Temporal Trends of Clinical Characteristics and Treatments in People Living with HIV at the Initiation of Antiretroviral Therapy — Beijing Municipality, China, 2010–2020

Zhang, Jinjuan; Zhou, Mei; Wang, Peicheng; Wang, Duoduo; Mi, Yuanqi; Liu, Jufen; Cao, Feng

doi:10.46234/ccdcw2023.024

Cited by 2 publications

(1 citation statement)

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“…Clinical data were reported by clinicians in four designated HIV treatment hospitals in Beijing: Peking Union Medical College Hospital, Beijing You'an Hospital, Beijing Ditan Hospital and 302 Military Hospital of China. Our analysis included all treatment-naive PLWH who initiated therapy at one of these hospitals between 1 January 2010 and 31 December 2020 [11]. The data were taken directly from the hospital's records on the date that ART was prescribed.…”

Section: E T H O D S 21 Study Design and Populationmentioning

confidence: 99%

Treatment‐naïve people living with HIV aged 50 years or older in Beijing, China, 2010–2020: joinpoint regression model analysis of surveillance data

Wang,

Zhou,

Wang

et al. 2023

J Int AIDS Soc.

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IntroductionAs they age, people living with HIV (PLWH) must face new challenges, such as accelerated ageing and higher rates of comorbidities. This study described the characteristics of HIV acquisition among treatment‐naïve PLWH aged ≥50 years and <50 years in Beijing from 2010 to 2020, exploring associated risk factors for comorbidities.MethodsIn this cross‐sectional study, differences in HIV‐related and non‐HIV‐related characteristics were compared using the t‐test, Mann−Whitney U test and chi‐square test. Temporal trend data were analysed via joinpoint regression. A multivariate logistic regression model was conducted to analyse the associated factors with PLWH having one or more comorbidities.ResultsThe proportion of PLWH aged ≥50 years has significantly increased since 2013, with a corresponding increase in homosexual transmission in this age group over the past decade. The proportion of individuals with CD4 counts <200 cells/μl significantly decreased from 2010 to 2013 among PLWH aged ≥50 years and from 2010 to 2014 among those aged <50 years. Delayed initiation of antiretroviral therapy (ART) improved for both age groups over the course of the decade, especially from 2014 to 2020. Compared to PLWH aged <50 years, those aged ≥50 years had a higher proportion of CD4 counts <200 cells/μl, higher levels of plasma HIV RNA load and a higher prevalence of non‐HIV‐related risk factors. Multivariate analysis revealed that PLWH aged ≥50, male, not single, transmission through heterosexual contact or drug injection, WHO Stage IV, coinfection with hepatitis B virus/hepatitis C virus and CD4 counts <200 cells/μl at the initiation of ART were associated with higher risk of the presence of an HIV comorbidity.ConclusionsDue to the persistent burden of HIV‐related characteristics or symptoms and the increasing prevalence of coexisting comorbidities among treatment‐naïve PLWH aged ≥50 years, physicians should provide the highest‐quality screening, prevention, treatment and management of coexisting comorbidities, adopting a multidisciplinary approach.

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Section: E T H O D S 21 Study Design and Populationmentioning

confidence: 99%

Treatment‐naïve people living with HIV aged 50 years or older in Beijing, China, 2010–2020: joinpoint regression model analysis of surveillance data

Wang,

Zhou,

Wang

et al. 2023

J Int AIDS Soc.

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Global Trends in CD4 Count Measurement and Distribution at First Antiretroviral Treatment Initiation

de Waal,

Wools-Kaloustian,

Brazier

et al. 2024

Clinical Infectious Diseases

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Background While people with HIV (PWH) start antiretroviral treatment (ART) regardless of CD4 count, CD4 measurement remains crucial for detecting advanced HIV disease and evaluating ART programmes. We explored CD4 measurement (proportion of PWH with a CD4 result available) and prevalence of CD4 <200 cells/µL at ART initiation within the International epidemiology Databases to Evaluate AIDS (IeDEA) global collaboration. Methods We included PWH at participating ART programmes who first initiated ART at age 15–80 years during 2005–2019. We described proportions of PWH (i) with CD4 (measured within 6 months before to 2 weeks after ART initiation); and (ii) among those with a CD4, with CD4 <200; by year of ART initiation and region. Results We included 1,355,104 PWH from 42 countries in 7 regions; 63% were female. Median (interquartile range) age at ART initiation was 37 (31–44) in men and 32 (26–39) in women. CD4 measurement initially increased, or remained stable over time until around 2013, but then declined to low levels in some regions (Southern Africa, except South Africa: from 54 to 13%; East Africa 85 to 31%; Central Africa 72 to 20%; West Africa: 91 to 53%; and Latin America: 87 to 56%). Prevalence of CD4<200 declined over time in all regions, but plateaued after 2015 at ≥30%. Conclusions CD4 measurement has declined sharply in recent years, especially in sub-Saharan Africa. Among those with a CD4, the prevalence of CD4 <200 remains concerningly high. Scaling up CD4 testing and securing adequate funding are urgent priorities.

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Temporal Trends of Clinical Characteristics and Treatments in People Living with HIV at the Initiation of Antiretroviral Therapy — Beijing Municipality, China, 2010–2020

Cited by 2 publications

References 10 publications

Treatment‐naïve people living with HIV aged 50 years or older in Beijing, China, 2010–2020: joinpoint regression model analysis of surveillance data

Treatment‐naïve people living with HIV aged 50 years or older in Beijing, China, 2010–2020: joinpoint regression model analysis of surveillance data

Global Trends in CD4 Count Measurement and Distribution at First Antiretroviral Treatment Initiation

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