For profit maximization, the model-based stock price prediction can give valuable guidance to the investors. However, due to the existence of the high noise in financial data, it is inevitable that the deep neural networks trained by the original data fail to accurately predict the stock price. To address the problem, the wavelet threshold-denoising method, which has been widely applied in signal denoising, is adopted to preprocess the training data. The data preprocessing with the soft/hard threshold method can obviously restrain noise, and a new multioptimal combination wavelet transform (MOCWT) method is proposed. In this method, a novel threshold-denoising function is presented to reduce the degree of distortion in signal reconstruction. The experimental results clearly showed that the proposed MOCWT outperforms the traditional methods in the term of prediction accuracy.