2018
DOI: 10.1364/boe.9.003335
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Temporally and spatially adaptive Doppler analysis for robust handheld optical coherence elastography

Abstract: Optical coherence elastography (OCE), a functional extension of optical coherence tomography (OCT), can be used to characterize the mechanical properties of biological tissue. A handheld fiber-optic OCE instrument will allow the clinician to conveniently interrogate the localized mechanical properties of tissue, leading to better informed clinical decision making. During handheld OCE characterization, the handheld probe is used to compress the sample and the displacement of the sample is quantified by analyzin… Show more

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Cited by 9 publications
(5 citation statements)
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“…Spatially resolved qOCE imaging is beyond the scope of this study. Imaging results can be found in our previous publications [12][13][14]. as the material's response to the excitation.…”
Section: Qoce Systemmentioning
confidence: 99%
See 1 more Smart Citation
“…Spatially resolved qOCE imaging is beyond the scope of this study. Imaging results can be found in our previous publications [12][13][14]. as the material's response to the excitation.…”
Section: Qoce Systemmentioning
confidence: 99%
“…Compared to other elastography technologies, OCE has much higher spatial resolution and allows mechanical characterization on a small volume of breast tissue. An OCE instrument can be fabricated using fiber-optic components and can be integrated into a handheld probe that is compact and lightweight [12]. Therefore, an OCE instrument will allow convenient assessment of tissue malignancy for margin assessment during breast conserving surgery, and has the potential to significantly improve patient outcome by ensuring negative margin.…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, applications of OCT continue to expand including utilization in the fields of dermatology [26][27][28], the pulmonary system [29,30], the brain [31,32], the urinary tract [33], the middle ear [34][35][36], among numerous others. Further, functional extensions of OCT [37], including angiography [38,39], elastography [40,41], Doppler-OCT [40,42,43], spectroscopic-OCT [44], adaptive optics [45,46], and combined modalities [47][48][49], are continually advanced in efforts to better identify and understand disease. Clinical adoption in these fields depends not just on imaging capabilities but also on adapting OCT to the clinical workflow, including the financial implications of instrument cost and use.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, development of handheld OCT probes has accelerated, driven by increased commercial availability of miniaturized optics and the need for the flexibility of manual manipulation in many clinical applications 4. Various scanning-based handheld OCT probes have been demonstrated for a wide range of applications, such as inner ear imaging,4 retinal angiography,5 elastography,6 and with combined modalities 7. Typically, handheld probes enclose the OCT scanner arm within a manufactured housing 8.…”
Section: Introductionmentioning
confidence: 99%