Temporal effects of laparoscopic sleeve gastrectomy on adipokines, inflammation, and oxidative stress in patients with impaired glucose homeostasis

Stephens, Jeffrey W.; Min, Thinzar; Dunseath, Gareth; Churm, Rachel; Barry, Jonathan; Prior, Sarah L.

doi:10.1016/j.soard.2019.04.006

Cited by 11 publications

(9 citation statements)

References 38 publications

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“…This might be explained by a small sample size. In our recent published study comprising 55 participants with impaired glucose regulation, we observed a significant increase in serum adiponectin level at 6 months following SG [7]. Within the SG group, there was a significant increase in fasting TBARS as well as fasting TAOS.…”

Section: Discussionmentioning

confidence: 56%

“…Our previous work demonstrated that SG was associated with improvement in inflammation and oxidative stress in 55 participants with impaired glucose regulation [7]. The primary aim of the current study was to examine the long-term (4 years) effects of bariatric surgery on adipokines (adiponectin, leptin), inflammatory cytokines (CRP, IL-6, IL-10) and global plasma measures of oxidative stress (thiobarbituric acid reactive substances [TBARS] and total antioxidant status [TAOS]) regardless of operation types.…”

Section: Introductionmentioning

confidence: 96%

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Temporal Effects of Bariatric Surgery on Adipokines, Inflammation and Oxidative Stress in Subjects with Impaired Glucose Homeostasis at 4 Years of Follow-up

et al. 2020

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Background Previous studies have examined changes in plasma markers of inflammation and oxidative stress up to 24 months following bariatric surgery, but there is limited evidence on the long-term effects of bariatric surgery. Objectives To examine the effects of bariatric surgery on adipokines (adiponectin, leptin), inflammatory cytokines [C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-10(IL-10)] and global plasma measures of oxidative stress [thiobarbituric acid reactive substances (TBARS) and total antioxidant status (TAOS) 1 and 6 months, and 4 years post-surgery in subjects with obesity and impaired glucose regulation. Methods A prospective study comprising of 19 participants (13 females, mean age 50.4 ± 6.2 years, mean body mass index (BMI) 54 ± 14 kg/m 2 , 17 type 2 diabetes) undergoing bariatric surgery (10 sleeve gastrectomy, 6 biliopancreatic diversion, 2 Roux-en-Y gastric bypass and 1 laparoscopic adjustable gastric banding). Serial measurements of the above markers were made pre-operatively, 1 and 6 months and 4 years post-operatively. Results Compared to pre-operative levels, significant decreases were seen 4 years post-operatively in CRP (11.4 vs 2.8 ng/mL, p < 0.001), IL-6 (8.0 vs 2.1 pg/mL, p < 0.001) and leptin (60.7 vs 32.1 pg/mL, p = 0.001). At 4 years, both fasting and 120 min TAOS significantly increased by 35% and 19% respectively. However, fasting and 120 min TBARS did not show any significant changes. Conclusion To our knowledge, no other studies have described changes in inflammation and oxidative stress at 4 years following bariatric surgery. This study contributes to the current literature supporting the longer-term beneficial effect of bariatric surgery on chronic inflammation and oxidative stress.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 96%

Temporal Effects of Bariatric Surgery on Adipokines, Inflammation and Oxidative Stress in Subjects with Impaired Glucose Homeostasis at 4 Years of Follow-up

et al. 2020

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“…Given that improved gut barrier function and decreased permeability prevent translocation of inflammation from intestine into circulation and periphery ( 33 ), it is therefore possible that the improvements of pro-inflammation and gut barrier function in the colon following SG contribute to an overall relief of inflammatory condition observed in obesity. Interestingly, previous studies have revealed that patients who underwent SG experience decreased levels of pro-inflammatory cytokines in the circulation and liver following surgery ( 25 , 39 ). Collectively, these data suggest that SG results in improvements in the HFD feeding associated colonic pro-inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…These microbes are generally regarded as “healthy” bacteria and can be found in a variety of foods and probiotics which are often used to treat intestinal health issues ( 44 , 45 ). Previous studies have indicated that administration of probiotics containing multiple Lactobacillus strains reduces inflammation and enhances gut barrier function in obese mice ( 39 , 46 ). Additionally, certain bacteria that promote inflammation such as Desulfovibrio ( 47 ) were found decreased in abundance following SG.…”

