Temporal hemodynamic changes in a female mouse model of systemic lupus erythematosus

Dent, Elena; Taylor, Erin B.; Sasser, Jennifer M.; Ryan, Michael J.

doi:10.1152/ajprenal.00598.2019

Cited by 7 publications

(6 citation statements)

References 72 publications

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“…While there are limited data on the renal effects of leptin antagonism, a very recent study in pigs showed that antagonism of leptin prevents inflammation in a porcine model of ischemia reperfusion [ 91 ]. As we have previously published, the rates of albuminuria vary in this model of SLE [ 37 , 39 , 92 ], and treatment with LA did not improve albumin excretion despite improving glomerular injury ( Figure 5 ).…”

Section: Discussionsupporting

confidence: 56%

Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease

Kalusche,

Case,

Taylor

2023

Clinical Science

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that is characterized by B- and T-lymphocyte dysfunction and altered cytokine production, including elevated levels of the adipocytokine leptin. Leptin has various immunomodulatory properties, including promoting the expansion of proinflammatory T lymphocytes and the proliferation and survival of B cells. In the present study, we hypothesized that leptin antagonism would improve B- and T-cell dysfunction and attenuate hypertension in an experimental model of SLE, the NZBWF1 mouse. To test this hypothesis, 28-week-old female control and SLE mice were administered 5 mg/kg of murine leptin superantagonist (LA) or vehicle via ip injection every other day for four weeks. Analysis of peripheral blood immune cell populations showed no changes in total CD45R+ B and CD3+ T cell percentages after treatment with LA. However, SLE mice treated with LA had an improved CD4/CD8 ratio and decreased CD3+CD4−CD8− double negative (DN) T cells. Blood pressure was higher in SLE than in control, and treatment with LA decreased blood pressure in SLE mice. Treatment with LA also delayed the onset of albuminuria and decreased glomerulosclerosis in SLE mice. Renal immune cell infiltration was significantly higher in SLE mice as compared with control, but LA treatment was associated with decreased levels of renal CD4+ T cells. In conclusion, these data suggest that leptin plays a pathogenic role in the development of hypertension in SLE, in part, by promoting the expansion of inflammatory DN T cells and the infiltration of T cells into the kidneys.

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Section: Discussionsupporting

confidence: 56%

Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease

Kalusche,

Case,

Taylor

2023

Clinical Science

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“…Total lymphoid irradiation has been reported to prolong the survival, reduce proteinuria, and decrease anti-DNA antibody levels in NZBWF1 [ 17 , 47 , 48 ] and MRL/1 mice [ 18 ], but the mechanisms underlying these effects remain to be clarified. These reports implicated that the immune system was concerned with the alleviation of SLE-like morbidities.…”

Section: Discussionmentioning

confidence: 99%

Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells

Fujita,

Kuwabara,

Wang

et al. 2023

Journal of Immunology Research

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that can induce systemic inflammation. Ultraviolet-A and X-ray irradiation have been reported to have therapeutic effects in patients with SLE. We previously demonstrated that CD180-negative cells, these are radiosensitive, contribute to the development of SLE-like morbidity in NZBWF1 mice. In this study, the effects of irradiation on SLE-like morbidity manifestations in NZBWF1 mice and on CD180-negative cells were investigated. Whole-body irradiation, excluding the head, attenuated SLE-like morbidity in vivo, as indicated by the prevention of the renal lesion development, inhibition of anti-dsDNA antibody production, reduction of urinary protein levels, and prolongation of the lifespan. Irradiation also reduced the proportion of CD180-negative cells in the spleen. Although other immune cells or molecules may be triggered because of the whole-body irradiation treatment, previous research, and the current results suggest a strong relationship between the radiation-induced decrease in CD180-negative cells and the amelioration of SLE-like morbidities. Clinical trials assessing CD180-negative cells as a therapeutic target for SLE have been hampered by the lack of validated cell markers; nonetheless, the present findings suggest that radiotherapy may be a new therapeutic strategy for managing SLE symptoms.

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“…Jennifer Sasser (University of Mississippi Medical Center) is recognized as an expert in the renal adaptions to pregnancy (14,51). Her group has characterized the Dahl salt-sensitive rat as a model of preeclampsia that closely mimics the human disease.…”

Section: Promoting Diversity and Inclusionmentioning

confidence: 99%

AJP-Regulatory, Integrative and Comparative Physiology: Looking Toward the Future

Yosten¹

2020

American Journal of Physiology-Regulatory, Integrative and Comp

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The American Physiological Society has been my home society for over a decade, since I first joined as a graduate student in 2007. The Society has offered me many opportunities for personal and professional development, and thus I am very excited to contribute to one of the most important services of the Society: the dissemination of the ideas and research findings of the physiology community. For the last seven years, outgoing Editor-in-Chief, Willis K. " Rick" Samson (16,19,36,37,56) and his editorial team have demonstrated exemplary stewardship of the American Journal of Physiology-Regulatory, Integrative, and Comparative Physiology (AJP-RIC). As a testament to their success, Dr. Samson and his team have achieved an editorial board composition of 35% women, which is high compared with many APS and non-APS journals. Dr. Samson also employed AJP-RIC as a tool to promote the careers of early career investigators by adding the New Investigator Award review competition, in which review articles were solicited from early-stage investigators (34,35,38,41,48). Thus, Dr. Samson has established an important tradition of the Journal-promotion of women and early career physiologists. Likewise, under the leadership of Dr. Samson and his predecessor Dr. Curt Sigmund (39, 40), AJP-RIC has become known for facilitating rapid and high-quality peer review and publishing manuscripts that stand the test of time. This is most evident when considering the metric of citation half-life, which is currently 10.8 for AJP-RIC. This is an impressive metric, especially when compared with the lower citation half-lives of larger journals, such as Cell Metabolism (5.5), Nature Neuroscience (7.7), and Science (0.0). Clearly the AJP-RIC remains fundamentally strong, and I hope to maintain this tradition of excellence established by my predecessors as I assume the reins of Editor-in-Chief.

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Temporal hemodynamic changes in a female mouse model of systemic lupus erythematosus

Cited by 7 publications

References 72 publications

Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease

Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease

Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells

AJP-Regulatory, Integrative and Comparative Physiology: Looking Toward the Future

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