Temporal Trends and Outcomes of Patients Undergoing Percutaneous Coronary Interventions for Cardiogenic Shock in the Setting of Acute Myocardial Infarction

Wayangankar, Siddharth A.; Bangalore, Sripal; McCoy, Lisa A.; Jneid, Hani; Latif, Faisal; Karrowni, Wassef; Charitakis, Konstantinos; Feldman, Dmitriy N.; Dakik, Habib A.; Mauri, Laura; Peterson, Eric D.; Messenger, John C.; Roe, M.T.; Mukherjee, Debabrata; Klein, Andrew J.

doi:10.1016/j.jcin.2015.10.039

Cited by 222 publications

(142 citation statements)

References 24 publications

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“…Mortality in AMI patients with cardiogenic shock remains very high, even in the current interventional era for AMI. 28 In the present study, in-hospital mortality in the Killip class 4 group reached 34.0%, and AKI commonly developed in this subgroup of patients (prevalence, 31.3%) and was closely linked to adverse outcomes; nonetheless, the significant adverse effects of AKI on in-hospital outcome were not evident after multivariate adjustment. Although the reason why AKI did not predict adverse outcome in the Killip class 4 group remains unclear, several factors may account for the results.…”

Section: Predictors Of In-hospital Outcomecontrasting

confidence: 43%

Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction　― Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy ―

Kuji

Kosuge

Kimura

et al. 2017

Circ J

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Section: Predictors Of In-hospital Outcomecontrasting

confidence: 43%

Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction　― Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy ―

Kuji

Kosuge

Kimura

et al. 2017

Circ J

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“…However, a recent report from the National Cardiovascular Database Registry Cath‐PCI registry, which included more than 56 000 patients with CS complicating AMI who underwent a PCI within 24 hours from acute symptom onset, showed that the hospital death rate for this patient group increased between 2005–2006 (27.6%) and 2011–2013 (30.6%) 36. This finding highlights the importance of additional research into the use of various therapeutic approaches to improve the short‐term outcomes for patients who develop CS.…”

Section: Discussionmentioning

confidence: 99%

Ten‐Year (2001–2011) Trends in the Incidence Rates and Short‐Term Outcomes of Early Versus Late Onset Cardiogenic Shock After Hospitalization for Acute Myocardial Infarction

Nguyen

Yarzebski

Lessard

et al. 2017

JAHA

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BackgroundCardiogenic shock (CS) is a serious complication of acute myocardial infarction, and the time of onset of CS has a potential role in influencing its prognosis. Limited contemporary data exist on this complication, however, especially from a population‐based perspective. Our study objectives were to describe decade‐long trends in the incidence, in‐hospital mortality, and factors associated with the development of CS in 3 temporal contexts: (1) before hospital arrival for acute myocardial infarction (prehospital CS); (2) within 24 hours of hospitalization (early CS); and (3) ≥24 hours after hospitalization (late CS).Methods and ResultsThe study population consisted of 5782 patients with an acute myocardial infarction who were admitted to all 11 hospitals in central Massachusetts on a biennial basis between 2001 and 2011. The overall proportion of patients who developed CS was 5.2%. The proportion of patients with prehospital CS (1.6%) and late CS (1.5%) remained stable over time, whereas the proportion of patients with early CS declined from 2.2% in 2001–2003 to 1.2% in 2009–2011. In‐hospital mortality for prehospital CS increased from 38.9% in 2001–2003 to 53.6% in 2009–2011, whereas in‐hospital mortality for early and late CS decreased over time (35.9% and 64.7% in 2001–2003 to 15.8% and 39.1% in 2009–2011, respectively).ConclusionsDevelopment of prehospital and in‐hospital CS was associated with poor short‐term survival and the in‐hospital death rates among those with prehospital CS increased over time. Interventions focused on preventing or treating prehospital and late CS are needed to improve in‐hospital survival after acute myocardial infarction.

