Temporally Distinct Roles for the Zinc Finger Transcription Factor Sp8 in the Generation and Migration of Dorsal Lateral Ganglionic Eminence (dLGE)-Derived Neuronal Subtypes in the Mouse

Kuerbitz, Jeffrey; Madhavan, Mayur; Ehrman, Lisa A.; Kohli, Vikram; Waclaw, Ronald R.; Campbell, Kenneth

doi:10.1093/cercor/bhaa323

Cited by 8 publications

(3 citation statements)

References 85 publications

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“…9 ). This linkage is consistent with reports that cells in mouse dLGE initially express SP8 and maintain TSHZ1 expression as they migrate via the LMS to become amygdala ITCs 19 , 25 . This developmental perspective suggests that these cells are not eccentric deviations from canonical spiny projection neuron development; instead, the LGE_FOXP2/TSHZ1 class converges on a similar striatal and amygdaloid projection neuron transcription profile despite its distinct origin.…”

Section: Reuse Of Ob Neurons In Primate Cerebrumsupporting

confidence: 92%

The development and evolution of inhibitory neurons in primate cerebrum

Schmitz

Sandoval

Chen

et al. 2022

Nature

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Neuroanatomists have long speculated that expanded primate brains contain an increased morphological diversity of inhibitory neurons (INs)1, and recent studies have identified primate-specific neuronal populations at the molecular level2. However, we know little about the developmental mechanisms that specify evolutionarily novel cell types in the brain. Here, we reconstruct gene expression trajectories specifying INs generated throughout the neurogenic period in macaques and mice by analysing the transcriptomes of 250,181 cells. We find that the initial classes of INs generated prenatally are largely conserved among mammals. Nonetheless, we identify two contrasting developmental mechanisms for specifying evolutionarily novel cell types during prenatal development. First, we show that recently identified primate-specific TAC3 striatal INs are specified by a unique transcriptional programme in progenitors followed by induction of a distinct suite of neuropeptides and neurotransmitter receptors in new-born neurons. Second, we find that multiple classes of transcriptionally conserved olfactory bulb (OB)-bound precursors are redirected to expanded primate white matter and striatum. These classes include a novel peristriatal class of striatum laureatum neurons that resemble dopaminergic periglomerular cells of the OB. We propose an evolutionary model in which conserved initial classes of neurons supplying the smaller primate OB are reused in the enlarged striatum and cortex. Together, our results provide a unified developmental taxonomy of initial classes of mammalian INs and reveal multiple developmental mechanisms for neural cell type evolution.

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Section: Reuse Of Ob Neurons In Primate Cerebrumsupporting

confidence: 92%

The development and evolution of inhibitory neurons in primate cerebrum

Schmitz

Sandoval

Chen

et al. 2022

Nature

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“…2k, Supplementary Movies 1 and 2). Our analysis also revealed limited overlap (~13%) at P7 of the PL Dcx + cells and Tshz1, which primarily marks dorsal lateral ganglionic eminence (dLGE)-derived cells that populate the ITCs [49][50][51] . This fraction significantly decreased with age (Extended Data Fig.…”

Section: The Pl Contains a High Density Of Tbr1 + Excitatory Neuronsmentioning

confidence: 80%

“…Our prior single nuclei RNA-sequencing studies further identified BCL11B/CTIP2 as a putative PL marker in humans 7 . We assessed FoxP2 and Tshz1 expression, which label the ITCs [49][50][51] , the dense GABAergic cell clusters adjacent to the BLA, and SatB2, a marker of the vEN [52][53][54] . We also examined expression of the pallial marker Pax6 55 , and Sp8, a marker of migratory interneurons in the RMS 56 .…”

Section: The Pl Contains a High Density Of Tbr1 + Excitatory Neuronsmentioning

confidence: 99%

Mouse paralaminar amygdala excitatory neurons migrate and mature during adolescence

Alderman

Saxon

Torrijos-Saiz

et al. 2022

Preprint

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The human amygdala paralaminar nucleus (PL) contains immature excitatory neurons that exhibit protracted maturation into adolescence; however, whether a similar population exists in mice is unknown. We discovered a previously undescribed region with immature doublecortin (Dcx)+ excitatory neurons adjacent to the mouse basolateral amygdala, and similar to humans, these neurons mature during adolescence and are distinct from adjacent intercalated cells. Despite their immature features, these neurons are born during embryogenesis, populate the mouse PL prior to birth, and remain in an immature stage of development until adolescence. In the postnatal brain, a subpopulation of these excitatory neurons surprisingly migrate into the neighboring endopiriform cortex, peaking between P21-P28. In humans, cells with the molecular identity of mouse PL neurons populate the PL as early as 18 gestational weeks, and also exhibit migratory morphology into adolescence (13 years). The finding of a similar region in both mice and humans suggests a potentially conserved cellular mechanism for neuron recruitment and migration during adolescence, a key time period for amygdala circuit maturation and behavioral changes.

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