Temporomandibular Disorder Modifies Cortical Response to Tactile Stimulation

Nebel, Mary Beth; Folger, Stephen; Tommerdahl, Mark; Hollins, Mark; McGlone, Francis; Essick, Gregory K

doi:10.1016/j.jpain.2010.02.021

Cited by 39 publications

(53 citation statements)

References 72 publications

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“…Central processing of innocuous stimulation was found to be abnormal in patients with idiopathic pain disorders who perceive tactile, pressure, heat, and auditory innocuous stimuli as more intense than healthy controls . One interpretation of the association between persistent pain and abnormal sensitivity to innocuous stimuli is a balance disruption between central noxious and non‐noxious processing, expressed by increased magnitude and abnormal topography of cortical innocuous processing .…”

Section: Discussionmentioning

confidence: 99%

Sensory Over‐Responsiveness among Healthy Subjects is Associated with a Pronociceptive State

2017

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Section: Discussionmentioning

confidence: 99%

Sensory Over‐Responsiveness among Healthy Subjects is Associated with a Pronociceptive State

2017

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“…The fMRI study used 4s-duration vibrotactile flutter stimuli with 400 μm amplitude delivered at 26 Hz, stimulus parameters allowing comparison to optical imaging results in squirrel monkeys [133]. Ratings suggest that a group of 13 TMD patients perceived this flutter stimulus to be more intense than controls.…”

Section: Neuroimaging Of Brain Activity Evoked By Non-painful Stimulamentioning

confidence: 99%

Neuroimaging of Central Sensitivity Syndromes: Key Insights from the Scientific Literature

Walitt

Čeko²,

Gracely³

et al. 2016

CRR

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Central sensitivity syndromes are characterized by distressing symptoms, such as pain and fatigue, in the absence of clinically obvious pathology. The scientific underpinnings of these disorders are not currently known. Modern neuroimaging techniques promise new insights into mechanisms mediating these postulated syndromes. We review the results of neuroimaging applied to five central sensitivity syndromes: fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, temporomandibular joint disorder, and vulvodynia syndrome. Neuroimaging studies of basal metabolism, anatomic constitution, molecular constituents, evoked neural activity, and treatment effect are compared across all of these syndromes. Evoked sensory paradigms reveal sensory augmentation to both painful and non-painful stimulation. This is a transformative observation for these syndromes, which were historically considered to be completely of hysterical or feigned in origin. However, whether sensory augmentation represents the cause of these syndromes, a predisposing factor, an endophenotype, or an epiphenomenon cannot be discerned from the current literature. Further, the result from cross-sectional neuroimaging studies of basal activity, anatomy, and molecular constituency are extremely heterogeneous within and between the syndromes. A defining neuroimaging “signature” cannot be discerned for any of the particular syndromes or for an over-arching central sensitization mechanism common to all of the syndromes. Several issues confound initial attempts to meaningfully measure treatment effects in these syndromes. At this time, the existence of “central sensitivity syndromes” is based more soundly on clinical and epidemiological evidence. A coherent picture of a “central sensitization” mechanism that bridges across all of these syndromes does not emerge from the existing scientific evidence.

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“…Some more recent studies have consistently indicated generalised disturbances in somatosensory function in different subsets of TMD patients (e.g. 64,126,[218][219][220][221][222][223][224].…”

Section: Influence Of Oro-facial Pain Conditionsmentioning

confidence: 99%

Guidelines and recommendations for assessment of somatosensory function in oro-facial pain conditions - a taskforce report

Svensson

Baad‐Hansen

Pigg

et al. 2011

Journal of Oral Rehabilitation

174

203

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Summary The goals of an international taskforce on somatosensory testing established by the Special Interest Group of Oro-facial Pain (SIG-OFP) under the International Association for the Study of Pain (IASP) were to (i) review the literature concerning assessment of somatosensory function in the oro-facial region in terms of techniques and test performance, (ii) provide guidelines for comprehensive and screening examination procedures, and (iii) give recommendations for future development of somatosensory testing specifically in the oro-facial region. Numerous qualitative and quantitative psychophysical techniques have been proposed and used in the description of oro-facial somatosensory function. The selection of technique includes time considerations because the most reliable and accurate methods require multiple repetitions of stimuli. Multiple-stimulus modalities (mechanical, thermal, electrical, chemical) have been applied to study oro-facial somatosensory function. A battery of different test stimuli is needed to obtain comprehensive information about the functional integrity of the various types of afferent nerve fibres. Based on the available literature, the German Neuropathic Pain Network test battery appears suitable for the study of somatosensory function within the oro-facial area as it is based on a wide variety of both qualitative and quantitative assessments of all cutaneous somatosensory modalities. Furthermore, these protocols have been thoroughly described and tested on multiple sites including the facial skin and intra-oral mucosa. Standardisation of both comprehensive and screening examination techniques is likely to improve the diagnostic accuracy and facilitate the understanding of neural mechanisms and somatosensory changes in different oro-facial pain conditions and may help to guide management. assessments of all cutaneous somatosensory modalities. Furthermore, these protocols have been thoroughly described and tested on multiple sites including the facial skin and intraoral mucosa.Standardization of both comprehensive and screening examination techniques is likely to improve the diagnostic accuracy and facilitate the understanding of neural mechanisms and somatosensory changes in different orofacial pain conditions and may help to guide management.

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Temporomandibular Disorder Modifies Cortical Response to Tactile Stimulation

Cited by 39 publications

References 72 publications

Sensory Over‐Responsiveness among Healthy Subjects is Associated with a Pronociceptive State

Sensory Over‐Responsiveness among Healthy Subjects is Associated with a Pronociceptive State

Neuroimaging of Central Sensitivity Syndromes: Key Insights from the Scientific Literature

Guidelines and recommendations for assessment of somatosensory function in oro-facial pain conditions - a taskforce report

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