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“…56 Although 5% to 12% of ACS cases are complicated by CS, this presentation is often associated with a large degree of at-risk myocardium. 4,57 In patients with a recent ACS, mechanical complications (including papillary muscle rupture, ventricular septal defect, or free wall rupture) were historically thought to be late complications but most frequently present within 24 hours of hospitalization. 58,59 An index of suspicion and rapid echocardiography are required for such diagnoses.…”

Section: Pathogenesismentioning

confidence: 99%

“…4,57,[91][92][93] An analysis of the Nationwide Inpatient Sample Database between 2003 and 2010 reported an increase in the prevalence of CS from 6% to 10% in the overall population and from 7% to 12% among patients >75 years of age presenting with STEMI. 4 In-hospital mortality decreased from 45% to 34% over the same time frame, although mortality rates remained high (55%) in patients >75 years of age.…”

Section: Contemporary Outcomes Prognosis and Resource Use Trends Inmentioning

confidence: 99%

Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association

Diepen¹,

Katz²,

Albert³

et al. 2017

Circulation

1,349

1,165

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Cardiogenic shock is a high-acuity, potentially complex, and hemodynamically diverse state of end-organ hypoperfusion that is frequently associated with multisystem organ failure. Despite improving survival in recent years, patient morbidity and mortality remain high, and there are few evidence-based therapeutic interventions known to clearly improve patient outcomes. This scientific statement on cardiogenic shock summarizes the epidemiology, pathophysiology, causes, and outcomes of cardiogenic shock; reviews contemporary best medical, surgical, mechanical circulatory support, and palliative care practices; advocates for the development of regionalized systems of care; and outlines future research priorities. Cardiogenic shock (CS) is a low-cardiac-output state resulting in life-threatening end-organ hypoperfusion and hypoxia.1,2 Acute myocardial infarction (MI) with left ventricular (LV) dysfunction remains the most frequent cause of CS. 1,3 Advances in reperfusion therapy have been associated with improvements in survival, but significant regional disparities in evidence-based care have been reported, and in-hospital mortality remains high (27%-51%).1,4-9 Management recommendations are distributed between disease-specific statements and guidelines, and a dedicated and comprehensive clinical resource in this area is lacking. Thus, consolidating the evidence to define contemporary best medical and surgical CS practices for both MI-associated CS and other types of CS may be an important step in knowledge translation to help attenuate disparities in evidence-based care.Regional systems of care coupled with treatment algorithms have improved survival in high-acuity time-sensitive conditions such as MI, out-of-hospital cardiac arrest (OHCA), and trauma.10-12 Applying a similar framework to CS management may lead to similar improvements in survival, and CS systems of care are emerging within existing regional cardiovascular emergency care networks; however, guidance from a national expert group on structure and systems of care has not been available. 13,14 Accordingly, the purposes of this American Heart Association (AHA) scientific statement on CS are to summarize our contemporary understanding of the epidemiology, pathophysiology, and in-hospital best care practices into a single clinical resource document; to suggest a stepwise management algorithm that integrates medical, surgical, and mechanical circulatory support (MCS) therapies; and to propose a Mission: Lifelinesupported pathway for the development of integrated regionalized CS systems of care. DEFINITION OF CSAcute cardiac hemodynamic instability may result from disorders that impair function of the myocardium, valves, conduction system, or pericardium, either in isolation HISTORICAL PERSPECTIVESBefore the routine use of early revascularization, MIassociated CS had an in-hospital mortality exceeding 80%. A registry trial of 250 patients with acute MI described the association between bedside physical examination (Killip classification) for the as...

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Temporal Trends and Outcomes of Patients Undergoing Percutaneous Coronary Interventions for Cardiogenic Shock in the Setting of Acute Myocardial Infarction

Cited by 222 publications

References 24 publications

Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction　― Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy ―

Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction　― Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy ―

Ten‐Year (2001–2011) Trends in the Incidence Rates and Short‐Term Outcomes of Early Versus Late Onset Cardiogenic Shock After Hospitalization for Acute Myocardial Infarction

Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association

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Temporal Trends and Outcomes of Patients Undergoing Percutaneous Coronary Interventions for Cardiogenic Shock in the Setting of Acute Myocardial Infarction

Cited by 222 publications

References 24 publications

Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction ― Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy ―

Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction ― Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy ―

Ten‐Year (2001–2011) Trends in the Incidence Rates and Short‐Term Outcomes of Early Versus Late Onset Cardiogenic Shock After Hospitalization for Acute Myocardial Infarction

Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association

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Product

Resources

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Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction　― Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy ―

Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction　― Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy ―