Temporary remission of disseminated paecilomycosis in a German shepherd dog treated with ketoconazole : case report

Booth, M.J.; Lugt, Jaco J. Van der; Heerden, A. Van; Picard, J.

doi:10.4102/jsava.v72i2.628

Cited by 17 publications

(16 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diskospondylitis is an infection of the intervertebral disk and the adjacent endplates. The agent is usually bacterial, although fungal infections have been reported 5–11 . Direct inoculation of an organism into the region is uncommon, but can occur as a result of spinal surgery, penetrating wound, regional abscessation, or migration of foreign material (e.g., plant awn) 5,6,12,13 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sublumbar Abscess and Diskospondylitis in a Cat

Packer

Coates

Cook

et al. 2005

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Diskospondylitis is uncommon in cats. We describe a cat with diskospondylitis of the L7-S1 intervertebral disk, and a concurrent sublumbar abscess. Radiographic, computed tomographic and ultrasonographic findings are presented. Aerobic and anaerobic cultures of blood and spinal fluid yielded no growth. Aerobic and anaerobic urine cultures resulted in growth of an Enterococcus sp. and Clostridium perfringens, respectively. The cat was successfully treated with enrofloxacin and amoxicillin/clavulanic acid. Clinical signs resolved completely, and based on follow-up ultrasonography there was no remaining evidence of the sublumbar abscess. Etiologic agents and outcome from other cats with diskospondylitis are reviewed.

show abstract

Section: Discussionmentioning

confidence: 99%

“…and Paecilomyces spp. have also been identified 7–9,16 . Fungal organisms may be difficult to diagnose without cytologic or histopathologic evaluation 9 …”

Section: Discussionmentioning

confidence: 99%

Sublumbar Abscess and Diskospondylitis in a Cat

Packer

Coates

Cook

et al. 2005

Vet Radiology Ultrasound

View full text Add to dashboard Cite

show abstract

“…10,[16][17][18]20,21,39,40 Clinical signs of disease often vary from local paraspinal pain to evidence of systemic infection. As disease progresses, neurologic deficits consistent with extradural compression may develop.…”

Section: Discussionmentioning

confidence: 99%

“…The dogs reported in the literature with fungal discospondylitis are German Shepherds or German Shepherd crosses. [16][17][18][19][20][21][22][23][24][25] There may be a relationship in German Shepherds with defective immunoglobulin A production and altered mucosal immunity that allows the initial penetration of the fungus. 43 Thus, this breed may have a specific inability to mount an effective response against opportunistic fungi.…”

Section: Discussionmentioning

confidence: 99%

Isolation and characterisation of the fungusSpiromastix asexualissp. nov. from discospondylitis in aGermanShepherd dog, and review ofSpiromastixwith the proposal of the new orderSpiromastixales (Ascomycota)

Rizzo

Sutton

Wiederhold

et al. 2014

Mycoses

View full text Add to dashboard Cite

The genus Spiromastix consists of several fungal species that have been isolated from soil and animal dung in various parts of the world. However, these species are considered to be of low pathogenic potential, as no cases of infections caused by these fungi have been reported. Here, we describe the clinical course of discospondylitis in a dog from which a fungus was cultured from a biopsy and identified as a Spiromastix species by morphologic characteristics and sequencing. Phylogenetic analysis determined this to be a new species, Spiromastix asexualis, which is described, and a new order, Spiromastixales, is proposed.

show abstract

“…It is well established that certain individuals within the German Shepherd breed are at increased risk of developing fungal infections, especially disseminated infections with filamentous fungi 1–12 …”

mentioning

confidence: 99%

Sequential opportunistic infections in two German Shepherd dogs

et al. 2011

View full text Add to dashboard Cite

Two German Shepherd dogs with sequential opportunistic infections are described. The first was a 2-year-old male with cryptococcal rhinitis that spread to involve the optic nerves and brain. It was successfully treated with combination therapy utilising amphotericin B administered for 2 years, but the dog developed a disseminated Aspergillus deflectus infection 5 years later and was euthanased. The second case was a 4-year-old male that presented for a severe, deep-seated infection of the right antebrachium, with gradual extension to contiguous tissues. Neosartorya fischeri (anamorph; Aspergillus fischerianus) was isolated in pure culture and detected in histological sections. The infection was refractory to itraconazole, but resolved after amputation of the affected limb. Five months later, the dog developed a localised cutaneous lesion on the proximal pelvic limb, from which Pythium insidiosum was isolated and then visualised in tissue sections, together with a structure thought to be grass seed. This lesion was treated by wide surgical resection, although it was reported that the dog died of disseminated disease some months later. These cases provide further circumstantial evidence that young adult German Shepherd dogs have a predilection to developing invasive infections with fungi and other saprophytic pathogens.

show abstract

Temporary remission of disseminated paecilomycosis in a German shepherd dog treated with ketoconazole : case report

Cited by 17 publications

References 10 publications

Sublumbar Abscess and Diskospondylitis in a Cat

Sublumbar Abscess and Diskospondylitis in a Cat

Isolation and characterisation of the fungusSpiromastix asexualissp. nov. from discospondylitis in aGermanShepherd dog, and review ofSpiromastixwith the proposal of the new orderSpiromastixales (Ascomycota)

Sequential opportunistic infections in two German Shepherd dogs

Contact Info

Product

Resources

About