Temporal stability of chemical hormesis (CH): Is CH just a temporary stop on the road to thresholds and toxic responses?

Mushak, Paul

doi:10.1016/j.scitotenv.2016.06.233

Cited by 12 publications

(4 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hormesis usually presents as low-dose stimulation and high-dose inhibition19. Temporal features also play important roles because many studies show that the hormetic dose-response relationship can occur after an initial disruption in homeostasis2021. Mechanistically, the disruption triggers an overcompensation response, which results in a hormetic effect at the late stage20.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm−/− mouse embryonic fibroblasts

Sun

Wei

Fei

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Radiofrequency electromagnetic fields (RF-EMFs) have been classified by the International Agency for Research on Cancer as possible carcinogens to humans; however, this conclusion is based on limited epidemiological findings and lacks solid support from experimental studies. In particular, there are no consistent data regarding the genotoxicity of RF-EMFs. Ataxia telangiectasia mutated (ATM) is recognised as a chief guardian of genomic stability. To address the debate on whether RF-EMFs are genotoxic, we compared the effects of 1,800 MHz RF-EMF exposure on genomic DNA in mouse embryonic fibroblasts (MEFs) with proficient (Atm+/+) or deficient (Atm−/−) ATM. In Atm+/+ MEFs, RF-EMF exposure for 1 h at an average special absorption rate of 4.0 W/kg induced significant DNA single-strand breaks (SSBs) and activated the SSB repair mechanism. This effect reduced the DNA damage to less than that of the background level after 36 hours of exposure. In the Atm−/− MEFs, the same RF-EMF exposure for 12 h induced both SSBs and double-strand breaks and activated the two repair processes, which also reduced the DNA damage to less than the control level after prolonged exposure. The observed phenomenon is similar to the hormesis of a toxic substance at a low dose. To the best of our knowledge, this study is the first to report a hormesis-like effect of an RF-EMF.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Although AR is beneficial for biological systems exposed to RF-EMFs, the hormesis-like effect might have different consequences in these systems21. It is well accepted that a certain level of DNA damage is necessary for normal biological processes.…”

Section: Discussionmentioning

confidence: 99%

Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm−/− mouse embryonic fibroblasts

Sun

Wei

Fei

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Many studies show that stress induces the disruption in homeostasis [ 23 , 33 ] and as a consequence an overcompensation response is triggered to re-establish homeostasis. It needs gene expression and protein synthesis that progresses over time and leads to establish a new set-point for stress response systems.…”

Section: Molecular Stress Response To Elf-mfmentioning

confidence: 99%

Extremely Low-Frequency Magnetic Field as a Stress Factor—Really Detrimental?—Insight into Literature from the Last Decade

Klimek

Rogalska

2021

Brain Sciences

View full text Add to dashboard Cite

Biological effects of extremely low-frequency magnetic field (ELF-MF) and its consequences on human health have become the subject of important and recurrent public debate. ELF-MF evokes cell/organism responses that are characteristic to a general stress reaction, thus it can be regarded as a stress factor. Exposure to ELF-MF “turns on” different intracellular mechanisms into both directions: compensatory or deleterious ones. ELF-MF can provoke morphological and physiological changes in stress-related systems, mainly nervous, hormonal, and immunological ones. This review summarizes the ELF-MF-mediated changes at various levels of the organism organization. Special attention is placed on the review of literature from the last decade. Most studies on ELF-MF effects concentrate on its negative influence, e.g., impairment of behavior towards depressive and anxiety disorders; however, in the last decade there was an increase in the number of research studies showing stimulating impact of ELF-MF on neuroplasticity and neurorehabilitation. In the face of numerous studies on the ELF-MF action, it is necessary to systematize the knowledge for a better understanding of the phenomenon, in order to reduce the risk associated with the exposure to this factor and to recognize the possibility of using it as a therapeutic agent.

show abstract

“…In some cases, high doses of chemical or environmental factors are detrimental to biological systems, whereas low doses induce endogenous survival systems, a phenomenon known as hormesis [30][31][32]. The hormetic dose-response relationship can occur after an initial homoeostasis disruption, which must then be re-established.…”

Section: Introductionmentioning

confidence: 99%

New View on the Impact of the Low-Frequency Electromagnetic Field (50 Hz) on Stress Responses: Hormesis Effect

et al. 2022

View full text Add to dashboard Cite

Introduction: Low-frequency electromagnetic field (50 Hz) (EMF) can modify crucial neuronal processes. Existing data indicate that exposure to EMF may represent a mild stressor and contribute to disturbances of hypothalamic-pituitary-adrenal (HPA) axis. The important regulatory pathways controlling HPA axis activity include two types of corticosteroid receptors: mineralocorticoid (MR) and glucocorticoid (GR) receptors. There are particularly abundant in the hippocampus, a key locus of HPA axis feedback control. The research aimed at determining whether 1) EMF exhibits hormesis, it means bidirectional action depending on EMF intensity (1 or 7 mT), and 2) repeated EMF exposure changes stress response to subsequent stress factors. Methods: The exposure (7-day, 1h/day) of adult rats to EMF (1 mT and 7 mT) was repeated 3 times. HPA axis hormones and their receptors were analysed after each following exposure. Moreover, the impact of EMF exposure on hormonal and behavioural responses to subsequent stress factor - open-field test was evaluated. Results/Discussion: Our data suggest that exposure to EMF can establish a new “set-point” for HPA axis activity. The direction and dynamics of this process depend on the intensity of EMF and the number of exposures. EMF of 1 mT induced an adaptive stress response, but 7 mT EMF caused sensitization. Consequently, EMF changed the vulnerability of the organism to a subsequent stress factor. We have also shown the increase of MR mRNA abundance in hippocampus of 1 mT EMF exposed rats, which can represent the possible neuroprotective response and suggest therapeutic properties of electromagnetic fields.

show abstract

Temporal stability of chemical hormesis (CH): Is CH just a temporary stop on the road to thresholds and toxic responses?

Cited by 12 publications

References 52 publications

Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm−/− mouse embryonic fibroblasts

Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm−/− mouse embryonic fibroblasts

Extremely Low-Frequency Magnetic Field as a Stress Factor—Really Detrimental?—Insight into Literature from the Last Decade

New View on the Impact of the Low-Frequency Electromagnetic Field (50 Hz) on Stress Responses: Hormesis Effect

Contact Info

Product

Resources

About