2024
DOI: 10.3389/fimmu.2024.1352819
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Temporal dynamics of immune-stromal cell interactions in fracture healing

Christina A. Capobianco,
Kurt D. Hankenson,
Alexander J. Knights

Abstract: Bone fracture repair is a complex, multi-step process that involves communication between immune and stromal cells to coordinate the repair and regeneration of damaged tissue. In the US, 10% of all bone fractures do not heal properly without intervention, resulting in non-union. Complications from non-union fractures are physically and financially debilitating. We now appreciate the important role that immune cells play in tissue repair, and the necessity of the inflammatory response in initiating healing afte… Show more

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