Temporal development of the infant oral microbiome

Blum, Jordan; Silva, Mihiri; Byrne, Samantha J.; Butler, Catherine A.; Adams, Geoff; Reynolds, Eric C.; Dashper, Stuart G.

doi:10.1080/1040841x.2021.2025042

Cited by 8 publications

(7 citation statements)

References 92 publications

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“…We observed that Streptococcus species were more abundant in the healthy controls than the preterm babies at early stages. Moreover, various findings demonstrated the reduction in Streptococcus abundance was accompanied by enhanced microbial diversity ( Blum et al, 2022 ). In addition, this decreasing phenomenon of Streptococcus was observed in our study, which may be because of bacterial community development.…”

Section: Discussionmentioning

confidence: 99%

“…Members of Streptococcus can bind to other bacteria via surface adhesins, which can promote the development of certain bacterial communities, and occur together with G. haemolysans , and R. mucilaginosa ( Kolenbrander et al, 2006 ; Nobbs et al, 2011 ; Sulyanto et al, 2019 ). In addition, the facultative anaerobic, Gram-positive diplococcus G. haemolysans primarily mucosal in mammals, particularly in the upper gastrointestinal tract with the oral cavity, and ferments free sugars into a mixture of acidic end products ( Blum et al, 2022 ). This was associated with allergies in the oral microbiome of children ( Dzidic et al, 2018 ), which were not found in our questionnaire analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, birth weight and gestational weeks at birth presented a significant association with the bacterial community. Protective factors of breast milk, such as maternal sIgA, may stimulate colonization with commensal bacteria, which perform an essential function in fulfilling the critical tasks required to build a microbial community to establish a healthy microbiota profile in the oral cavity ( Berger et al, 2020 ; Blum et al, 2022 ). Cheema et al (2022) indicated that the ingestion of oligosaccharides from human milk was associated with infant oral and fecal taxa, while their direct clinical relevance was unknown.…”

Section: Discussionmentioning

confidence: 99%

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Microbiota of preterm infant develops over time along with the first teeth eruption

Wu¹,

Feng²,

Cao³

et al. 2022

Front. Microbiol.

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ObjectiveThe temporal growth of the infant microbiome in the early years of life influences short- and long-term infant health. The aim of this longitudinal study was to investigate bacterial dynamics in the microbiome of preterm infants during tooth eruption.MethodsSaliva samples from normally delivered (n = 24) and preterm infants (n = 31) were collected 30 days after birth and after the eruption of two primary mandibular incisors. Based on Illumina MiSeq Sequencing of the 16S rRNA gene, the dynamic microbial changes of newborns at two-time points were investigated. Meanwhile, the Human Oral Microbiome Database was adopted for assigning taxonomy.ResultsUsing alpha and beta diversity analyses, different shift patterns of microbiome structures in preterm and healthy participants and bacterial diversity over time were observed. The relative abundance and shifts trend, along with the two lower primary central incisors eruption, of core oral flora varies in full-term and preterm groups, including Gemella spp., Rothia mucilaginosa, Veillonella atypica, etc. Several microorganisms colonize later in the oral microbiome development of premature babies, such as Gemella spp. In addition to teeth eruption, the growth of the saliva microbiome in preterm infants could be influenced by breastfeeding durations and birth weight.ConclusionThis study provided insights into how the oral microbiota changes during tooth eruption in preterm infants and how the colonization of the oral cavity with bacteria in preterm infants differs significantly from that in full-term infants.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Microbiota of preterm infant develops over time along with the first teeth eruption

Wu¹,

Feng²,

Cao³

et al. 2022

Front. Microbiol.

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“…Dental surfaces acquire a glycoprotein coat, also known as acquired pellicle, that shifts the colonization patterns [70] . Gingival sulci and interproximal spaces between teeth further contribute to the diversity of environments in the oral cavity for microbial colonization and growth, rich in serum and acids and poor in saliva and oxygen [71] , [72] . After teeth eruption, planktonic bacteria bind to proteins of the acquired pellicle, resulting in polymicrobial biofilm formation [70] .…”

Section: Teeth Eruption and Diet Changesmentioning

confidence: 99%

The contribution of maternal factors to the oral microbiota of the child: Influence from early life and clinical relevance

Azevedo

García

Costa

et al. 2023

Japanese Dental Science Review

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“…Current evidence suggests that similar to the adult oral microbiome, the infant oral microbiome is dominated by Streptococcus ( Drell et al, 2017 ; Verma et al, 2018 ). It is also comprised largely of facultative anaerobes such as Gemella, Rothia, Haemophilus, and Lactobacillus ( Blum et al, 2022 ). After birth, the neonatal oral microbiome is dominated by Streptococcaceae, Staphylococcaceae, Gemellaceae, Pasteurellaceae, and Lactobacillales ( Gomez-Arango et al, 2017 ; Dashper et al, 2019 ; Sulyanto et al, 2019 ; Williams et al, 2019 ; Holgerson et al, 2020 ; Cheema et al, 2022 ).…”

Section: Composition and Temporal Development Of The Infant Oral Micr...mentioning

confidence: 99%

Impact of breastfeeding and other early-life factors on the development of the oral microbiome

Arishi,

Lai,

Geddes

et al. 2023

Front. Microbiol.

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The oral cavity is home to the second most diverse microbiome in the human body. This community contributes to both oral and systemic health. Acquisition and development of the oral microbiome is a dynamic process that occurs over early life; however, data regarding longitudinal assembly of the infant oral microbiome is scarce. While numerous factors have been associated with the composition of the infant oral microbiome, early feeding practices (breastfeeding and the introduction of solids) appear to be the strongest determinants of the infant oral microbiome. In the present review, we draw together data on the maternal, infant, and environmental factors linked to the composition of the infant oral microbiome, with a focus on early nutrition. Given evidence that breastfeeding powerfully shapes the infant oral microbiome, the review explores potential mechanisms through which human milk components, including microbes, metabolites, oligosaccharides, and antimicrobial proteins, may interact with and shape the infant oral microbiome. Infancy is a unique period for the oral microbiome. By enhancing our understanding of oral microbiome assembly in early life, we may better support both oral and systemic health throughout the lifespan.

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Temporal development of the infant oral microbiome

Cited by 8 publications

References 92 publications

Microbiota of preterm infant develops over time along with the first teeth eruption

Microbiota of preterm infant develops over time along with the first teeth eruption

The contribution of maternal factors to the oral microbiota of the child: Influence from early life and clinical relevance

Impact of breastfeeding and other early-life factors on the development of the oral microbiome

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