Temporal order memory differences in Alzheimer's disease and vascular dementia

Hampstead, Benjamin M.; Libon, David J.; Moelter, Stephen T.; Swirsky-Sacchetti, Thomas; Scheffer, Ludo; Platek, Steven M.; Chute, Douglas L.

doi:10.1080/13803390903418918

Cited by 20 publications

(12 citation statements)

References 59 publications

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“…Many patients with MCI also demonstrate disease pathology within the prefrontal cortex (Ewers et al, 2011). Consistent with the pathological processes in these key brain regions, temporal order memory deficits have been reported in patients with AD (Hampstead et al, 2010; Hanseeuw et al, 2011, Johnson and Kesner, 1997; Madsen and Kesner, 1995) and MCI (Bellassen et al, 2012). In fact, this latter study suggested that temporal order memory is a sensitive marker for subsequent conversion to AD (Bellassen et al, 2012).…”

Section: Introductionsupporting

confidence: 64%

“…We previously reported a linear relationship between span length and temporal order memory in patients with AD (Hampstead et al, 2010) while another study revealed a significant relationship between span and medial temporal lobe volume in MCI patients (Wenger et al, 2010). Therefore, we performed exploratory analyses to examine whether span length affected performance on the TST as a function of age and MCI.…”

Section: Introductionmentioning

confidence: 95%

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Impaired retention is responsible for temporal order memory deficits in mild cognitive impairment

et al. 2013

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Temporal order memory, or remembering the order of events, is critical for everyday functioning and is difficult for patients with mild cognitive impairment (MCI). It is currently unclear whether these patients have difficulty acquiring and/or retaining such information and whether deficits in these patients are in excess of “normal” age-related declines. Therefore, the current study examined age and disease-related changes in temporal order memory as well as whether memory load played a role in such changes. Young controls (n=25), older controls (n=34), and MCI patients (n=32) completed an experimental task that required the reconstruction of sequences that were 3, 4, or 5-items in length both immediately after presentation (i.e., immediate recall) and again following a 10-minute delay (i.e., delayed recall). During the immediate recall phase, there was an effect of age largely due to reduced performance at the two longest span lengths. Older controls and MCI patients only differed during the 5 span (controls > MCI). During the delayed recall, however, there were significant effects of both age and MCI regardless of span length. In MCI patients, immediate recall was significantly correlated with measures of executive functioning while delayed recall performance was only related to other memory tests. These findings suggest that MCI patients experience initial temporal order memory deficits at the point when information begins to exceed working memory capacity and become dependent on medial temporal lobe functioning. Longer-term deficits are due to an inability to retain information, consistent with the characteristic medial temporal lobe dysfunction in MCI.

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Section: Introductionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 95%

Impaired retention is responsible for temporal order memory deficits in mild cognitive impairment

et al. 2013

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“…To evaluate this attribute of memory, simple sequence learning tasks can be used (Devito and Eichenbaum, 2011; Kesner and Hunsaker, 2010), tasks evaluating recency judgments (Eichenbaum and Fortin, 2009), or tasks evaluating discrimination of duration information (Chiba et al , 2002; Jackson et al , 1998). Processes such as these have been shown to be impaired in a number of genetic disorders but has not been widely applied in research into mouse models of these disorders (Allman et al , 2011; Hampstead et al , 2010; Johnson and Kesner, 1997; Pirogovsky et al , 2009; Schwartz et al , 1991; Shipley et al , 2002; Vriezen and Moscovitch 1990). …”

Section: Behavioral Phenotyping Strategiesmentioning

confidence: 99%

Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders

Hunsaker

2012

Progress in Neurobiology

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There is a need for refinement of the current behavioral phenotyping methods for mouse models of genetic disorders. The current approach is to perform a behavioral screen using standardized tasks to define a broad phenotype of the model. This phenotype is then compared to what is known concerning the disorder being modeled. The weakness inherent in this approach is twofold: First, the tasks that make up these standard behavioral screens do not model specific behaviors associated with a given genetic mutation but rather phenotypes affected in various genetic disorders; secondly, these behavioral tasks are insufficiently sensitive to identify subtle phenotypes. An alternate phenotyping strategy is to determine the core behavioral phenotypes of the genetic disorder being studied and develop behavioral tasks to evaluate specific hypotheses concerning the behavioral consequences of the genetic mutation. This approach emphasizes direct comparisons between the mouse and human that facilitate the development of neurobehavioral biomarkers or quantitative outcome measures for studies of genetic disorders across species.

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“…Klekociuk and Summers [38] found lower digit backward test performance in their sample of mixed MCI compared to aMCI patients. Hampstead et al [39] assessed serial order using a letter span task and found that vascular dementia patients associated with subcortical white matter alterations (i.e., leukoaraiosis) produced more dysexecutive errors compared to patients with AD suggesting greater working memory deficits in vascular dementia as compared to AD.…”

Section: Discussionmentioning

confidence: 99%

Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall

Emrani

Libon

Lamar

et al. 2018

JAD

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Background Working memory (WM) is often assessed with serial order tests such as repeating digits backward. In prior dementia research using the Backward Digit Span Test (BDT), only aggregate test performance was examined. Objective The current research tallied primacy/recency effects, out-of-sequence transposition errors, perseverations, and omissions to assess WM deficits in patients with mild cognitive impairment (MCI). Methods Memory clinic patients (n = 66) were classified into three groups: single domain amnestic MCI (aMCI), combined mixed domain/dysexecutive MCI (mixed/dys MCI), and non-MCI where patients did not meet criteria for MCI. Serial order/WM ability was assessed by asking participants to repeat 7 trials of five digits backwards. Serial order position accuracy, transposition errors, perseverations, and omission errors were tallied. Results A 3 (group) × 5 (serial position) repeated measures ANOVA yielded a significant group × trial interaction. Follow-up analyses found attenuation of the recency effect for mixed/dys MCI patients. Mixed/dys MCI patients scored lower than non-MCI patients for serial position 3 (p < 0.003) serial position 4 (p < 0.002); and lower than both group for serial position 5 (recency; p < 0.002). Mixed/dys MCI patients also produced more transposition errors than both groups (p < 0.010); and more omissions (p < 0.020), and perseverations errors (p < 0.018) than non-MCI patients. Conclusions The attenuation of a recency effect using serial order parameters obtained from the BDT may provide a useful operational definition as well as additional diagnostic information regarding working memory deficits in MCI.

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Temporal order memory differences in Alzheimer's disease and vascular dementia

Cited by 20 publications

References 59 publications

Impaired retention is responsible for temporal order memory deficits in mild cognitive impairment

Impaired retention is responsible for temporal order memory deficits in mild cognitive impairment

Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders

Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall

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