Temporal course of avascular femoral head necrosis in patients with pemphigus vulgaris

Balighi, Kamran; Daneshpazhooh, Maryam; Aghazadeh, Nessa; Saeidi, Vahide; Shahpouri, Farzam; Hejazi, Pardis; Chams‐Davatchi, Cheyda

doi:10.1111/ddg.13079

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…The use of MRI screening for diagnosing AVN and the sample size of non-SLE rheumatologic disorders was small, which may have resulted in the high rate of AVN observed by Shigemura et al [ 17 ]. For pemphigus, the results of the current study are comparable with those of a previous Iranian epidemiology survey (1.93%) [ 21 ]. In the present study, the low rate of AVN in patients with RA is similar to a study conducted by Klippel et al [ 6 ].…”

Section: Discussionsupporting

confidence: 88%

Epidemiology and risk factors associated with avascular necrosis in patients with autoimmune diseases: a nationwide study

Tsai

Chang

et al. 2022

Korean J Intern Med

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Background/Aims: Avascular necrosis (AVN) is a clinical condition characterized by the death of bone components due to interruption in the blood supply. This study aimed to investigate the epidemiology and determine the risk factors for AVN in patients with autoimmune diseases. Methods: We conducted a population-based retrospective cohort analysis using claims data from the Taiwan National Health Insurance Research Database. A total of 49,636 patients with autoimmune diseases between January 1, 2005 and December 31, 2013 were included. Cox regression analysis was used to identify associated risk factors for the development of AVN. Results: A total of 490/49,636 patients (1.0%) developed symptomatic AVN. The systemic lupus erythematosus patients had a higher risk of AVN compared to other autoimmune diseases. AVN was positively correlated with male sex (p < 0.001), alcoholism (p < 0.001), mean daily prednisolone dosage 7.51 to 30 mg (p < 0.001) and > 30 mg (p < 0.001), and total cumulative prednisolone dose 0 g to 5 g (p = 0.002). However, AVN was inversely correlated with cumulative duration of hydroxychloroquine exposure > 0.6 years (p < 0.001). Conclusions: Male sex, systemic lupus erythematosus, alcoholism, mean daily corticosteroid > 7.5 mg and a total cumulative dose of corticosteroid 0 to 5 g were independently associated with the development of AVN in autoimmune patients. While hydroxychloroquine use > 0.6 years conferred significant protection against the development of AVN. Clinicians should regularly assess patients with risk factors to enable the early diagnosis of AVN.

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Section: Discussionsupporting

confidence: 88%

Epidemiology and risk factors associated with avascular necrosis in patients with autoimmune diseases: a nationwide study

Tsai

Chang

et al. 2022

Korean J Intern Med

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“…Because of the large area of skin erosion, massive body fluid extravasation, and excessive loss of proteins, electrolytes and body fluids, pemphigus causes physical weakness, and pemphigus patients easily develop cormorbid sepsis, pneumonia, and other infections [ 11 , 12 ], which are also the main causes of death [ 13 ]. According to clinical investigations, therapy of pemphigus may also cause complications such as kidney disease, femoral head necrosis, hypertension, diabetes, and digestive tract diseases [ [14] , [15] , [16] ].…”

Section: Introductionmentioning

confidence: 99%

“…The strategy of pemphigus treatment is to control the occurrence of new lesions and prevent recurrence. This is accomplished mainly through supportive treatment and drug treatment alongside the prevention and treatment of complications [ 14 ]. The general treatment is to provide strong supportive therapy and encourage the consumption of a nutritious and digestible diet.…”

Section: Introductionmentioning

confidence: 99%

Focus on pemphigus treatment publications: A bibliometric and visual analysis (1992–2022)

Wang,

Huang,

et al. 2024

Heliyon

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“…Steroids can cause the death of bone dynamics components and are the most common cause of ONFH ( 2 , 3 ). Long-term high-dose use of glucocorticoids is the key risk factor for nontraumatic femoral head necrosis ( 4 , 5 ), which was known as steroid-induced osteonecrosis of the femoral head (SONFH). With the widespread use of glucocorticoids in the treatment of rheumatic immune diseases ( 6 , 7 ), SONFH was commonly seen in clinical, with the incidence up to 40% ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

Global research trends of steroid-induced osteonecrosis of the femoral head: A 30-year bibliometric analysis

Lü¹,

Qi²,

Xu³

et al. 2022

Front. Endocrinol.

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ObjectiveTo explore the global research trends and hotspots of steroid-induced osteonecrosis of the femoral head (SONFH) through qualitative and quantitative analysis of bibliometrics.MethodsAll publications on SONFH published from 1992 to 2021 were extracted from the Web of Science Core Collection database. CiteSpace was used for the visualization analysis of major countries, active institutions, productive authors, and the burst of keywords. VOSviewer was used for coupling analysis of countries/regions, institutions, and authors. Microsoft Excel 2017 was used for statistical analysis, drawing bar charts, pie charts, and cumulative area charts. The software of MapInfo was used to draw the distribution map of the publications.ResultsA total of 780 publications were included for analyses. The most productive year was 2020 with 98 records. China was the most influential country with 494 publications, an H-index of 59, and total citations of 16820. The most prolific institution was Shanghai Jiaotong University in China with 53 publications and 998 citations. Clinical Orthopaedics and Related Research (IF = 4.755, 2021) was the most active journal with 26 articles. The hot keywords were “osteonecrosis”, “avascular necrosis”, “osteogenic differentiation”, “proliferation”, “PPAR gamma”, “apoptosis”, “oxidative stress”, “genetic polymorphism” and “mesenchymal stem cells”. The keywords like “proliferation”, “PPAR gamma” and “genome-wide” have emerged in recent years.ConclusionThe number of publications in SONFH has increased significantly in the last three decades. The pathologic mechanism of SONFH gathered most research interests. Genomics and cell molecular biology of SONFH are the research frontiers.

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Temporal course of avascular femoral head necrosis in patients with pemphigus vulgaris

Abstract: Occurring in about 2 % of patients, AVN is a serious complication of corticosteroid treatment in patients with PV, predominantly in the first three years of treatment. In individuals receiving higher doses of prednisolone, AVN tends to occur earlier.

Cited by 3 publications

References 32 publications

Epidemiology and risk factors associated with avascular necrosis in patients with autoimmune diseases: a nationwide study

Epidemiology and risk factors associated with avascular necrosis in patients with autoimmune diseases: a nationwide study

Focus on pemphigus treatment publications: A bibliometric and visual analysis (1992–2022)

Global research trends of steroid-induced osteonecrosis of the femoral head: A 30-year bibliometric analysis

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