Temporal course of peripheral inflammation markers and indexes following acute ischemic stroke: prediction of mortality, functional outcome, and stroke-associated pneumonia

Adigüzel, Ahmet; Arsava, Ethem Murat; Topçuoğlu, Mehmet Akif

doi:10.1080/01616412.2021.1975222

Cited by 23 publications

(15 citation statements)

References 34 publications

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“…Numerous studies have drawn attention to the role of neuroinflammation in ischemic stroke [12][13][14] . NLR, neutrophil, leukocyte and platelet counts are significantly associated with survival in acute ischemic stroke 15 . NLR and PNR have recently been reported as potential new biomarkers of the initial inflammatory process and are predictors of prognosis in patients with ischemic stroke [16][17][18][19][20] .…”

Section: Discussionmentioning

confidence: 96%

The Effect of Neutrophil to Lymphocyte and Neutrophil to Platelet Ratios on Prognosis in Stroke Patients

BOZ¹,

BOZ²,

ACAR

et al. 2022

Dicle Tıp Dergisi

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Background: The aim of this study is to determine the correlation of neuroinflammatory response biomarkers neutrophil to lymphocyte ratio (NLR), neutrophil to platelet ratio (NPR) with risk factors, etiology, and prognosis in stroke patients. Methods: Cases diagnosed with ischemic stroke were recruited in this study. Demographic data, comorbidities, laboratory findings, carotid doppler ultrasonography, NIHSS (National Institutes of Health Stroke Scale) and MRS (modified rankin scale) scores of the cases were documented. Afterwards, the cases were divided into 3 groups (posterior circulation infarct, anterior circulation infarct, and lacunar infarct). Results: A total of 133 patients, 65 female and 68 males, aged between 24 and 94 were included in this study. At the end of hospitalization, NLR (p=0.001) and NPR (p=0.007) were significantly found high in patients with unfavorable functional outcome (MRS≥3) and those who died compared to NLR (p=0.001) and NPR (p=0.008) in the favorable functional outcome group. The NLR cut-off value for unfavorable functional outcome (95% confidence interval lower limit of area-under-curve of ROC≥0.7) was found to be 4.0. Conclusion: High NLR and NPR values measured at first admission in patients with acute ischemic stroke are highly associated with unfavorable functional outcome and mortality, and NLR and NPR are important prognostic biomarkers in patients with acute ischemic stroke.

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Section: Discussionmentioning

confidence: 96%

The Effect of Neutrophil to Lymphocyte and Neutrophil to Platelet Ratios on Prognosis in Stroke Patients

BOZ¹,

BOZ²,

ACAR

et al. 2022

Dicle Tıp Dergisi

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“… 41–43 Elevated SII levels suggest a poor prognosis. 44 Similarly, SIRI is a new type of inflammatory index. And numerous studies have shown that it can be a good predictor of prognosis in patients with tumors.…”

Section: Discussionmentioning

confidence: 99%

The Association of Inflammatory Markers with Maternal-Neonatal Outcome After Cervical Cerclage

Fang

Lin

Chen

et al. 2023

JIR

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Objective Cervical cerclage is effective in prolonging the number of weeks gestation in patients with cervical insufficiency(CI). However, valuable predictors with successful cervical cerclage remain limited. It aimed to evaluate the value of the systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) to predict the outcomes of cervical cerclage. Methods This study analyzed 374 participants. Inflammatory markers were calculated using maternal peripheral blood. The association of inflammatory markers and the outcome of cervical cerclage were analyzed. And the optimal cut-off values of inflammatory markers were calculated. Also, the Chi-square test and logistic and linear regression analyses were performed to evaluate inflammatory markers with the maternal outcome and neonatal outcomes. Results 374 pregnancies were included in this study. Finally, 268 (71.7%) participants suffered successful cervical cerclage. This study demonstrated that the baseline BMI (cm 2 /kg), the bulging membrane, cervical dilation (≥2cm), the amniotic sac herniation, the neutrophils counts, the systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) were significant difference between the successful and unsuccessful groups (all P<0.05). Additionally, maternal blood inflammatory markers, such as WBC, lymphocyte, neutrophils, monocyte, platelet counts, SII, and SIRI, were significantly associated with maternal-neonatal outcomes. Furthermore, the results demonstrated that the SII level had the highest OR (OR=4.626; 95% CI (2.500–8.560)), as well as the following: SIRI level (OR = 3.795; 95% CI (1.989–7.242)), cervical dilation (≥2cm) (OR =3.477; 95% CI (1.458–10.844)), and amniotic sac herniation (OR = 1.796; 95% (0.473–4.975)). Conclusion This study demonstrated that the baseline SII level and SIRI level are important biochemical markers for predicting the outcome of cervical cerclage and maternal-neonatal outcomes with non-invasive procedures. They can help to provide personalized treatment before surgery and enhance postoperative surveillance.

