Temporal variation in the recovery from impairment in adriamycin-induced wound healing in rats

Ağuş, Haluk; Dinç, Soykan; Başgut, Bilgen; Abacıoğlu, Nurettin

doi:10.1186/1740-3391-5-6

Cited by 2 publications

(1 citation statement)

References 22 publications

(17 reference statements)

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“…One of the disadvantages of such a concomitant treatment is retardation of healing time of the surgical wound. 2 Most chemotherapeutic drugs act by inhibiting cellular metabolism, rapid cell division, and angiogenesis thereby inhibiting many of the pathways that are crucial to appropriate wound healing. Chemotherapeutic drugs may also delay cell migration into the wound, decrease early wound matrix formation, lower collagen production, impair proliferation of fibroblasts, and inhibit contraction of wounds.…”

Section: Introductionmentioning

confidence: 99%

Wound healing suppressant effect of vincristine reversed by vitamin A: an experimental study

Venkatadri

Khan

2016

Int J Basic Clin Pharmacol

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Section: Introductionmentioning

confidence: 99%

Wound healing suppressant effect of vincristine reversed by vitamin A: an experimental study

Venkatadri

Khan

2016

Int J Basic Clin Pharmacol

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Adjuvant chemotherapy reduces the incidence of abdominal hypertrophic scarring following immediate TRAM breast reconstruction

Lee

Jeong

Eom

et al. 2013

Breast Cancer Res Treat

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Among the many factors that affect the degree of completion and satisfaction of breast reconstruction, the scarring is one issue that a surgeon cannot completely control. We hypothesized that the administration of cytotoxic drugs following the immediate breast reconstruction using transverse rectus abdominis musculocutaneous (TRAM) flap might affect the process of scarring, thus resulting in reduced incidence of hypertrophic scarring at the donor site. Data have been collected from 1,000 consecutive patients between July 2001 and December 2009. The relationship between the adjuvant chemotherapy and the incidence of hypertrophic scarring was studied, and the influence of other presumed risk factors was analyzed. The incidence of hypertrophic scarring was 18.6 % (75 of 404) in the non-CTX group and 3.8 % (20 of 530) in the CTX group. Univariate analysis using logistic regression modeling confirmed the statistical significance of the reducing effect of chemotherapy on the incidence of hypertrophic scarring (p < 0.001; OR: 0.172). The incidence of donor-site hypertrophic scarring following immediate TRAM breast reconstruction was found in nearly 20 % of the patients without chemotherapy, showing a significant difference from the patients with chemotherapy. We believe that Asian patients who undergo immediate TRAM breast reconstruction without chemotherapy are a high-risk group that is prone to hypertrophic scarring, requiring active preventive measures.

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Temporal variation in the recovery from impairment in adriamycin-induced wound healing in rats

Abstract: Background: An adriamycin-induced impairment of wound healing has been demonstrated experimentally in rats. The purpose of this study is to investigate a possible temporal variation in recovery from the impairment of wound healing caused by adriamycin administration.

Cited by 2 publications

References 22 publications

Wound healing suppressant effect of vincristine reversed by vitamin A: an experimental study

Wound healing suppressant effect of vincristine reversed by vitamin A: an experimental study

Adjuvant chemotherapy reduces the incidence of abdominal hypertrophic scarring following immediate TRAM breast reconstruction

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