Temporal Profiles of Symptom Scores After Palliative Radiotherapy for Bleeding Gastric Cancer With Adjustment for the Palliative Prognostic Index: An Exploratory Analysis of a Multicentre Prospective Observational Study (JROSG 17–3)

Kawamoto, T.; Saitô, Tetsuo; Kosugi, Takashi; Nakamura, Naoki; Wada, Hitoshi; Tonari, Ayako; Ogawa, Hirofumi; Mitsuhashi, Norio; Yamada, Kazunari; Takahashi, Tetsuya; Ito, Kei; Sekii, Shuhei; Araki, Norio; Nozaki, Miwako; Heianna, Joichi; Murotani, Kenta; Hirano, Yasuhiro; Satoh, Atai; Onoe, Tsuyoshi; Shikama, Naoto

doi:10.1016/j.clon.2022.05.009

Cited by 3 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All but one of the published studies regarding the use of radiation therapy for the management of bleeding secondary to AGC was a retrospective case series or case-control study, with only one non-randomized clinical trial intervention studied (16)(17)(18)(19)(20)(21)(22)(24)(25)(26)(28)(29)(30)(31)39). The most common treatment regimen was 30 Gy in 10 fractions ranging from a single 8 Gy fraction dose to 42 Gy over 20 fractions.…”

Section: Radiationmentioning

confidence: 99%

“…The range of response rates to the varying doses of radiation was 50-89.5%. In contrast, Kawamoto et al focused solely on symptoms as a primary outcome and demonstrated that shortness of breath, pain, and distress improved after radiotherapy (30). At least two studies reported on the use of repeat radiotherapy doses in an attempt to control rebleeding (19,31).…”

Section: Radiationmentioning

confidence: 99%

See 1 more Smart Citation

Palliative interventions for patients with advanced gastric cancer: a systematic review

Kopecky¹,

Monton²,

Rosman³

et al. 2022

Chin Clin Oncol

View full text Add to dashboard Cite

Background: Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death worldwide. Advanced gastric cancer (AGC) is associated with significant morbidity and mortality and is commonly accompanied by a variety of distressing symptoms. Current National Comprehensive Cancer Network (NCCN) guidelines recommend palliative treatment modalities for patients with AGC and the treatment of AGC patients should be influenced by palliative care principles. The objective of this systematic review was to explore the published literature on palliative interventions for patients with AGC.Methods: We performed a systematic literature search to identify English language studies that investigated interventions to improve or treat the symptoms caused by AGC using PubMed, Embase, and Cochrane Library databases from January 1, 2010 to August 18, 2022. Two independent reviewers performed title and abstract review, followed by full-text review and data abstraction. Overall study quality and risk of bias was assessed using published quality assessment tools.Results: We identified 10,364 studies and included 66 studies published between 2010 and 2022 for final review. Among the studies, quality of life (QoL) metrics were most commonly a secondary outcome.Twenty-three studies addressed the palliative management of bleeding with the use of radiation therapy, surgery, arterial embolization, chemotherapy, or endoscopic interventions. Twenty-two studies addressed the management of obstructive symptoms with endoscopic stenting or surgical interventions. Most of these studies were of moderate quality and included well characterized outcomes focused on symptom reduction.Five studies assessed palliative modalities to reduce the symptomatic burden of intraabdominal ascites; these studies were less well characterized, and on average low quality. Fifteen studies of mixed quality assessed QoL for patients with AGC, with only one study evaluating specialty palliative care consultation. No studies outlined the prevalence or practices of advanced care planning in this patient population. Conclusions: Patients with AGC undergo a variety of interventions aimed at palliating the symptoms associated with their diagnosis and improving their QoL. Future research on palliative interventions for patients with AGC should utilize qualitative methodologies to measure outcomes related to symptom management and QoL, further explore the patient experience of living with AGC, and delineate best practices for advanced care planning in this population.

show abstract

Section: Radiationmentioning

confidence: 99%

Section: Radiationmentioning

confidence: 99%

Palliative interventions for patients with advanced gastric cancer: a systematic review

Kopecky¹,

Monton²,

Rosman³

et al. 2022

Chin Clin Oncol

View full text Add to dashboard Cite

show abstract

“…This finding is supported by the following four reasons: First, the time-dependent ROC analysis indicated that the AUC decreased as the time progressed from 2 to 5 months, suggesting that PPI had a high predictive ability for short-term mortality. Second, our previous research found that only single-fraction radiotherapy resulted in significant improvements in fatigue and stress over two months, in contrast to multiple-fraction therapy [3] . Therefore, patients with expected survival of ≤ 2 months should receive single-fraction therapy.…”

Section: Discussionmentioning

confidence: 93%

“…The Japanese Radiation Oncology Study Group (JROSG) study 17–3 (UMIN-CTR: UMIN000029580), which is the first multicenter prospective study on palliative radiotherapy for gastric cancer, demonstrated a high bleeding response rate [2] . A secondary analysis of the JROSG 17–3 study investigating the temporal changes in symptom scores indicated that after radiotherapy, amelioration of dyspnea, pain, and stress was observed in all 55 patients after radiotherapy [3] . We found that while single-fraction radiotherapy resulted in a significant improvement in fatigue and stress over 2 months, multiple-fraction radiotherapy did not [3] .…”

Section: Introductionmentioning

confidence: 99%

“…A secondary analysis of the JROSG 17–3 study investigating the temporal changes in symptom scores indicated that after radiotherapy, amelioration of dyspnea, pain, and stress was observed in all 55 patients after radiotherapy [3] . We found that while single-fraction radiotherapy resulted in a significant improvement in fatigue and stress over 2 months, multiple-fraction radiotherapy did not [3] . Multiple-fraction radiotherapy may have hampered the improvement in fatigue and distress owing to its toxicity or treatment burden; single-fraction radiotherapy should be a reasonable choice for patients with expected survival of ≤ 2 months.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation