Temporary tarsorrhaphy in the rat

Brown, Cyndi

doi:10.1038/laban0107-25

Lab Anim

2007

DOI: 10.1038/laban0107-25

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Temporary tarsorrhaphy in the rat

Cyndi Brown¹

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Cited by 3 publications

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Animal Models for Limbal Stem Cell Deficiency: A Critical Narrative Literature Review

Atalay,

Altuğ,

Çalışkan

et al. 2024

Ophthalmol Ther

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This literature review will provide a critical narrative overview of the highlights and potential pitfalls of the reported animal models for limbal stem cell deficiency (LSCD) and will identify the neglected aspects of this research area. There exists significant heterogeneity in the literature regarding the methodology used to create the model and the predefined duration after the insult when the model is supposedly fully fit for evaluations and/or for testing various therapeutic interventions. The literature is

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Animal Models for Limbal Stem Cell Deficiency: A Critical Narrative Literature Review

Atalay,

Altuğ,

Çalışkan

et al. 2024

Ophthalmol Ther

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Direct oral mucosal epithelial transplantation supplies stem cells and promotes corneal wound healing to treat refractory persistent corneal epithelial defects

Gong

Yan

et al. 2022

Experimental Eye Research

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Cause and Treatment of Exophthalmos in Aged Cotton Rats (Sigmodon hispidus)

et al. 2020

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Aged cotton rats (Sigmodon hispidus) from an established breeding colony displayed signs of spontaneous exophthalmos. Of a total of 118 colony animals that were older than 6 mo of age, 37 (31%) displayed signs of exophthalmos. These rats were clinically healthy and had no other signs of disease. Ophthalmic exams, molecular and microbiologic testing, and histopa- thology were performed to determine the cause of the exophthalmos and to provide appropriate treatment. Environmental monitoring records were also reviewed for vivarium rooms in which the cotton rats were housed. Histopathology findings supported that the exophthalmos in these cotton rats was secondary to retro-orbital thrombosis associated with cardiomyopathy. The exophthalmic eyes were treated by either removal of the affected eye (enucleation) or surgical closure of the eyelids (temporary tarsorraphy). Enucleation of the exophthalmic eye was the best intervention for these aged cotton rats. These findings demonstrate the potential for a high incidence of ocular problems occurring secondary to cardiomyopathy in aged cotton rats. Enucleation as a therapeutic intervention for exophthalmic eyes in aged cotton rats prolongs the morbidity-free time span during which these aged animals can be used experimentally.

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Temporary tarsorrhaphy in the rat

Cited by 3 publications

References 4 publications

Animal Models for Limbal Stem Cell Deficiency: A Critical Narrative Literature Review

Animal Models for Limbal Stem Cell Deficiency: A Critical Narrative Literature Review

Direct oral mucosal epithelial transplantation supplies stem cells and promotes corneal wound healing to treat refractory persistent corneal epithelial defects

Cause and Treatment of Exophthalmos in Aged Cotton Rats (Sigmodon hispidus)

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