Fires are becoming increasingly frequent, intense, severe and prolonged worldwide, and such situation is worsening. As a result, extreme fire conditions will increase, with consequences for wildlife, including increased mass mortality and changes in trophic relationships in natural communities. This intensification is expected to be particularly pronounced in the Mediterranean ecosystems. In this scoping review, we summarized current knowledge and gaps in understanding the effects of fires on wildlife, focusing on predator–prey interactions. These interactions play a critical role in animal communities and their understanding is fundamental for appropriate management and conservation. Mammals were chosen as a model group because of their remarkable ecological role. We grouped and analysed the post-wildfire changes in the predator–prey relationships into three-time intervals: immediate, short- and long-term effects. This is relevant as vegetation restoration, by altering cover and habitat structure, may affect hunting strategies and anti-predatory behaviour. Our review showed that studies generally had several limitations, the most common of which were the lack of replication, the strong geographical bias, and the focus on few target species. Nevertheless, we could formally describe how fire affects predator–prey relationships in Mediterranean ecosystems through processes that exert different cascading effects at different times after the fire event. We encourage long-term studies on communities, including as many components of the food chain as possible, using an interdisciplinary approach, and prioritising investigations in high-risk ecosystems.