Temporal trends in oropharyngeal cancer incidence, survival, and cancer-directed surgery among elderly Americans

Chidambaram, Smrithi; Hong, Scott A.; Simpson, Matthew C.; Osazuwa‐Peters, Nosayaba; Ward, Greg

doi:10.1016/j.oraloncology.2022.106132

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…For HPV-positive OPC very elderly patients, a shift towards non-surgical therapy, possibly due to the known favorable response of HPV-associated tumors to radiotherapy (RT) and/or poor surgical candidacy, has been reported in recent years, without a detrimental impact on survival. However, the best treatment modality has not yet been determined [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Interplay between Age and Viral Status in EBV-Related Nasopharyngeal and HPV-Related Oropharyngeal Carcinoma Patients

Cavalieri

Bossi

Infante

et al. 2022

Cancers

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Background. The aim of this work was to analyze the interplay between age and viral status on the outcomes in loco-regionally advanced oropharyngeal and nasopharyngeal cancer patients treated with radiotherapy and different chemotherapy combinations. Methods. A retrospective (2006–2017) analysis was performed on non-metastatic loco-regionally advanced oropharyngeal (both HPV+ and HPV−) and EBV+ nasopharyngeal cancer patients (young: <65 years vs. elderly: ≥65 years) treated with radiotherapy with or without chemotherapy. The impact of age and viral status on overall (OS) and disease-free survival (DFS) were studied with multivariable models, which were adjusted for smoking, stage, comorbidities, chemotherapy dose intensity and treatment strategy. Results. We analyzed 324 patients (146 HPV+ oropharynx, 63 HPV−, 115 nasopharynx). Elderly patients had more comorbidities, and received less intensive treatments when compared to younger subjects. Although OS and DFS were shorter in older patients, after adjustment for stage, smoking, comorbidities, treatment strategy and dose intensity, no significant differences in terms of survival were observed according to age (65 vs. 50 years of age: HR 1.89, 95% CI 0.45–7.84 for HPV+ OPC; HR 0.91, 95% CI 0.29–2.89 for HPV− OPC; HR 1.99, 95% CI 0.9–4.39 for NPC; p = 0.395). Conclusions. Several potential age-related (comorbidities, treatment intensity) and disease-related (stage) confounding factors play a prognostic role with differential impacts on both virus and non-virus-related tumors. In HPV+ oropharyngeal cancer and in EBV+ nasopharyngeal cancer patients, age should be considered as the expression of an array of host- and tumor-related features rather than an independent prognostic factor.

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Section: Introductionmentioning

confidence: 99%

The Interplay between Age and Viral Status in EBV-Related Nasopharyngeal and HPV-Related Oropharyngeal Carcinoma Patients

Cavalieri

Bossi

Infante

et al. 2022

Cancers

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The increasing prevalence of cancer in the elderly: An investigation of epidemiological trends

Prathap,

Kirubha,

Rajan

et al. 2024

Aging Medicine

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Cancer poses a significant health threat to the elderly, accounting for a substantial proportion of cancer patients aged 65 and above. As life expectancy continues to rise and the population ages, the incidence of cancer in the elderly is expected to increase further. Age is a major risk factor for the majority of common cancers, with the incidence and prevalence rising as individuals grow older. Factors such as chemoprevention and environmental carcinogen elimination may influence the process of carcinogenesis. Studies reveal that the incidence and mortality rates of various cancers in the elderly and extremely old individuals are on the rise worldwide, with most types peaking around the age of 75 to 90, followed by a sharp decline. Birth cohort and period effects also play a complex role in the connection between aging and cancer risk. Clinical trials often exclude older individuals, limiting our understanding of cancer treatments' effects on this particular age group. More research is needed to focus on the unique requirements of older adults with cancer.

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Epidemiology of Cancer in Older Adults: A Systematic Review

Pilleron,

Bastiaannet

2024

Curr Oncol Rep

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Temporal trends in oropharyngeal cancer incidence, survival, and cancer-directed surgery among elderly Americans

Cited by 3 publications

References 41 publications

The Interplay between Age and Viral Status in EBV-Related Nasopharyngeal and HPV-Related Oropharyngeal Carcinoma Patients

The Interplay between Age and Viral Status in EBV-Related Nasopharyngeal and HPV-Related Oropharyngeal Carcinoma Patients

The increasing prevalence of cancer in the elderly: An investigation of epidemiological trends

Epidemiology of Cancer in Older Adults: A Systematic Review

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