Temporal trends in hospitalization for rotavirus gastroenteritis: A nationwide study in Italy, 2005–2012

Mattei, Antonella; Sbarbati, M; Fiasca, Fabiana; Angelone, Anna Maria; M, Mazzei; Orio, Ferdinando di

doi:10.1080/21645515.2015.1081726

Cited by 17 publications

(18 citation statements)

References 22 publications

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“… 4 An analysis of hospital discharge data from 2005 to 2012 estimated the hospitalization rate for RVGE in children under 6 y old to be 146 and 150 per 100,000 children, as primary and secondary diagnosis, respectively. 2 In the Lombardy region, 50.8% of AGE hospitalizations were found to be due to rotavirus and a further 14% had a possible link to the virus. 5 Both studies found a peak in hospitalization among children under 2 y old.…”

Section: Introductionmentioning

confidence: 98%

“…Rotavirus vaccines, available since 2006, have been recommended for all children by the World Health Organization (WHO) since 2009 and have been successfully implemented, reducing RVGE incidence and costs, in several European countries and the USA in the last 10 y. 2,8 Recently, a natural experiment took place in Northern Ireland, which has implemented routine rotavirus vaccination, and the Republic of Ireland, with no rotavirus vaccination program. In Northern Ireland, 2 y after introducing vaccination, the incidence of rotavirus infection was reduced by 54% compared with the pre-vaccination era, AGE notifications in the highest risk group (< 2 y old) decreased by 53% and AGE hospitalizations decreased by 40% in children <5 y old.…”

Section: Introductionmentioning

confidence: 99%

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Parents' insights after pediatric hospitalization due to rotavirus gastroenteritis in Italy

Marchetti

Vetter

Conforti³

et al. 2017

Human Vaccines & Immunotherapeutics

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Most of the severe cases of acute gastroenteritis in infants and children under 5 globally are caused by rotavirus infection. There are nearly 15,000 rotavirus gastroenteritis (RVGE) hospitalizations in Italy each year, which could be reduced by available rotavirus vaccines. In addition to the economic and societal burden, RVGE hospitalization could impact families negatively. The aim of this survey was to obtain parents' insights after hospitalization of their child for RVGE. Parents, of 500 children aged 0–5 years, were interviewed about their experience of RVGE hospitalization and asked to rate their stress on different items and overall. Most children (32.6%) were hospitalized aged 12–23 months, and 6.8% were <6 months old. Family pediatricians referred 56.2% of cases to hospital, and 25.8% went based on their parents' decision. During hospitalization, mean parental stress scores (out of 10, with 10 as highest stress) ranged from 6.6 to 8.4. The highest scores were for child malaise (8.42, SD 1.00), vomiting/diarrhea (8.07, SD 0.97), stress for the family in general (7.82, SD 0.90), parental stress (7.68, SD 0.93) and child dehydration (7.18, SD 1.02). The overall stress for the family was graded as ‘high' by 67.2% of parents.Geographical areas and stress level were related (p = 0.0071), being the “high” stress score not an evenly distributed variable (p < 0.0001). Most children (91.8%) were not vaccinated against rotavirus, as most parents (74.5%) were not aware of vaccination availability. Parental distress due to RVGE hospitalization appears to be significant (93.6% reporting high/medium stress) and there is an important lack of awareness among parents about rotavirus vaccination. More education on RVGE for families in Italy should be warranted.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Parents' insights after pediatric hospitalization due to rotavirus gastroenteritis in Italy

Marchetti

Vetter

Conforti³

et al. 2017

Human Vaccines & Immunotherapeutics

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“…In Italy, RVGE has an estimated incidence of about 5/100 children <5 years [ 6 ], which was reported to result annually in 320,000 cases handled at home, 80,000 visits to the physician’s office, 10,000 hospitalizations, and 11 deaths [ 7 ]. A recent study found an average annual hospitalization rate for RVGE of 296/100,000 children <5 years, with 81% of cases in the <3 years age group [ 8 ]. The burden of disease is believed to be underestimated by up to 50% [ 8 , 9 , 10 , 11 ] and results in an economic impact of 144 million euros in health and social costs, as well as in overstretching and cluttering emergency departments (ED) and primary healthcare facilities [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Italian Physicians’ Opinions on Rotavirus Vaccine Implementation

et al. 2017

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Rotavirus (RV) infection is the main cause of severe acute gastroenteritis (GE) in the pediatric population and has a major impact in both developing and industrialized countries. The reduction of severe RVGE cases, followed by death or hospitalization, is considered the main benefit of RV vaccination, even though its implementation often faces obstacles. In Italy, the recently approved National Immunization Plan aims to overcome the differences among regions, offering a universal free RV vaccination. The aim of the study was to evaluate the opinions on benefit and acceptability of RV vaccination related to the perception of the burden of RV disease. Data were collected from 108 physicians in 2015 by a questionnaire consisting of 12 questions; some answers were compared with those obtained with a similar tool in 2011. The majority of respondents (76.2%) was convinced of the benefit of the vaccine and 57.4% recommended it routinely, but more than half indicated a <25% adherence to RV vaccination among their patients. As the main reasons of vaccine refusal, skepticism about the vaccine (60.4%) and its cost (34.1%) were indicated. Our data confirm that more information and counselling are needed to increase RV vaccine coverage.

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“…Limitations of the study. Using the hospital discharge database as informational flow, some diagnoses could be excluded [32,33,34].…”

Section: Discussionmentioning

confidence: 99%

Trends in Hospital Admissions for Pertussis Infection: A Nationwide Retrospective Observational Study in Italy, 2002–2016

Fiasca

Gabutti

Mattei

2019

IJERPH

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Background: Pertussis is a highly contagious infectious disease which continues to be an important public-health issue despite the high immunization coverage rates achieved. However, evidence of increased circulation of pertussis among adolescents and adults due to waning immunity and atypical clinical manifestations seem to be the main reasons for its resurgence. The aim of this study was the analysis of the epidemiological trend for pertussis-related hospitalizations in Italy, in relation with vaccination coverage and information from laboratory confirmed cases of pertussis. Methods: A retrospective observational study investigating hospitalizations for pertussis from 2002 to 2016 in Italy was conducted. Frequencies and rates of hospitalization were analyzed and hospitalization data were compared with a series of already published laboratory confirmed data. Results: This study highlighted a rising trend for pertussis hospitalizations in Italy since 2008. Infants aged <1 year showed the highest frequencies (63.39%) and average rates (74.60 × 100000 infants) of hospitalization despite an extremely high vaccination coverage (95.89%). An increasing trend of hospitalization frequency emerged for the age group with levels of IgG antibodies to pertussis toxin compatible with pertussis infection within the last year (20–29 years old age group). Conclusions: The rising trend for pertussis hospitalizations and the greater involvement of infants aged <1 year require an integrated approach, including the implementation of booster doses administration in adolescence and adulthood, the vaccination of pregnant women and the cocoon strategy.

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Temporal trends in hospitalization for rotavirus gastroenteritis: A nationwide study in Italy, 2005–2012

Cited by 17 publications

References 22 publications

Parents' insights after pediatric hospitalization due to rotavirus gastroenteritis in Italy

Parents' insights after pediatric hospitalization due to rotavirus gastroenteritis in Italy

Italian Physicians’ Opinions on Rotavirus Vaccine Implementation

Trends in Hospital Admissions for Pertussis Infection: A Nationwide Retrospective Observational Study in Italy, 2002–2016

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