Temporal trends in the epidemiology of inflammatory bowel diseases in the public healthcare system in Brazil: A large population-based study

Quaresma, Abel Botelho; Damião, Adérson Omar Mourão Cintra; Coy, Cláudio Saddy Rodrigues; Magro, Daniéla Oliveira; Hino, Adriano Akira Ferreira; Valverde, Douglas Andreas; Panaccione, Remo; Coward, Stephanie; Ng, Siew C.; Kaplan, Gilaad G.; Kotze, Paulo Gustavo

doi:10.1016/j.lana.2022.100298

Cited by 17 publications

(29 citation statements)

References 27 publications

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“…The incidence and prevalence of CD in Brazil and other newly industrialised countries are still intermediate compared with those in industrialised countries, but they have increased in recent years. [16][17][18] In 2020, the incidence of CD in Brazil was 2.7/100 000, and the prevalence was 33.7/100 000. In Bahia state, where the study was performed, the incidence of CD was 1/100 000 and the prevalence was 22/100 000 in 2020.…”

Section: Discussionmentioning

confidence: 99%

“…In Bahia state, where the study was performed, the incidence of CD was 1/100 000 and the prevalence was 22/100 000 in 2020. 16 This increment has led to a greater interest in the study of clinical characteristics and course of CD in newly industrialised countries. [19][20][21] Our study showed equivalent results between sexes, similar to those of the previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Variables associated with progression of moderate-to-severe Crohn’s disease

Sacramento

Motta

Alves

et al. 2022

BMJ Open Gastroenterol

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ObjectiveDetermine the variables associated with hospitalisations in patients with Crohn’s disease and those associated with surgery, intestinal resection, hospital readmission, need for multiple operations and immunobiological agent use.DesignA cross-sectional study was conducted from 2019 to 2021, using two centres for inflammatory bowel diseases in the Brazilian Public Health System.ResultsThis study included 220 patients. Only perianal disease was associated with hospitalisation (31.6% vs 13.0%, p=0.012). Stricturing or penetrating behaviour (35.8% vs 12.6%, p<0.001) and perianal disease (45.9% vs 9.9%, p<0.001) were associated with surgery. Ileal or ileocolonic location (80.0% vs 46.5%, p=0.044) and stricturing or penetrating behaviour (68.0% vs 11.2%, p<0.001) were associated with intestinal resection. Steroids use at first Crohn’s disease occurrence and postoperative complications were associated with hospital readmission and need for multiple operations, respectively. Age below 40 years at diagnosis (81.3% vs 62.0%, p=0.004), upper gastrointestinal tract involvement (21.8% vs 10.3%, p=0.040) and perianal disease (35.9% vs 16.3%, p<0.001) were associated with immunobiological agent use.ConclusionPerianal disease and stricturing or penetrating behaviour were associated with more than one significant outcome. Other variables related to Crohn’s disease progression were age below 40 years at diagnosis, an ileal or ileocolonic disease localisation, an upper gastrointestinal tract involvement, the use of steroids at the first Crohn’s disease occurrence and history of postoperative complications. These findings are similar to those in the countries with a high prevalence of Crohn’s disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Variables associated with progression of moderate-to-severe Crohn’s disease

Sacramento

Motta

Alves

et al. 2022

BMJ Open Gastroenterol

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“…The cumulative prevalence of IBD has been rising, with 0.1% of Brazilians living with IBD in 2020. 16 …”

Section: Epidemiology Of Ibd In Latammentioning

confidence: 99%

“…8 The largest population of patients with IBD is found in Brazil. A recently published study 16 demonstrated data from 212,026 patients with an IBD diagnosis in 2020 (UC: n = 119,700; CD: n = 71,321; IBD-U: n = 21,005) from the public healthcare system. Stable IBD incidence rates were observed from 2012 to 2020.…”

Section: Epidemiology Of Ibd In Latammentioning

confidence: 99%

IBD barriers across the continents: a continent-specific analysis: Latin America

Queiroz

Martins

Quaresma

et al. 2023

Therap Adv Gastroenterol

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Latin America (LATAM) is a large region comprising 47 countries and territories. Each one carries a different cultural and historical background, diverse political systems, and a particular approach to healthcare management. There is a lack of high-quality data on the epidemiology of inflammatory bowel diseases (IBD) in this region, including broad and detailed information about the penetration of biological and advanced therapies as treatment strategies. From an IBD perspective, patients experience, in general, fragmentations and inequities in the healthcare systems, with different and usually delayed access to qualified health services. This review explores the barriers to accessing IBD care throughout LATAM. The authors compiled data from multiple sources, such as studies focusing on epidemiology, biological penetration, and surgical rates. In addition, overall access to IBD treatments was assessed through a questionnaire distributed to physicians in LATAM via email and direct messaging to capture local perspectives.

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“…IMIDS has been considered for a long time to affect populations mainly from developed countries. Recent epidemiological studies showed that IMIDs is becoming increasingly common among immigrants from developing countries with accelerating incidence of IBD in recently industrialized regions ( Ng et al, 2017 ; Agrawal et al, 2019 ; Quaresma et al, 2022 ). IMIDs are characterized by acute or chronic inflammation that can affect any organ and biological systems, leading to morbidity, reduced quality of life and premature death ( El-Gabalawy et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization

et al. 2023

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Introduction: Formerly named Plectranthusforsteri, Coleus forsteri (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant.Method: Herein, we investigated anti-inflammatory potential of C. forsteri ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers.Results: Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished under ePE and cPE treatment in activated human monocyte-derived macrophages (MDMs). Seven abietane diterpenes were characterized from C. forsteri cPE including coleon U (1), coleon U-quinone (2), 8α,9α-epoxycoleon U-quinone (3), horminone or 7α-hydroxyroyleanone (4), 6β,7α-dihydroxyroyleanone (5), 7α-acetoxy-6β-hydroxyroyleanone (6) and 7α-formyloxy-6β-hydroxyroyleanone (7).Discussion: We discussed potential contributions of these molecules from C. forsteri extracts for their anti-inflammatory activities.

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Temporal trends in the epidemiology of inflammatory bowel diseases in the public healthcare system in Brazil: A large population-based study

Cited by 17 publications

References 27 publications

Variables associated with progression of moderate-to-severe Crohn’s disease

Variables associated with progression of moderate-to-severe Crohn’s disease

IBD barriers across the continents: a continent-specific analysis: Latin America

Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization

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