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“…Adiguzel et al. ( 21 ) showed that significant variations of SII were observed during the first two weeks following the stroke. However, due to age and post-treatment clinical stroke severity, the discriminative capacity of these changes was limited.…”

Section: Discussionmentioning

confidence: 99%

Association of the systemic immune-inflammation index (SII) and clinical outcomes in patients with stroke: A systematic review and meta-analysis

Huang

2022

Front. Immunol.

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IntroductionA novel systemic immune-inflammation index (SII) has been proven to be associated with outcomes in patients with cancer. Although some studies have shown that the SII is a potential and valuable tool to diagnose and predict the advise outcomes in stroke patients. Nevertheless, the findings are controversial, and their association with clinical outcomes is unclear. Consequently, we conducted a comprehensive review and meta-analysis to explore the relationship between SII and clinical outcomes in stroke patients.MethodsA search of five English databases (PubMed, Embase, Cochrane Library, Scopus, and Web of Science) and four Chinese databases (CNKI, VIP, WanFang, and CBM) was conducted. Our study strictly complied with the PRISMA (the Preferred Reporting Items for Systematic Reviews and Meta-Analyses). We used the NOS (Newcastle-Ottawa Scale) tool to assess the possible bias of included studies. The endpoints included poor outcome (the modified Rankin Scale [mRS] ≥ 3 points or > 3 points), mortality, the severity of stroke (according to assessment by the National Institute of Health stroke scale [NIHSS] ≥ 5 points), hemorrhagic transformation (HT) were statistically analyzed.ResultsNineteen retrospective studies met the eligibility criteria, and a total of 18609 stroke patients were included. Our study showed that high SII is significantly associated with poor outcomes (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.02-1.09, P = 0.001, I2 = 93%), high mortality (OR 2.16, 95% CI 1.75-2.67, P < 0.00001, I2 = 49%), and the incidence of HT (OR 2.09, 95% CI 1.61-2.71, P < 0.00001, I2 = 42%). We also investigated the difference in SII levels in poor/good outcomes, death/survival, and minor/moderate-severe stroke groups. Our analysis demonstrated that the SII level of the poor outcome, death, and moderate-severe stroke group was much higher than that of the good outcome, survival, and minor stroke group, respectively (standard mean difference [SMD] 1.11, 95% CI 0.61-1.61, P < 0.00001 [poor/good outcome]; MD 498.22, 95% CI 333.18-663.25, P < 0.00001 [death/survival]; SMD 1.35, 95% CI 0.48-2.23, P = 0.002 [severity of stroke]). SII, on the other hand, had no significant impact on recanalization (OR 1.50, 95% CI 0.86-2.62, P = 0.16).DiscussionTo the best of our knowledge, this may be the first meta-analysis to look at the link between SII and clinical outcomes in stroke patients. The inflammatory response after a stroke is useful for immunoregulatory treatment. Stroke patients with high SII should be closely monitored, since this might be a viable treatment strategy for limiting brain damage after a stroke. As a result, research into SII and the clinical outcomes of stroke patients is crucial. Our preliminary findings may represent the clinical condition and aid clinical decision-makers. Nonetheless, further research is needed to better understand the utility of SII through dynamic monitoring. To generate more robust results, large-sample and multi-center research are required.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022371996.

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Temporal course of peripheral inflammation markers and indexes following acute ischemic stroke: prediction of mortality, functional outcome, and stroke-associated pneumonia

Cited by 23 publications

References 34 publications

The Effect of Neutrophil to Lymphocyte and Neutrophil to Platelet Ratios on Prognosis in Stroke Patients

The Effect of Neutrophil to Lymphocyte and Neutrophil to Platelet Ratios on Prognosis in Stroke Patients

The Association of Inflammatory Markers with Maternal-Neonatal Outcome After Cervical Cerclage

Association of the systemic immune-inflammation index (SII) and clinical outcomes in patients with stroke: A systematic review and meta-analysis

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