Temporal Variability–Based Functional Brain Lateralization Study in ADHD

Zou, Hongliang; Yang, Jian

doi:10.1177/1087054719859074

Cited by 20 publications

(15 citation statements)

References 52 publications

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“…Some aspects of brain asymmetry are partly heritable (Guadalupe et al, 2016;Kong et al, 2018), so that future gene mapping studies for brain asymmetry and disorder susceptibility may help to resolve causal relations underlying their associations. One functional imaging study (94 cases, 85 controls) reported lower rightward lateralization in medial orbitofrontal cortex in ADHD compared to controls, based on temporal variability during resting-state (Zou & Yang, 2019). Furthermore, a study of 218 participants with ADHD and 358 healthy controls reported that orbitofrontal cortex thickness, but not surface area, showed a left > right asymmetry in childhood controls that switched to right > left asymmetry by late adolescence, while this change did not occur to the same extent in ADHD (Shaw et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Since then, various neuropsychological and functional imaging studies have found differences between people with ADHD compared to controls (e.g., (Cortese et al, 2012)), with some pointing to a particular involvement of right hemisphere alterations (Geeraerts, Lafosse, Vaes, Vandenbussche, & Verfaillie, 2008;Hale et al,2010Hale et al, , 2014Langleben et al, 2001;Stefanatos & Wasserstein, 2001;Vance et al, 2007). However, not all functional data fit a primarily right-hemisphere model (Hale et al, 2009;Mohamed, Börger, Geuze, & van der Meere, 2016;Zou & Yang, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets

Postema

Hoogman

Ambrosino

et al. 2021

Child Psychology Psychiatry

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Objective: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. Methods: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries. Results: There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from −0.18 to 0.18) and would not survive study-wide correction for multiple testing. Conclusion: Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets

Postema

Hoogman

Ambrosino

et al. 2021

Child Psychology Psychiatry

View full text Add to dashboard Cite

show abstract

“…Some aspects of brain asymmetry are partly heritable (30,38), so that future gene mapping studies for brain asymmetry and disorder susceptibility may help to resolve causal relations underlying their associations. One functional imaging study (94 cases, 85 controls) reported lower rightward lateralization in medial orbitofrontal cortex in ADHD compared to controls, based on temporal variability during resting-state (21). Furthermore, a study of 218 participants with ADHD and 358 healthy controls reported that orbitofrontal cortex thickness, but not surface area, showed a left>right asymmetry in childhood controls that switched to right>left asymmetry by late adolescence, while this change did not occur to the same extent in ADHD (51).…”

Section: Discussionmentioning

confidence: 99%

“…Since then, various neuropsychological and functional imaging studies have found lateralized differences between people with ADHD compared to controls (e.g., (9)(10)(11)(12)(13)(14)), with some pointing to a particular involvement of right hemisphere alterations (15)(16)(17)(18)(19)(20). However, not all functional data fit a primarily righthemisphere model (21). In terms of brain anatomy, several studies have reported altered asymmetry of the caudate nucleus in ADHD, although not consistently in the direction of effect (9,10,(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Analysis of structural brain asymmetries in Attention-Deficit/Hyperactivity Disorder in 39 datasets

Postema

Hoogman

Glahn

et al. 2020

Preprint

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Objective: Some studies have suggested alterations of structural brain asymmetry in attentiondeficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here we performed the largest-ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. Methods: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,978 people with ADHD and unaffected 1,917 controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modelling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.Results: There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t=2.4, P=0.019). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t=2.4, P=0.007) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing. Conclusion: Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.

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“…We next used iSECA to perform genetic overlap analyses 53 with our mvGWAS results in relation to GWAS summary statistics from neurodevelopmental disorders, behavioral and psychological traits which have been reported to associate phenotypically with aspects of structural and/or functional brain asymmetry: attention deficit hyperactivity disorder [54][55][56][57][58] , autism spectrum disorder [59][60][61][62][63][64] , educational attainment 42,65,66 , handedness 4,22,67 , intelligence 43,[68][69][70][71] and schizophrenia [72][73][74][75][76][77] . There was evidence for genetic overlap between brain asymmetries and autism (p=0.005), educational attainment (p=0.001) and schizophrenia (p=0.002) which remained significant at Bonferroni-corrected P<0.05 ( Fig.…”

mentioning

confidence: 99%

The genetic architecture of structural left-right asymmetry of the human brain

Sha

Schijven

Carrión-Castillo

et al. 2020

Preprint

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Left-right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and can be altered in cognitive and psychiatric disorders1-8. No mechanism has yet been identified for establishing the human brain’s left-right axis9. We performed multivariate genome-wide association scanning (mvGWAS) of cortical regional surface area and thickness asymmetries, and subcortical volume asymmetries, using data from 32,256 participants from the UK Biobank. There were 21 significant loci affecting different aspects of brain asymmetry, with functional enrichment involving microtubule-related genes and embryonic brain expression. These findings are consistent with a known role of the cytoskeleton in left-right axis determination in other organs of invertebrates and frogs10-12. Genetic variants affecting brain asymmetry overlapped with those influencing autism, educational attainment and schizophrenia.

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Temporal Variability–Based Functional Brain Lateralization Study in ADHD

Cited by 20 publications

References 52 publications

Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets

Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets

Analysis of structural brain asymmetries in Attention-Deficit/Hyperactivity Disorder in 39 datasets

The genetic architecture of structural left-right asymmetry of the human brain

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