Temporal expression of interleukin‐22, interleukin‐22 receptor 1 and interleukin‐22‐binding protein during experimental periodontitis in rats

Abstract

This study shows the expression and localization of IL-22, IL-22R1 and IL-22BP, as well as the relevant histopathological alterations during the development of experimental periodontitis.

IL‐22–expressing CD4+AhR+ T lymphocytes are associated with RANKL‐mediated alveolar bone resorption during experimental periodontitis

“…Pathologically, Th22 lymphocytes have been implicated in the immunopathogenesis of several inflammatory and autoimmune diseases . During experimental periodontitis, abundant IL‐22 + cells were observed in periodontal lesions . Similarly, a greater number of CD4 + IL‐22 + AhR + T lymphocytes was detected in periodontal tissues obtained from periodontitis patients compared with healthy individuals .…”

“…Using an animal model of periodontitis, IL‐22 + cells were clearly observed both in the gingival epithelium and in the nearby lamina propria in experimental periodontal lesions, and when human T lymphocytes were stimulated in vitro with Aggregatibacter actinomycetemcomitans , these cells showed higher expression levels of IL‐22 and AhR than non‐stimulated cells . In this context, a greater number of CD4 + IL‐22 + AhR + T lymphocytes was detected in periodontal tissues obtained from periodontitis patients compared with healthy individuals .…”

“…21 Conversely, in gingival crevicular fluid samples obtained from patients with periodontitis, higher levels of IL-22 were found, compared with samples obtained from both patients with gingivitis and healthy individuals, and these increased levels of IL-22 positively correlated with the overexpressed detection of AhR and loss of clinical attachment level of sampled periodontal pockets. 22 Using an animal model of periodontitis, IL-22 + cells were clearly observed both in the gingival epithelium and in the nearby lamina propria in experimental periodontal lesions, 23 and when human T lymphocytes were stimulated in vitro with Aggregatibacter actinomycetemcomitans, these cells showed higher expression levels of and AhR than non-stimulated cells. 24 In this context, a greater number of CD4 + IL-22 + AhR + T lymphocytes was detected in periodontal tissues obtained from periodontitis patients compared with healthy individuals.…”

The relationship between T‐helper cell polarization and the RANKL/OPG ratio in gingival tissues from chronic periodontitis patients

“…Periodontitis, caused by altered host-biofilm interactions in the gingival crevice, is the most common infectious disease and leads to progressive alveolar bone destruction and eventual tooth loss in humans (Barbato et al, 2015;Papapanou & Susin, 2017). Therefore, periodontal bone resorption is closely linked to the host immune response to a microbial challenge (Díaz-Zúñiga et al, 2017;Ghighi et al, 2018;Hienz, Paliwal, & Ivanovski, 2015;Pan et al, 2018;Takayanagi, 2005). During such pathological cascades, many immune cells polarize toward proinflammatory responses; for example, we previously reported increased levels of M1 phenotypes of macrophages in inflammatory gingival tissues .…”

Identification of hub genes and immune cell infiltration characteristics in chronic rhinosinusitis with nasal polyps: Bioinformatics analysis and experimental validation

“…CRSwNP (Pan et al, 2018;Khalmuratova et al, 2020). Only one study has shown that CRSwNP can impair the olfactorial signaling pathway and neuroactive ligand receptor pathway by affecting the expression of "olfactorial receptor activity" and "channel activity" genes (Xiong et al, 2020).…”