Little
is known about temporal trends of pregnant women’s
exposures to environmental phenols and parabens. We quantified four
phenols [bisphenol A (BPA), bisphenol F, bisphenol S, and triclosan),
four parabens [butyl paraben, ethyl paraben (ETPB), methyl paraben
(MEPB), and propyl paraben (PRPB)], and triclocarban in 760 urine
samples collected during 2007–2014 from 218 California pregnant
women participating in a high-familial risk autism spectrum disorder
cohort. We applied multiple regression to compute least square geometric
means of urinary concentrations and computed average annual percent
changes. We compared our urinary concentrations with those of other
study populations to examine geographic variations in pregnant women’s
exposure to these target compounds. Urinary concentrations of BPA,
MEPB, ETPB, and PRPB in this study population decreased over the study
period [percent change per year (95% confidence interval): −5.7%
(−8.2%, −3.2%); −13.0% (−18.1%, −7.7%);
−5.5% (−11.0%, 0.3%); and −13.3% (−18.3%,
−8.1%), respectively] and were consistently lower than those
in pregnant women in other U.S. regions during the same study period.
In recent years, certain phenols and parabens with known adverse health
effects are being regulated or replaced with alternatives, which explains
decreased body burdens observed in this study population. Either the
national regulations or the advocacy campaigns in California may have
influenced exposures or consumer product choices.