Temporal Trends and Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement for Bicuspid Aortic Valve Stenosis

Elbadawi, Ayman; Saad, Marwan; Elgendy, Islam Y.; Barssoum, Kirolos; Omer, Mohamed; Soliman, Ahmed M.; Almahmoud, Mohamed Faher; Ogunbayo, Gbolahan; Mentias, Amgad; Gilani, Syed Amir; Jneid, Hani; Aronow, Herbert D.; Kleiman, Neil; Abbott, J. Dawn

doi:10.1016/j.jcin.2019.06.037

Cited by 76 publications

(53 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Temporal trends and outcomes of transcatheter versus surgical aortic valve replacement in BAV revealed similar results on complications and outcomes [39]. However, several approaches over standard biological or mechanical valve replacement demonstrated new possible treatment strategies.…”

Section: Treatment Optionsmentioning

confidence: 86%

Current and Future Aspects of Multimodal Imaging, Diagnostic, and Treatment Strategies in Bicuspid Aortic Valve and Associated Aortopathies

Afzal

Piayda

Maier

et al. 2020

JCM

View full text Add to dashboard Cite

Bicuspid aortic valve (BAV) is the most frequent congenital cardiac abnormality leading to premature aortic valve apparatus dysfunction and is often associated with aortopathy. Therefore, current guidelines recommend a surgical aortic valve replacement (SAVR), even if many patients are deemed inoperable owing to their comorbidities and require alternatives such as transcatheter aortic valve replacement (TAVR). However, BAV variations remain challenging for procedural success. Therefore, the latest development in different imaging modalities (echocardiography, multislice-computertomographie, cardiovascular magnetic resonance) allows in-depth analysis for preprocedural risk stratification, follow up, and patient selection. Furthermore, we shed light on the latest developments in pre- and periprocedural fusion imaging as well as on current and future treatment options.

show abstract

Section: Treatment Optionsmentioning

confidence: 86%

Current and Future Aspects of Multimodal Imaging, Diagnostic, and Treatment Strategies in Bicuspid Aortic Valve and Associated Aortopathies

Afzal

Piayda

Maier

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…For example, patients with severe aortic valvular stenosis undergoing transcatheter aortic valve intervention (TAVI) commonly suffer from atrioventricular (AV) nodal blockade intra- or periprocedurally in part as a result of mechanical impingement of the nearby AV node. 79 -81 Cardiovascular interventionalists and electrophysiologists often work in lockstep to treat affected patients, with the common goal of promoting safe cardiac conduction while preserving the integrity of the newly placed valve. Transcatheter aortic valve intervention is a relatively new but now commonly utilized, safe, and highly efficacious technique used to treat a very prevalent disorder with high associated morbidity.…”

Section: The Importance Of a Pertinent Clinical Question And Multidismentioning

confidence: 99%

Machine Learning in Cardiology—Ensuring Clinical Impact Lives Up to the Hype

Russak

Chaudhry

Freitas

et al. 2020

J Cardiovasc Pharmacol Ther

View full text Add to dashboard Cite

Despite substantial advances in the study, treatment, and prevention of cardiovascular disease, numerous challenges relating to optimally screening, diagnosing, and managing patients remain. Simultaneous improvements in computing power, data storage, and data analytics have led to the development of new techniques to address these challenges. One powerful tool to this end is machine learning (ML), which aims to algorithmically identify and represent structure within data. Machine learning’s ability to efficiently analyze large and highly complex data sets make it a desirable investigative approach in modern biomedical research. Despite this potential and enormous public and private sector investment, few prospective studies have demonstrated improved clinical outcomes from this technology. This is particularly true in cardiology, despite its emphasis on objective, data-driven results. This threatens to stifle ML’s growth and use in mainstream medicine. We outline the current state of ML in cardiology and outline methods through which impactful and sustainable ML research can occur. Following these steps can ensure ML reaches its potential as a transformative technology in medicine.

show abstract

Section: Anatomic Factors Favoring Savrmentioning

confidence: 99%

“…Studies directly comparing SAVR to TAVR in bicuspid AS are scant; however, one study from the National Inpatient Sample of nearly 2000 propensity-matched patients found no major difference in in-hospital mortality or stroke between TAVR and SAVR [ 20 ]. Interestingly, SAVR was associated with significantly lower mortality among patients under 65 years of age and significantly lower rates of PPM implantation [ 20 ]. A smaller study prospectively studying low-risk patients with bicuspid AS demonstrated low rates of in-hospital mortality and stroke with TAVR; however, longer-term follow-up with a larger patient population is needed [ 21 ].…”

Section: Anatomic Factors Favoring Savrmentioning

confidence: 99%

Expansion of TAVR into Low-Risk Patients and Who to Consider for SAVR

et al. 2020

View full text Add to dashboard Cite

Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of severe aortic stenosis (AS) over the last decade. The results of the Placement of Aortic Transcatheter Valves (PARTNER) 3 and Evolut Low Risk trials demonstrated the safety and efficacy of TAVR in low-surgical-risk patients and led to the approval of TAVR for use across the risk spectrum. Heart teams around the world will now be faced with evaluating a deluge of younger, healthier patients with severe AS. Prior to the PARTNER 3 and Evolut Low Risk studies, this heterogenous patient population would have undergone surgical aortic valve replacement (SAVR). It is unlikely that TAVR will completely supplant SAVR for the treatment of severe AS in patients with a low surgical risk, as SAVR has excellent short- and long-term outcomes and years of durability data. In this review, we outline the critical role that SAVR will continue to play in the treatment of severe AS in the post-PARTNER 3/Evolut Low Risk era.

show abstract

Temporal Trends and Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement for Bicuspid Aortic Valve Stenosis

Cited by 76 publications

References 26 publications

Current and Future Aspects of Multimodal Imaging, Diagnostic, and Treatment Strategies in Bicuspid Aortic Valve and Associated Aortopathies

Current and Future Aspects of Multimodal Imaging, Diagnostic, and Treatment Strategies in Bicuspid Aortic Valve and Associated Aortopathies

Machine Learning in Cardiology—Ensuring Clinical Impact Lives Up to the Hype

Expansion of TAVR into Low-Risk Patients and Who to Consider for SAVR

Contact Info

Product

Resources

About