1997
DOI: 10.1523/jneurosci.17-16-06264.1997
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Temporal Correlations between Functional and Molecular Changes in NMDA Receptors and GABA Neurotransmission in the Superior Colliculus

Abstract: Activation of the NMDA subtype of glutamate receptor is required for activity-dependent structural plasticity in many areas of the young brain. Previous work has shown that NMDA receptor currents decline approximately at the time that developmental synaptic plasticity ends, and in situ hybridization studies have suggested that receptor subunit changes may be occurring during the same developmental interval. To establish a system in which the relationship between these properties of developing synapses can be e… Show more

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Cited by 110 publications
(138 citation statements)
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“…In WT mice, spontaneous excitatory postsynaptic potentials and spon͞mini NMDARc amplitudes remained constant between P8 and P13 ( Fig. 1 A and B) (2). In this interval spon͞mini NMDARcs in the NR2AKO showed a progressive decay in amplitude terminating at ϳP13, when NMDARcs were indistinguishable from baseline noise (Ͻ3 pA at Ϫ70 mV; Fig.…”
Section: Resultsmentioning
confidence: 84%
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“…In WT mice, spontaneous excitatory postsynaptic potentials and spon͞mini NMDARc amplitudes remained constant between P8 and P13 ( Fig. 1 A and B) (2). In this interval spon͞mini NMDARcs in the NR2AKO showed a progressive decay in amplitude terminating at ϳP13, when NMDARcs were indistinguishable from baseline noise (Ͻ3 pA at Ϫ70 mV; Fig.…”
Section: Resultsmentioning
confidence: 84%
“…Film exposures were in the linear range for all bands being compared. Band density was quantified as described by using NIH IMAGE and its gel-plotting macros (2). At least three separate protein isolations were made at all time points and averaged for quantitation.…”
Section: Methodsmentioning
confidence: 99%
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“…In addition, SC interneurons undergo well characterized and precisely timed developmental changes in synaptic transmission. At the end of the second postnatal week (P13-P14), when visual activity increases with retinal maturation and eye-opening, frequency of spontaneous synaptic activity mediated by AMPARs (sAMPA) and GABA A Rs (sGABA) increases, whereas NMDAR currents (sNMDAs) decay faster because of a change in the composition from NR2B-rich to NR2A-rich receptors (Shi et al, 1997Aamodt et al, 2000;Colonnese et al, 2003;Lu and Constantine-Paton, 2004;Townsend et al, 2004;van Zundert et al, 2004). The dependence of these synaptic changes on neural activity led us to predict that hyperactivity would be associated with accelerated development of synaptic transmission in hSOD1 G93A mice.…”
Section: G93a Motoneurons and Interneurons As In Fals Patients Hsod1mentioning
confidence: 99%
“…Evidence in a number of systems shows that activation of NMDARs can influence the effectiveness of GABAergic inputs. For example, maturation of GABA currents in rat SC may be regulated by NMDAR activity (Shi et al, 1997;Aamodt et al, 2000;Henneberger et al, 2005), and NMDA receptor activation can lead to long-term depression of GABAergic synapses in Xenopus tectum (Lien et al, 2006). Thus, changes in the strength of GABAergic synapses can result from the developmental or experimental modification of NMDAR activity.…”
Section: Discussionmentioning
confidence: 99%