Section: Discussionmentioning

confidence: 99%

Sleeve gastrectomy decreases high-fat diet induced colonic pro-inflammatory status through the gut microbiota alterations

et al. 2023

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BackgroundHigh-fat diet (HFD) induced obesity is characterized with chronic low-grade inflammation in various tissues and organs among which colon is the first to display pro-inflammatory features associated with alterations of the gut microbiota. Sleeve gastrectomy (SG) is currently one of the most effective treatments for obesity. Although studies reveal that SG results in decreased levels of inflammation in multiple tissues such as liver and adipose tissues, the effects of surgery on obesity related pro-inflammatory status in the colon and its relation to the microbial changes remain unknown.MethodsTo determine the effects of SG on the colonic pro-inflammatory condition and the gut microbiota, SG was performed on HFD-induced obese mice. To probe the causal relationship between alterations of the gut microbiota and improvements of pro-inflammatory status in the colon following SG, we applied broad-spectrum antibiotics cocktails on mice that received SG to disturb the gut microbial changes. The pro-inflammatory shifts in the colon were assessed based on morphology, macrophage infiltration and expressions of a variety of cytokine genes and tight junction protein genes. The gut microbiota alterations were analyzed using 16s rRNA sequencing. RNA sequencing of colon was conducted to further explore the role of the gut microbiota in amelioration of colonic pro-inflammation following SG at a transcriptional level.ResultsAlthough SG did not lead to pronounced changes of colonic morphology and macrophage infiltration in the colon, there were significant decreases in the expressions of several pro-inflammatory cytokines including interleukin-1β (IL-1β), IL-6, IL-18, and IL-23 as well as increased expressions of some tight junction proteins in the colon following SG, suggesting an improvement of pro-inflammatory status. This was accompanied by changing populations of the gut microbiota such as increased richness of Lactobacillus subspecies following SG. Importantly, oral administrations of broad-spectrum antibiotics to delete most intestinal bacteria abrogated surgical effects to relieve colonic pro-inflammation. This was further confirmed by transcriptional analysis of colon indicating that SG regulated inflammation related pathways in a manner that was gut microbiota relevant.ConclusionThese results support that SG decreases obesity related colonic pro-inflammatory status through the gut microbial alterations.

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“…The evident decrease in inflammatory parameters occurred after significant weight loss and was related to the postoperative period, i.e. > 6 months after laparoscopic sleeve gastrectomy 20 , 21 . NAFLD is characterized by an excessive fat accumulation in the hepatocytes of people who do not consume alcohol and presents as a wide range of asymptomatic diseases, steatosis necroinflammatory forms of the disease or non-alcoholic steatohepatitis (NASH).…”

Section: Introductionmentioning

confidence: 97%

Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats

Stygar

Sawczyn

Dulska

et al. 2021

Sci Rep

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We studied the long-term effect of ileal transposition (IT) metabolic surgery on the hepatokines: retinol-binding protein-4 (RBP4), α-2-HS-glycoprotein (aHSG/fetuin-A), and fibroblast growth factor 21 (FGF21), C-reactive protein (CRP) plasma levels, glucose metabolism, body weight, liver histology, as well as total lipids concentration in muscle, liver, and fat tissue of obese Zucker (Crl:ZUC(ORL)-Leprfa) rats. 14 adult males were randomly submitted either to IT or SHAM (control) surgery. Pre-operative hepatokines plasma levels were not significantly different in rats submitted to IT or SHAM protocol. Three months after the procedures the plasma levels of RBP4, aHSG, FGF21, and CRP were significantly lower in IT-operated animals when compared to SHAM-operated group. Three and 12 weeks after the IT and SHAM surgery, the AUCOGTT were significantly lower than AUCOGTT before the surgery. HOMA-IR was lower in rats after IT surgery in comparison to the SHAM-operated rats. Muscle and liver total lipids concentration was reduced after the IT procedure when compared to pre-IT conditions. IT had a significant reductive impact on the body weight in comparison to SHAM surgery in the 4th, 6th, 8th, and 10th week after the surgery. We conclude that IT reduces hepatokines’ plasma concentrations, muscle and liver total lipids concentration but not the inflammatory processes in the liver of Zucker (Crl:ZUC(ORL)-Leprfa) rats.

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Temporal effects of laparoscopic sleeve gastrectomy on adipokines, inflammation, and oxidative stress in patients with impaired glucose homeostasis

Cited by 11 publications

References 38 publications

Temporal Effects of Bariatric Surgery on Adipokines, Inflammation and Oxidative Stress in Subjects with Impaired Glucose Homeostasis at 4 Years of Follow-up

Temporal Effects of Bariatric Surgery on Adipokines, Inflammation and Oxidative Stress in Subjects with Impaired Glucose Homeostasis at 4 Years of Follow-up

Sleeve gastrectomy decreases high-fat diet induced colonic pro-inflammatory status through the gut microbiota alterations

Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats

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