Temporal Characteristics of Response Integration Evoked by Multiple Whisker Stimulations in the Barrel Cortex of Rats

Shimegi, Satoshi; Ichikawa, Takehiko; Akasaki, Takafumi; Sato, Hiromichi

doi:10.1523/jneurosci.19-22-10164.1999

Cited by 96 publications

(116 citation statements)

References 39 publications

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“…Additionally, unit recording (ArmstrongJames and Fox 1987;Simons 1978) and optical imaging (Kleinfeld and Delaney 1996) studies have reported activity patterns in the barrel cortex following single-whisker deflections elongated along rows. In line with those results, electrophysiological investigations have mainly tested multi-whisker integration along rows (Carvell and Simons 1988;Shimegi et al 1999Shimegi et al , 2000Simons 1985;Simons and Carvell 1989; but see also Mirabella et al 2001). However, a supralinear interaction most prominent for whiskers located in the same arc was recently described (Ghazanfar and Nicolelis 1997), suggesting that modulatory influences could exist both in the rostrocaudal and dorsoventral directions.…”

Section: Introductionmentioning

confidence: 70%

“…First, we calculated the facilitation index (FI) proposed by Shimegi et al (1999Shimegi et al ( , 2000. The FI is the ratio between the observed response to the combined deflection of whiskers and the sum of responses to individual deflections calculated on the same time window.…”

Section: Discussionmentioning

confidence: 99%

“…These investigations have mostly reported a suppressive effect of the stimulation of one whisker on the response to stimulation of another whisker, using both electrophysiological recordings (Brumberg et al 1996;Carvell and Simons 1988;Mirabella et al 2001;Simons 1985;Simons and Carvell 1989) and optical imaging techniques (Goldreich et al 1998;Kleinfeld and Delaney 1996). However, a facilitatory interaction has also been described by several laboratories (Erchova et al 2003;Ghazanfar and Nicolelis 1997;Ghazanfar et al 2000;Shimegi et al 1999Shimegi et al , 2000. These apparently conflicting results could arise from several differences in the experimental protocols used, namely the range of interstimulus intervals (ISIs), the laminar location of the recordings, and the type of recorded neurons.…”

Section: Introductionmentioning

confidence: 99%

“…However, a supralinear interaction most prominent for whiskers located in the same arc was recently described (Ghazanfar and Nicolelis 1997), suggesting that modulatory influences could exist both in the rostrocaudal and dorsoventral directions. Because the effect of the deflection of one whisker on the response to the deflection of another whisker depends on the precise ISI (Shimegi et al 1999(Shimegi et al , 2000, it becomes critical to test multi-whisker integration both along rows and arcs with a range of ISIs.…”

Section: Introductionmentioning

confidence: 99%

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Spatiotemporal Characteristics of Neuronal Sensory Integration in the Barrel Cortex of the Rat

Ego-Stengel¹,

Souza²,

Jacob³

et al. 2005

Journal of Neurophysiology

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. Spatiotemporal characteristics of neuronal sensory integration in the barrel cortex of the rat. J Neurophysiol 93: 1450 -1467, 2005. First published October 20, 2004 doi:10.1152/ jn.00912.2004. In primary sensory cortices, neuronal responses to a stimulus presented as part of a rapid sequence often differ from responses to an isolated stimulus. It has been reported that sequential stimulation of two whiskers produces facilitatory modulations of barrel cortex neuronal responses. These results are at odds with the well-known suppressive interaction that has been usually described. Herein, we have examined the dependency of response modulation on the spatiotemporal pattern of stimulation by varying the spatial arrangement of the deflected vibrissae, the temporal frequency of stimulation, and the time interval between whisker deflections. Extracellular recordings were made from primary somatosensory cortex of anesthetized rats. Two contralateral whiskers were stimulated at 0.5 and 8 Hz at intervals ranging from 0 to Ϯ30 ms. Response interactions were assessed during stimulation of the principal and adjacent whiskers, first from the same row and second from the same arc. When tested at 0.5 Hz, 59% of single units showed a statistically significant suppressive interaction, whereas response facilitation was found in only 6% of cells. In contrast, at 8 Hz, a significant supralinear summation was observed in 19% of the cells, particularly for stimulations along an arc rather than along a row. Multi-unit recordings showed similar results. These observations indicate that most of the interactions in the barrel cortex during two-whisker stimulation are suppressive. However, facilitation can be revealed when stimuli are applied at a physiological frequency and could be the basis for internal representations of the spatiotemporal pattern of the stimulus.

