[Purpose] The purpose of this study was to investigate the relationship between psychological health and college life anxiety among 44 female students in the first academic year of physical therapy.[Subjects] Fourtyfour female freshmen with an average age of 18.9 years. [Methods] Their psychological health was assessed using the Cornell Medical Index-Health Questionnaire (CMI), and campus life anxiety was assessed using the College Life Anxiety Scale (CLAS).[Results] Thirty-two percent of students were diagnosed with neurosis or its possibility, and these students had significantly higher rates of anxiety about daily life, assessment, and maladjustment to college than normal students.[Conclusion] Students with neurosis or its possibility tend to have feelings of anxiety about relationships with friends and teachers, scholastic results, maladjustment to college, and future employment. Therefore, they should be checked at the time of the entrance examination for their psychological health condition, and after entrance, supported to decrease their anxieties in order to facilitate good relationships with others, as early as possible, and to encourage a sense of profession in association with specialists of psychology.