Temporomandibular disorder in patients with juvenile idiopathic arthritis: clinical evaluation and correlation with the findings of cone beam computed tomography

Júnior, Antônio Márcio Lima Ferraz; Devito, Karina Lopes; Guimarães, Josemar Parreira

doi:10.1016/j.oooo.2012.02.010

Cited by 28 publications

(13 citation statements)

References 28 publications

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“…The fact that ectopic/enhanced MMP activity was observed in the articular disc of the Shox2 SHOX-KI/KI TMJ suggests a similar mechanism for this congenital degenerative process. Most incidents of TMJ disorder in humans occur after an infection or a trauma, but congenital cases, although rare, have been reported (Ferraz et al, 2012; Gu et al, 2008; Mortazavi and Motamedi, 2007). While the congenital TMJ ankylosis has been reported to a patient with a short stature phenotype (Komorowska, 1997), genetic alterations that cause congenital articular disc degeneration of the TMJ are completely unknown.…”

Section: Resultsmentioning

confidence: 99%

Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice

Liu

et al. 2013

Cell Tissue Res

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The temporomandibular joint (TMJ) consists of the glenoid fossa arising from the otic capsule through intramembranous ossification, the fibrocartilaginous disc and the condyle, derived from the secondary cartilage by endochondral ossification. We have reported previously that cranial neural crest-specific inactivation of the homeobox gene Shox2, which is expressed in the mesenchymal cells of maxilla-mandibular junction and later in the progenitor cells and perichondrium of the developing chondyle, led to dysplasia and ankylosis of the TMJ, and replacement of the mouse Shox2 with the human SHOX gene rescued the dysplastic and ankylosis phenotypes but developed a prematurely worn out articular disc. In this study, we investigated the molecular and cellular bases for the premature wear out articular disc in the TMJ of mice carrying the human SHOX replacement allele in the Shox2 locus (referred as Shox2SHOX-KI/KI). We found that the developmental process and expression of several key genes in the TMJ of Shox2SHOX-KI/KI mice appeared similar to the controls. However, the disc of the Shox2SHOX-KI/KI TMJ exhibited a reduced level of Col I and Aggrecan, accompanied by increased activities of matrix metalloproteinases (MMPs) and a down-regulation of Ihh expression. Dramatically increased cell apoptosis in the disc was also observed. These combinatory cellular and molecular defects appear to contribute to the observed disc phenotype, suggesting that while the human SHOX can exert similar function as the mouse Shox2 in regulating early TMJ development, it apparently has a distinct function in the regulation of those molecules that are involved in tissue homeostasis.

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Section: Resultsmentioning

confidence: 99%

Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice

Liu

et al. 2013

Cell Tissue Res

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“…A clinical evaluation according to the research diagnostic/TMD criteria 78 revealed only a few of the patients with JIA with TMJ bone abnormalities on CBCT. 79 CBCT was used to measure condylar volume or 3D asymmetry in patients with JIA. 80,81 It was also applied to patients with unilateral TMJ involvement undergoing splint therapy to reduce the mandibular asymmetry.…”

Section: Juvenile Idiopathic Arthritismentioning

confidence: 99%

Temporomandibular joint diagnostics using CBCT

Ak²,

Kristensen³

et al. 2015

Dentomaxillofacial Radiology

229

128

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The present review will give an update on temporomandibular joint (TMJ) imaging using CBCT. It will focus on diagnostic accuracy and the value of CBCT compared with other imaging modalities for the evaluation of TMJs in different categories of patients; osteoarthritis (OA), juvenile OA, rheumatoid arthritis and related joint diseases, juvenile idiopathic arthritis and other intra-articular conditions. Finally, sections on other aspects of CBCT research related to the TMJ, clinical decision-making and concluding remarks are added. CBCT has emerged as a cost-and dose-effective imaging modality for the diagnostic assessment of a variety of TMJ conditions. The imaging modality has been found to be superior to conventional radiographical examinations as well as MRI in assessment of the TMJ. However, it should be emphasized that the diagnostic information obtained is limited to the morphology of the osseous joint components, cortical bone integrity and subcortical bone destruction/production. For evaluation of soft-tissue abnormalities, MRI is mandatory. There is an obvious need for research on the impact of CBCT examinations on patient outcome.

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“…17,22 Previous research on TMJ abnormality and dentofacial development in JIA was primarily based on conventional radiological techniques, 11,14,23,24 and only few studies with more advanced techniques exist. [25][26][27][28][29] The introduction of cone beam computed tomography (CBCT), a cost-and dose-effective three-dimensional imaging modality, has enabled the radiological examination of TMJ hard tissue pathologies, which is superior to conventional radiological methods. 30 The aim of this cross-sectional CBCT-based study was to associate radiological TMJ abnormalities with the degree of dentofacial asymmetry in patients with unilateral TMJ involvements.…”

Section: Introductionmentioning

confidence: 99%

No association between types of unilateral mandibular condylar abnormalities and facial asymmetry in orthopedic-treated patients with juvenile idiopathic arthritis

Stoustrup

Ahlefeldt-Laurvig-Lehn

Kristensen

et al. 2018

American Journal of Orthodontics and Dentofacial Orthopedics

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Temporomandibular disorder in patients with juvenile idiopathic arthritis: clinical evaluation and correlation with the findings of cone beam computed tomography

Cited by 28 publications

References 28 publications

Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice

Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice

Temporomandibular joint diagnostics using CBCT

No association between types of unilateral mandibular condylar abnormalities and facial asymmetry in orthopedic-treated patients with juvenile idiopathic arthritis

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