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Section: Introductionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spatiotemporal Characteristics of Neuronal Sensory Integration in the Barrel Cortex of the Rat

Ego-Stengel¹,

Souza²,

Jacob³

et al. 2005

Journal of Neurophysiology

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“…The majority of authors try to support a compulsory convention of waves classification in frequency ranges, which took the attention of Jus et al (1954), Creutzfeldt et al (1966), Eckhorn (1993), Shimegi (1999), and also Wypych et al (2004). However, Saito et al (2005) give the ranges of rhythms of cortical origin according the follow ing criteria: alpha waves (α) in a range (8-12,9) Hz, beta (β) in a range (14,1-25}Hz, theta (θ) in a range (4-7,9) Hz, and delta (δ) in a range (1-3,9) Hz.…”

Section: Determination Of a Normal Reaction Of The Cerebral Cortex Bimentioning

confidence: 99%

Recording of bioelectrical activity changes in sheep cerebral cortex

Cwynar

Zawadzki

2010

Arch. med. vet.

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RESUMENEl objetivo de este estudio es presentar el uso práctico de la electroencefalografía (EEG), demostrando el aspecto básico de EEG en ovejas, así como su utilidad en el análisis de las alteraciones provenientes del sistema nervioso central. Se examinaron 10 hembras híbridas de Oveja Merino Polaca, seleccionadas especialmente con fines experimentales. Debido a la falta de una fórmula unificada en el método de EEG en animales, se realizó un registro de potenciales provenientes de algunos puntos escogidos tras el experimento en cabezas de animales. Durante los experimentos realizados se demostró que la corteza cerebral de ovejas se caracteriza por una dinámica muy alta, hecho que fue demostrado al examinar las reacciones del sistema nervioso central a los factores tales como: el hambre, la estimulación auditiva o la inyección de xylazyna. La corteza cerebral de ovejas en el estado de reposo muestra una actividad bioeléctrica de una amplitud media de 30 μV y una frecuencia de 25 Hz, con lo cual se confirma la existencia del ritmo beta [β]. La aplicación de un estímulo acústico permite estimular el sistema nervioso central de oveja, lo que queda comprobado por una elevación de la amplitud media (por 23%) y de la frecuencia (por 21%) de la actividad bioeléctrica de la corteza cerebral, como también lo confirma el electroencefalograma conseguido. Los datos obtenidos demuestran que la zona que se caracteriza por tener el tiempo más corto de reacción es la zona del mesencéfalo, con un tiempo medio de reacción de 0,56 segundos (± 0,005 s). Se discute además la aplicabilidad de los experimentos, así como también la posibilidad de unificar el método de EEG.

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Neonatal capsaicin treatment modulates experience‐dependent plasticity in the rat barrel cortex

Sheibani

Shamsizadeh

Afarinesh

et al. 2010

J of Comparative Neurology

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Previous studies have reported that capsaicin-induced C-fiber depletion results in expansion of low threshold somatosensory mechanoreceptive fields. Here we used this paradigm to investigate its effect on experience-dependent plasticity in the barrel cortex of rats. All but the D2 vibrissa were first plucked on postnatal day 0 (P0), P5, or P8, and kept plucked for a period of 30 days before being allowed to regrow for 7-9 days prior to the recording session. To assess receptive field characteristics the spared D2 principal whisker (PW) and the deprived D1 adjacent whisker (AW) were moved either singly or in concert, neuronal responses being recorded in layers IV and V of the D2 barrel. In vehicle-treated rats, PW-evoked ON responses (layer IV) were increased only in those animals that first had their vibrissae plucked on P0, whereas AW-evoked ON responses (layers IV and V) were decreased in the P0, P5, and P8 groups. In the capsaicin-treated animals, PW-evoked ON responses (layer IV) were increased in all three groups, but no decrease was recorded in the AW-evoked ON (layers IV and V) responses. In the vehicle- and capsaicin-treated animals, the greatest decrease in inhibitory interactions was observed in the P5 and P0 groups, respectively. These findings indicate that, following the induction of experience-dependent plasticity, the resultant changes in excitatory and integrative circuits can be further influenced by C-fiber depletion.

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Temporal Characteristics of Response Integration Evoked by Multiple Whisker Stimulations in the Barrel Cortex of Rats

Cited by 96 publications

References 39 publications

Spatiotemporal Characteristics of Neuronal Sensory Integration in the Barrel Cortex of the Rat

Spatiotemporal Characteristics of Neuronal Sensory Integration in the Barrel Cortex of the Rat

Recording of bioelectrical activity changes in sheep cerebral cortex

Neonatal capsaicin treatment modulates experience‐dependent plasticity in the rat barrel cortex

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