Temporal processing dysfunction in schizophrenia as measured by time interval discrimination and tempo reproduction tasks

Papageorgiou, Charalabos; Karanasiou, Irene S.; Kapsali, Fotini; Stachtea, Xanthi; Kyprianou, Miltiades; Tsianaka, Eleni I; Karakatsanis, Nicolas A.; Rabavilas, Andreas D.; Uzunoglu, N.K.; Papadimitriou, George N.

doi:10.1016/j.pnpbp.2012.07.017

Cited by 30 publications

(30 citation statements)

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“…Note however, that differences in delay duration used in human (hypothetical seconds to months) vs. animal (seconds to minutes) delay discounting tasks may limit cross-species translational validity of such testing (McClure et al, 2007;Schultz, 2010). Nevertheless, another important aspect of such decision-making paradigms concerns temporal perception (Wittmann et al, 2007), in that the ability to perceive time is often altered in patients with schizophrenia, bipolar disorder, and other conditions (McDowell et al, 1996;Dale et al, 2010;Papageorgiou et al, 2013) and can be affected by treatments such as amphetamine (Fowler et al, 2009). Such changes in temporal perception in patients should be taken into account in future studies investigating mechanistic changes underlying decision-making deficits.…”

Section: Other Methods For Assessing Flexible Decision-making Across mentioning

confidence: 99%

Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models

Orsini

Moorman

Young

et al. 2015

Neuroscience & Biobehavioral Reviews

133

110

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Over the past 20 years there has been a growing interest in the neural underpinnings of cost/benefit decision-making. Recent studies with animal models have made considerable advances in our understanding of how different prefrontal, striatal, limbic and monoaminergic circuits interact to promote efficient risk/reward decision-making, and how dysfunction in these circuits underlies aberrant decision-making observed in numerous psychiatric disorders. This review will highlight recent findings from studies exploring these questions using a variety of behavioral assays, as well as molecular, pharmacological, neurophysiological, and translational approaches. We begin with a discussion of how neural systems related to decision subcomponents may interact to generate more complex decisions involving risk and uncertainty. This is followed by an overview of interactions between prefrontal-amygdala-dopamine and habenular circuits in regulating choice between certain and uncertain rewards and how different modes of dopamine transmission may contribute to these processes. These data will be compared with results from other studies investigating the contribution of some of these systems to guiding decision-making related to rewards vs. punishment. Lastly, we provide a brief summary of impairments in risk-related decision-making associated with psychiatric disorders, highlighting recent translational studies in laboratory animals.

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Section: Other Methods For Assessing Flexible Decision-making Across mentioning

confidence: 99%

Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models

Orsini

Moorman

Young

et al. 2015

Neuroscience & Biobehavioral Reviews

133

110

View full text Add to dashboard Cite

show abstract

“…Integration dysfunctions during motion perception in psychosis have previously been suggested for both social (abstract) motion attributes (Kim et al, 2005;Kim et al, 2011) and physical parameters, e.g. time (Volz et al, 2001;Papageorgiou et al, 2013). Visual-spatial motion characteristics are processed by the visual system in the occipital lobe (Blakemore et al, 2001;Fonlupt, 2003;Badler et al, 2010) and further integrated by posterior (occipito-parietal) regions (Straube and Chatterjee, 2010;Straube et al, 2011;Blos et al, 2012).…”

Section: Disconnectivity In Patients: Dysfunctional Perceptual Organimentioning

confidence: 99%

Neural basis of altered physical and social causality judgements in schizophrenia

Wende

Nagels

Stratmann

et al. 2015

Schizophrenia Research

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“…Mientras agentes agonistas de la DA (cocaína y metanfetamina) producen un enlentecimiento del tiempo percibido, los antagonistas (e.g. haloperidol) generan un acortamiento del tiempo subjetivo (Papageorgiou et al, 2013).…”

Section: Estudios Electrofisiológicosunclassified

“…Diversos autores coinciden al observar una tendencia a la sobreestimación e infraproducción de duraciones temporales (Papageorgiou et al, 2013). Mientras estudios iniciales arrojan resultados contradictorios sobre la dirección del déficit (sobreestimación y subestimación), otros más recientes muestran mayor consistencia en sus resultados.…”

Section: Estudios Conductualesunclassified

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El procesamiento temporal en la esquizofrenia: Revisión

Alústiza

Pujol

Molero

et al. 2015

Schizophrenia Research: Cognition

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We review the main contributions of the cognitive neuroscience literature in the field of time processing in schizophrenia. First, we summarize the theoretical concepts and terminology related to time and time estimation as well as the characterization of this deficit in the illness. Secondly, we deeply review the neuroanatomical basis of this deficit and its interaction with other cognitive processes and clinical symptoms. Thirdly, we specifically zoom into the main finding of studies which have analyzed temporal discrimination through cognitive tasks performed during functional neuroimaging. Resumen: Esta revisión pretende mostrar al lector los principales hallazgos de la literatura neurocientífica y cognitiva sobre la temporalidad en la esquizofrenia. Realizaremos primero una breve introducción sobre aspectos teóricos y conceptuales para adentrarnos luego en la importancia de su alteración en este trastorno. Concretamente, las estructuras cerebrales subyacentes y la interacción que guarda con otras disfunciones cognitivas y síntomas psicopatológicos. Incluye diferentes estudios con un enfoque tanto conductual como neurocientífico, aunque especialmente se centra en las tareas de discriminación temporal en la escala de milisegundos y en los estudios que emplean técnicas de neuroimagen funcional. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). IntroducciónEl procesamiento temporal, relevante en la conducta y cognición humanas, interesa a disciplinas diversas como la Filosofía, la Medicina y la Psicología. En la literatura, destacan los estudios sobre su disfunción en personas con patología cerebral, inducciones farmacológicas/toxicológicas o trastornos psiquiátricos, como la esquizofrenia (Grondin, 2010).Desde comienzos del siglo pasado, observaciones fenomenológi-cas, clínicas y neurobiológicas señalan su alteración en este trastorno (Bonnot et al., 2011). Es considerada clave por algunos modelos sobre su patogénesis, como el de dismetría cognitiva (Andreasen, 1999). La investigación neuropsicológica sobre la temporalidad en la esquizofrenia facilita la comprensión de su alteración neurobiológica y cognitiva, así como el modo en que ésta contribuye a sus síntomas.Existen diversos términos y clasificaciones para definir esta función. Distinguen principalmente entre percepción temporal, referida a aspectos más pasivos como la percepción de intervalos; y temporalidad motora, que alude a la organización temporal de los actos motores o cognitivos (Neufang et al., 2008). Aproximaciones teóricasFrente a la más tradicional, que defiende la existencia de un mecanismo central o reloj interno, otras apuestan por una diferenciación según la información utilizada para la estimación temporal. Mientras los modelos cronobiológicos se basan en la información ambiental, los cognitivos consideran la contribución de procesos atencionales y mnésicos. Entre los segundos, destacan los denominados Oscilador Temporal Interno (Treisman, 1963) y Cronometraje Escalar (Gibbon...

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Temporal processing dysfunction in schizophrenia as measured by time interval discrimination and tempo reproduction tasks

Cited by 30 publications

References 30 publications

Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models

Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models

Neural basis of altered physical and social causality judgements in schizophrenia

El procesamiento temporal en la esquizofrenia: Revisión

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