Temporary Wettability Tuning of PCL/PDMS Micro Pattern Using the Plasma Treatments

Lin, Wei-Chih; Razali, Nur Adila Mohd

doi:10.3390/ma12040644

Cited by 26 publications

(17 citation statements)

References 49 publications

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“…There are several advantages to surface activation of biomaterials with oxygen plasma beyond biocompatibility. Typically, surface oxidation for hydrophilization occurs only within a depth of 5–50 nm from the surface, indicating that plasma activation does not alter the bulk properties of the materials 41,42 . Therefore, the materials can maintain their mechanical properties such as strength, flexibility, formability, stability/degradability while the surfaces are modified to be more bioactive 18 .…”

Section: Discussionmentioning

confidence: 99%

Surface activation with oxygen plasma promotes osteogenesis with enhanced extracellular matrix formation in three‐dimensional microporous scaffolds

Yamada

Yassin

Weigel

et al. 2021

J Biomedical Materials Res

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Various types of synthetic polyesters have been developed as biomaterials for tissue engineering. These materials commonly possess biodegradability, biocompatibility, and formability, which are preferable properties for bone regeneration. The major challenge of using synthetic polyesters is the result of low cell affinity due to their hydrophobic nature, which hinders efficient cell seeding and active cell dynamics. To improve wettability, plasma treatment is widely used in industry. Here, we performed surface activation with oxygen plasma to hydrophobic copolymers, poly(l‐lactide‐co‐trimethylene carbonate), which were shaped in 2D films and 3D microporous scaffolds, and then we evaluated the resulting surface properties and the cellular responses of rat bone marrow stem cells (rBMSC) to the material. Using scanning electron microscopy and Fourier‐transform infrared spectroscopy, we demonstrated that short‐term plasma treatment increased nanotopographical surface roughness and wettability with minimal change in surface chemistry. On treated surfaces, initial cell adhesion and elongation were significantly promoted, and seeding efficiency was improved. In an osteoinductive environment, rBMSC on plasma‐treated scaffolds exhibited accelerated osteogenic differentiation with osteogenic markers including RUNX2, osterix, bone sialoprotein, and osteocalcin upregulated, and a greater amount of collagen matrix and mineral deposition were found. This study shows the utility of plasma surface activation for polymeric scaffolds in bone tissue engineering.

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Section: Discussionmentioning

confidence: 99%

Surface activation with oxygen plasma promotes osteogenesis with enhanced extracellular matrix formation in three‐dimensional microporous scaffolds

Yamada

Yassin

Weigel

et al. 2021

J Biomedical Materials Res

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“…These results are very important to determinate the function of a wound dressing. Hydrophobic surfaces are suitable for bacterial adsorption, although, a wound dressing with hydrophilic surface is needed to improve cell attachment for most anchorage‐dependent cell types 46 . Dressings have their unique characteristics and applications then further investigations are crucial to finding an enhanced treatment option for wound healing 22…”

Section: Resultsmentioning

confidence: 99%

Antibiotic‐loaded wound dressings obtained from the PBAT‐gentamicin combination

Scheibel

Menezes

Reginatto

et al. 2021

J of Applied Polymer Sci

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The development of biodegradable curative systems containing antibacterial drug are fundamental for the promotion of therapeutic actions, reducing the infections caused by microorganisms and being able to substitute conventional dressings which are not biodegradable polymers in their composition. Meeting those needs, poly (butylene adipate‐co‐terephthalate) (PBAT) and PBAT/gentamicin (GT) fibers were electrospun using different concentrations of GT. The physical–chemical, morphological, thermal, antibacterial, and biological properties of the PBAT and PBAT/GT fibers were characterized. The presence of GT modified the mean diameter, roughness, and wettability of the prepared fibers. The degree of swelling was altered with the addition of GT. PBAT/GT fibers showed antibacterial activity against Escherichia coli strains reaching an inhibitory activity above 90% in the films with 2%, 5%, and 10% of GT. In addition, the fibers did not present cytotoxicity according to ISO 10993‐5 standard. The obtained results reinforce that PBAT can be used as a curative system.

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“…Wettability studies engage with contact angle measurements as the primary data, which indicate the degree of wetting when solid and liquid objects interact . Hydrophilic surfaces with small contact angles (less than 90°) corresponded to high wettability, while hydrophobic surfaces with large contact angles (more than 90°) corresponded to low wettability . Due to the chemistry on the surface, the surface roughness will enhance wettability.…”

Section: Resultsmentioning

confidence: 99%

Polycaprolactone blends for fracture fixation in low load‐bearing applications

Bou-Francis

Piercey

Al-Qatami

et al. 2020

J of Applied Polymer Sci

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There is a need to replace surgical plates and screws in orthopedic surgery. Absorbable polymers are an alternative to metal where load bearing is of a less concern. Polycaprolactone (PCL) is biocompatible, yet it has low mechanical strength and its surface chemistry does not promote cell adhesion. The objective of this work was to create PCL adhesive blends with poly(glycolic) acid (PGA), thermoplastic starch (TPS), chitosan, and tricalcium phosphate (TCP) to be used as potential fracture fixation devices. The differential scanning calorimetry (DSC) data showed that the primary melting points (T m1 C) of blends were often lower than PCL, with the exception of chitosan blends, which may indicate an improvement for surgical use. PCL/PGA blends showed secondary and tertiary melting points (T m ) and enthalpies (ΔH m ) indicating poor miscibility of PGA in the blends. The binary PCL/TCP mixture has a higher enthalpy compared to the binary PCL/PGA blend, but the secondary melting temperature is lower in ternary mixtures. Ternary blends of PCL/PGA/TCP, however, retained the adhesive strength of the parent PCL adhesive while having an improvement in hydrophilicity. These blends are recommended for fracture fixation devices especially in low load-bearing applications such as maxillofacial surgery, orthopedics, and neurosurgery.

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Temporary Wettability Tuning of PCL/PDMS Micro Pattern Using the Plasma Treatments

Cited by 26 publications

References 49 publications

Surface activation with oxygen plasma promotes osteogenesis with enhanced extracellular matrix formation in three‐dimensional microporous scaffolds

Surface activation with oxygen plasma promotes osteogenesis with enhanced extracellular matrix formation in three‐dimensional microporous scaffolds

Antibiotic‐loaded wound dressings obtained from the PBAT‐gentamicin combination

Polycaprolactone blends for fracture fixation in low load‐bearing applications

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