Temporomandibular Joint Arthrocentesis and Microfragmented Adipose Tissue Injection for the Treatment of Internal Derangement and Osteoarthritis: A Randomized Clinical Trial

Treatment of Mandibular Hypomobility by Injections into the Temporomandibular Joints: A Systematic Review of the Substances Used

“…The increase in mandibular mobility did not exceed 12% in the analyzed studies [44,49]. The obtained results are clearly worse than in the case of administering analgesics or transplants, which perhaps should be explained by the lack of arthrocentesis before the prolotherapy [39,44,45,49,62]. Sit et al, indicate that a review of studies on dextrose injection shows statistically significant results in favor of prolotherapy in relation to the control groups [92].…”

“…Publication Year First Author Diagnosis Intervention Substance Comparison Group Ghoneim [38] DDwR R+A I-PRF R * Sembronio [39] ID, OA R+A Adipose tissue R+HA * Sembronio [39] ID, OA R+A HA R+Adipose tissue * Karadayi [40] ID R+A I-PRF R * Jacob [41] DDwR, DDwoR R+A PRP R * Jacob [41] DDwR, DDwoR R+A HA R * Singh [42] ID R+A PRP R * Dolwick [43] P R+A CS R+Placebo * Zarate [44] P A Dextrose+Lidocaine Lidocaine * De Riu [45] DD R+A HA R+Bone marrow * De Riu [45] DD R+A Bone marrow R+HA * Yilmaz [46] ID A HA R+HA * Yilmaz [46] ID R+A HA HA * Bergstrand [47] OA R+A HA R * Isacsson [48] P A CS Placebo * Louw [49] P A Dextrose+Lidocaine Lidocaine * Gokçe Kutuk [50] P A HA CS * Gokçe Kutuk [50] P A CS HA * Gokçe Kutuk [50] P A PRP CS * Diaz [51] P R+A CS R+Placebo * Yapici-Yavuz [52] DDwoR R+A CS R * Yapici-Yavuz [52] DDwoR R+A HA R * Yapici-Yavuz [52] DDwoR R+A Tenoxicam R * Ozdamar [53] ID R+A HA R * Gorrela [54] DDwR, DDwoR R+A HA R * Gurung [55] OA R+A HA R * Cömert Kiliç [56] OA R+A CS R * Patel [57] ID R+A HA R * Bouloux [58,59] P R+A CS R * Bouloux [58,59] P R+A HA R * Cömert Kiliç [60] OA R+A PRP R+HA * Korkmaz [61] DDwR A HA Splint therapy * Lam [62] P A Dextrose+Lidocaine Lidocaine * Cömert Kiliç [63] OA R+A PRP R * Hegab [64] OA A HA PRP * Hegab [64] OA A PRP HA * In line with the assumptions ...…”

“…These include, first of all, the blood products already discussed. Apart from them, there are the first experimental and clinical studies on intra-articular administration of adipose tissue and bone marrow cells [39,45,[93][94][95]. The promising results of these therapies do not exempt them from caution in their implementation [39,45].…”

Autologous Stem Cells Transplants in the Treatment of Temporomandibular Joints Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

“…The severity of joint pain decreased during the follow-up after the intervention. The data that were needed for this synthesis were provided by the reports by Carboni et al, De Riu et al, and Sembronio et al, whose results appear to be similar [ 55 , 57 , 75 ]. For the De Riu study, the severity of pain in motion was taken into account as Sembronio et al used similar measurement conditions [ 57 , 75 ].…”

Osteoarthritis year in review 2021: epidemiology & therapy

“…In our search from the last year, we found 6 new reviews but only 3 new small RCTs (n ¼ 40, 47 and 60) comparing an injected stem cell therapy intervention against active control intervention 27e29 . Two of these studies 28,29 , in patients with knee and temporomandibular joint OA, estimated between-group differences in pain at 6 months or beyond. In both instances these differences were not statistically significant.…”