodents as well as from related mutations in humans causing complete androgen insensitivity. Keywordscomplete androgen insensitivity syndrome -CAIS; vasopressin; anxiety; spatial memory; bed nucleus; medial amygdala; SDN-POA; sexual behavior; aggression; VMH Exposure to testicular steroids such as testosterone (T) early in life masculinizes the developing brain, leading to permanent changes in behavior in a wide variety of animal models (Morris et al., 2004). According to the aromatization hypothesis, T is converted by aromatase into 17-β estradiol (E2), which then acts on estrogen receptors (ERs) to masculinize the brain (Naftolin et al., 1975). Traditionally, aromatization is believed to be the mechanism by which the rodent brain becomes masculinized and defeminized. Some sexually dimorphic regions within the hypothalamus adhere well to this hypothesis, including the sexually dimorphic nucleus of the preoptic area (SDN-POA) and anteroventral periventricular nucleus (AVPV). T spares neuronsCorresponding author: Damian Zuloaga, Neuroscience Program, 108 Giltner Hall, Michigan State University, East Lansing, MI 48824, Phone: Fax: (517) 432-2744, Email: E-mail: zuloagad@msu.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript from death in the SDN-POA...

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Temporal boundary of the sensitive period for hormonal organization of social play in juvenile rats

Cited by 72 publications

References 14 publications

Play soliciting behavior in prepubertal and postpubertal male rats

Play soliciting behavior in prepubertal and postpubertal male rats

Stress, Aggression, and Puberty: Neuroendocrine Correlates of the Development of Agonistic Behavior in Golden Hamsters

The role of androgen receptors in the masculinization of brain and behavior: What we've learned from the testicular feminization mutation

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