Temporal Dementia and Cognitive Impairment Trends in the Very Old in the 21st Century

Weidung, Bodil; Lövheim, Hugo; Littbrand, Håkan; Wahlin, Johanna; Gustafson, Yngve

doi:10.3233/jad-220915

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…Vascular dementia is a neurodegenerative condition resulting from brain damage caused by disruptions in blood flow to the brain, leading to significant impacts on cognitive and psychomotor functions [ 1 , 2 , 3 ]. It represents the second most common type of dementia after Alzheimer’s disease (AD), affecting approximately 46.8 million individuals worldwide and contributing to at least 20–25% of total dementia cases [ 4 , 5 ]. Its incidence doubles every 5–10 years from the age of sixty-five [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Does Transcranial Direct Current Stimulation Affect Potential P300-Related Events in Vascular Dementia? Considerations from a Pilot Study

Gangemi,

Fabio,

Suriano

et al. 2024

Biomedicines

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Vascular dementia, the second most common type of dementia, currently lacks a definitive cure. In the pursuit of therapies aimed at slowing its progression and alleviating symptoms, transcranial direct current stimulation (tDCS) emerges as a promising approach, characterized by its non-invasive nature and the ability to promote brain plasticity. In this study, the primary objective was to investigate the effects of a two-week cycle of tDCS on the dorsolateral prefrontal cortex (DLPFC) and neurophysiological functioning in thirty patients diagnosed with vascular dementia. Each participant was assigned to one of two groups: the experimental group, which received anodal tDCS to stimulate DPCFL, and the control group, which received sham tDCS. Neurophysiological functions were assessed before and after tDCS using P300 event-related potentials (ERPs), while neuropsychological function was evaluated through a Mini-Mental State Examination (MMSE). The results showed a reduction in P300 latency, indicating a faster cognitive process; an increase in P300 amplitude, suggesting a stronger neural response to cognitive stimuli; and a significant improvement in MMSE scores compared to the control group, indicating an overall enhancement in cognitive functions. These findings suggest that tDCS could represent a promising therapeutic option for improving both neurophysiological and cognitive aspects in patients with vascular dementia.

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Section: Introductionmentioning

confidence: 99%

Does Transcranial Direct Current Stimulation Affect Potential P300-Related Events in Vascular Dementia? Considerations from a Pilot Study

Gangemi,

Fabio,

Suriano

et al. 2024

Biomedicines

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Prevalence of depressive disorders among the very old in the 21st century

Corneliusson,

Gustafson,

Olofsson

2024

Journal of Affective Disorders

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Prevalence of heart failure and trends in its pharmacological treatment between 2000 and 2017 among very old people

Svahn,

Appelblad,

Lövheim

et al. 2024

BMC Geriatr

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Purpose The aim of this study was to describe a population of very old people with heart failure (HF), to analyse the use of cardiovascular drugs over time, and to explore factors influencing cardiovascular drug treatment for this group. Methods All participants with information regarding HF diagnosis were selected from the Umeå 85+/Gerontological Regional Database (GERDA). The people in GERDA are all ≥85 years old. Trained investigators performed structured interviews and assessments. Information regarding medications and diagnoses was obtained from the participants and from medical records. Medical diagnoses were reviewed and confirmed by an experienced geriatrician. Results In this very old population, the prevalence of HF was 29.6% among women and 30.7% among men. Between 2000 and 2017, there was an increase in the use of renin-angiotensin (RAS) inhibitors (odds ratio [OR] 1.107, 95% confidence interval [CI] 1.072–1.144) and beta-blockers (BBs) (OR 1.123, 95% CI 1.086–1.161) among persons with HF, whereas the prevalence of loop diuretics (OR 0.899, 95% CI 0.868–0.931) and digitalis (OR 0.864, 95% CI 0.828–0.901) decreased (p < 0.001 for all drug classes). Higher age was associated with lower use of RAS inhibitors and BBs. Conclusion In this HF population, the use of evidence-based medications for HF increased over time. This may be a sign of better awareness among prescribers regarding the under-prescribing of guidelines-recommended treatment to old people. Higher age associated with a lower prevalence of RAS inhibitors and BBs. This might indicate that further improvement is possible but could also represent a more cautious prescribing among frail very old individuals.

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Temporal Dementia and Cognitive Impairment Trends in the Very Old in the 21st Century

Cited by 3 publications

References 53 publications

Does Transcranial Direct Current Stimulation Affect Potential P300-Related Events in Vascular Dementia? Considerations from a Pilot Study

Does Transcranial Direct Current Stimulation Affect Potential P300-Related Events in Vascular Dementia? Considerations from a Pilot Study

Prevalence of depressive disorders among the very old in the 21st century

Prevalence of heart failure and trends in its pharmacological treatment between 2000 and 2017 among very old people

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