Temporal characterization of perfluorinated ion exchange coated microvoltammetric electrodes for in vivo use

Kristensen, Eric W.; Kuhr, Werner G.; Wightman, R. Mark

doi:10.1021/ac00141a003

Cited by 259 publications

(125 citation statements)

References 40 publications

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“…15,60 If an ion exchanger characterized by proper selectivity is used, it is possible to determine trace levels of ionic electroactive analytes (metals, pharmaceutical compounds, biological compounds) at submicromolar concentration levels. [60][61][62][63][64][65][66][67][68][69][70][71][72][73] The most popular cation exchanging system is Nafion  , although poly(styrene sulphonate), poly(vinyl sulphate), deprotonated poly(acrylic acid) and poly(-L-lysine), Tosflex, poly(vinylpyridine) and cellulose acetate have received significant attention. [73][74][75][76][77][78][79][80][81][82][83][84][85][86] In addition, the preconcentrating agent also may acts as a permeselective coating, offering selectivity by exclusion from the surface of unwanted matrix constituents, while allowing transport of the target analyte.…”

Section: Chemically Modified Electrodesmentioning

confidence: 99%

Electrochemical sensors: a powerful tool in analytical chemistry

Stradiotto¹,

Yamanaka²,

Zanoni³

2003

J. Braz. Chem. Soc.

335

154

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Sensores potenciométricos, amperométricos e condutométricos são sensores eletroquímicos com imensa aplicação nas áreas de meio ambiente, indústria e análises clínicas. O presente trabalho apresenta uma revisão generalizada dos aspectos fundamentais, os desenvolvimento e a contribuição destes sensores na área de química analítica, e reporta alguns aspectos relevantes dos avanços na área de sensores eletroquímicos no Brasil.Potentiometric, amperometric and conductometric electrochemical sensors have found a number of interesting applications in the areas of environmental, industrial, and clinical analyses. This review presents a general overview of the three main types of electrochemical sensors, describing fundamental aspects, developments and their contribution to the area of analytical chemistry, relating relevant aspects of the development of electrochemical sensors in Brazil.

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Section: Chemically Modified Electrodesmentioning

confidence: 99%

Electrochemical sensors: a powerful tool in analytical chemistry

Stradiotto¹,

Yamanaka²,

Zanoni³

2003

J. Braz. Chem. Soc.

335

154

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“…For example, the use of Nafion as an external membrane for electrochemical NO sensors [10,14,16,17] could exacerbate interference from cationic electroactive species common to the biological milieu such as the neurotransmitters, dopamine (DA), norepinephrine (NE), and 5-hydroxytryptamine (5-HT), all positively charged at physiological pH. As a matter of fact, the cation-exchange properties of Nafion have been exploited to enhance detection of cationic neurotransmitters [18][19][20]. Selectivity of NO detection has been achieved using several of the previously reported NO electrodes through the use of scanning or differential measurement techniques, e.g., differential pulse voltammetry (DPV) [9,12,21].…”

Section: Introductionmentioning

confidence: 99%

Multimembrane Carbon Fiber Electrodes for Physiological Measurements of Nitric Oxide

Mitchell

Michaelis²

1998

Electroanalysis

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Carbon fiber electrodes were chemically modified with polymeric membranes of nickel porphyrin, Nafion, immobilized ascorbic acid oxidase and either polylysine or polypyridinium to provide selectivity of anodic detection of nitric oxide (NO) in physiological systems. These composite electrodes were demonstrated to preclude interference by physiological concentrations of electroactive species and by L-arginine (L-Arg), N-nitro-L-arginine methyl ester (L-NAME) and carbon monoxide (CO). The composite electrode response time was 500 ms and the chronocoulometric detection limit was 0.5 nM NO. In situ measurement of NO was demonstrated in brain slices in vitro and in the anesthetized brain in vivo with detection limits of 8 and 173 nM NO in these tissue preparations, respectively.

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“…The time course of the measurement is represented in the Y-Z plane of the 3-D plot (see Fig. 4), and the response time can be evaluated by monitoring the appearance of the sample following injection [49]. As shown, the time course of the voltammetric measurement for a 5-s injection of hydrogen peroxide in a flow injection analysis experiment can be obtained by averaging the oxidative current of each cyclic voltammogram (repeated at a 200 ms interval) between 800-1 100 mV.…”

Section: Fast Scan Cyclic Voltammetry For Hydrogen Peroxidementioning

confidence: 99%

Detection of hydrogen peroxide and other molecules of biologicl importance at an electrocataltic surface on a carbon fiber microelectrode

Nowall

Kuhr

1997

Electroanalysis

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The electrocatalytic oxidation of hydrogen peroxide in solution at a modified carbon fiber electrode has been investigated. A simple electrochemical procedure has been developed to dramatically improve the voltammetry for the oxidation of peroxide, NADH, and several other species under steady state and fast scan voltammetry. The surface is generated by the electrochemical oxidation of NADH followed by exposure to peroxide. This procedure yields a surface which is sensitive to peroxide and stable in air for more than 90 days. This oxidation occurs at a potential such that it is easily discriminated from the analytes tested in this study.

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Temporal characterization of perfluorinated ion exchange coated microvoltammetric electrodes for in vivo use

Cited by 259 publications

References 40 publications

Electrochemical sensors: a powerful tool in analytical chemistry

Electrochemical sensors: a powerful tool in analytical chemistry

Multimembrane Carbon Fiber Electrodes for Physiological Measurements of Nitric Oxide

Detection of hydrogen peroxide and other molecules of biologicl importance at an electrocataltic surface on a carbon fiber microelectrode

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