Temporal osteoclastoma: an exceptional lesion in infancy

Abstract

Osteoclastoma is a rare skeletal lesion, characterized by large multinucleated giant osteoclastic cells; this lesion usually affects young adults with a prevalence of 1 case/1 million population. We report the case of a 9-year-old girl with a right temporal tumescence: X-ray, CT and MRI revealed the presence of a right temporal hyperostotic ring-like area over the lambdoid suture, with irregular margins and calcareous deposits. The tumour was expanding mainly toward the endocranium involving both cranial tables and diploë, without infiltrating the brain parenchyma. The child underwent complete microsurgical removal of the lesion. Histopathological findings revealed the giant cell tumour osteoclastoma. Correct modern preoperative neuroimaging workup, coupled with microneurosurgical technique, allowed successful lesion removal with good outcome. A review of the more recent literature and of mechanisms of pathology together with neuroradiological protocol and results of treatment are discussed.

Giant Cell Reparative Granuloma of the Temporal Bone: Neuroradiological and Immunohistochemical Findings. Case Report.

“…1,5,17,22,24,34,37,41) Multinucleated giant cells of extracranial GCT and GCRG are immunohistochemically positive for CD68, 2,3,13,16,18,20,21,28,31,32,40,42) suggesting histiocytic differentiation. Similar findings are reported for GCT 7,15) and GCRG 26) of the skull. Our case also indicates that almost all giant cells and GCRG of the Temporal Bone some of the mononuclear stromal cells show histiocytic differentiation.…”

Multicentric giant cell tumor in adolescents

“…Although rare, cranial GCTs occur most frequently in the endochondral bone of the middle fossa floor [14], with a specific tendency to occur in the sphenoid and temporal bones [15]. GCTs of the skull typically present in the third and fourth decades of life [16,17], with a slightly higher predominance in women and a high rate of recurrence (40-60%) [18]. These tumors are exceptionally rare in individuals younger than 20 years of age [19].…”

Giant cell tumor of the occipital bone: A case report and review of the literature

“…In total, <1% of GCTs are found in the cranial bones, and typically, GCTs are observed in adults aged between 20 and 40 years (11). In an analysis across a series of GCT patients, cranial bone involvement was identified in only 24 out of 2,404 cases, the majority of which was observed in the sphenoid and temporal bones (1,7,12).…”