Temporary worsening of parkinsonism in a patient with Parkinson's disease after treatment with paclitaxel for a metastatic grade IV adenocarcinoma

Bower, James H.; Muenter, Manfred D.

doi:10.1002/mds.870100528

Cited by 13 publications

(6 citation statements)

References 3 publications

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“…Neurological adverse events that may occur after exposure to these drugs include encephalopathy, seizures, peripheral neuropathy, and cranial nerve dysfunction 1–4. A few reports have described de novo parkinsonism5–13 or worsening of preexisting Parkinson's disease14–16 after exposure to chemotherapy. In some cases, a single agent is responsible, whereas in others, multiple drugs are likely involved, especially in association with bone marrow transplantation 7–9.…”

mentioning

confidence: 99%

Chemotherapy‐induced parkinsonism responsive to levodopa: An underrecognized entity

et al. 2002

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Parkinsonism is a rare neurological complication of cancer treatment. Although individual case reports of this syndrome have been reported, the clinical features and prevalence of this syndrome are unknown. We present 3 patients, encountered over 6 months at one institution, who developed parkinsonism after treatment with various chemotherapeutic agents. Parkinsonism was severe in 2 patients, affecting postural reflexes, speech, and swallowing. All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated.

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confidence: 99%

Chemotherapy‐induced parkinsonism responsive to levodopa: An underrecognized entity

et al. 2002

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“…Parkinsonism may also follow viral infections, for example von Economo's encephalitis [4], Japanese B encephalitis [5], Coxsackie B2 infection, West Nile infection, or human immunodeficiency virus infection. Chemotherapeutic agents or treatments for central nervous system malignancy may also trigger acute parkinsonism, either by causing direct injury to the basal ganglia (irradiation for bone marrow transplant [6]) or selective nigral toxicity (cytosine arabinoside [7], paclitaxel [8]). Other drugs that can also trigger acute parkinsonism include selective serotonin reuptake inhibitors, buproprion, lithium, valproate, cyclosporin, amiodarone, captopril, amlodipine, meperidine, and vincristine.…”

Section: Acute Parkinsonismmentioning

confidence: 99%

Treatment of Movement Disorder Emergencies

Frucht

2014

Neurotherapeutics

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Movement disorder emergencies are defined as clinical scenarios where a movement disorder develops over hours to days, and in which morbidity and even mortality can result from failure to appropriately diagnose and manage the patient. The last decade has seen increasing recognition of various movement disorder emergencies, including acute parkinsonism, neuroleptic malignant syndrome, respiratory compromise in multiple system atrophy, dystonic storm, oculogyric crisis, and hemiballism, among others. This article will review the major movement disorder emergencies encountered in the hospital and office, emphasizing practical management and treatment.

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“…These patients differ in that MRI imaging was normal and their symptoms responded to levodopa. Paclitaxel [13], cystosine arabinoside [83], cyclophosphamide and etoposide [37], vincristine and adriamycin [12], and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone, [57]) are reported triggers. The response to levodopa and tendency to recover spontaneously suggests a reversible presynaptic inhibition of the nigrostriatal pathway.…”

Section: Acute Parkinsonismmentioning

confidence: 99%

Movement disorder emergencies

Poston

Frucht

2008

J Neurol

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Movement disorder emergencies include any movement disorder which evolves over hours to days, in which failure to appropriately diagnose and manage can result in patient morbidity or mortality. It is crucial that doctors recognize these emergencies with accuracy and speed by obtaining the proper history and by being familiar with the phenomenology of frequently encountered movements. These disorders will be discussed based on the most common associated involuntary movement, either parkinsonism, dystonia, chorea, tics or myoclonus, and, when available, review the workup and treatment options based on the current literature.

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Temporary worsening of parkinsonism in a patient with Parkinson's disease after treatment with paclitaxel for a metastatic grade IV adenocarcinoma

Cited by 13 publications

References 3 publications

Chemotherapy‐induced parkinsonism responsive to levodopa: An underrecognized entity

Chemotherapy‐induced parkinsonism responsive to levodopa: An underrecognized entity

Treatment of Movement Disorder Emergencies

Movement disorder emergencies

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