2003
DOI: 10.1002/dvdy.10352
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Temporospatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development

Abstract: The gene expression and protein distribution of matrix metalloproteinase (MMP) -2, -9, membrane type-1 MMP (MT1-MMP), as well as of TIMP-1, -2, and -3 were analyzed during mouse molar development. Immunohistochemical data demonstrated that all the MMPs investigated were expressed in the dental epithelium and mesenchyme. In contrast, gene and protein expression analysis for TIMPs showed that they were differentially expressed. TIMP-1 was expressed in the dental epithelium and mesenchyme between E13 and E16 and … Show more

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Cited by 38 publications
(58 citation statements)
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“…5, third column). The alligator dl MMP14 expression pattern in the present study is similar to that seen in mouse molar development (Yoshiba et al 2003). MMP20 is faintly expressed in bud-stage and cap-stage samples.…”
Section: Sish Of Candidate Moleculessupporting
confidence: 85%
“…5, third column). The alligator dl MMP14 expression pattern in the present study is similar to that seen in mouse molar development (Yoshiba et al 2003). MMP20 is faintly expressed in bud-stage and cap-stage samples.…”
Section: Sish Of Candidate Moleculessupporting
confidence: 85%
“…We assume that MMPs and TIMPs are highly expressed in two key moments that modify caries susceptibility. First, these genes participate in enamel formation, in histomorphogenesis and cytodifferentiation [Yoshiba et al, 2003]. Both events are accompanied by changes in cellular organization and remodeling of the ECM [Yoshiba et al, 2003].…”
Section: Discussionmentioning
confidence: 99%
“…MMP13 is involved in bone development and repair [Yamagiwa et al, 1999;Inada et al, 2004] and is expressed in pulp dental tissue [Sulkala et al, 2004]. TIMP2 was detected in enamel matrix [Yoshiba et al, 2003] and is coexpressed with MMP2 and MMP9 during mouse tooth morphogenesis [Sahlberg et al, 1999]. TIMP2 is also an endogenous inhibitor of MMP13 [Knauper et al, 1996].…”
mentioning
confidence: 99%
“…47,50 Type 4 collagen is present in the dental basement membrane during the bud to cap stage of tooth development but disappears at later stages because of the MMP action 51,52 ; one of these proteinases is gelatinase A (MMP-2), whose expression has been correlated with collagen 4 and extracellular matrix degradation during the early stages of tooth development and specifically when epithelial cells migrate into the underlying mesenchyme, inducing and maintaining cell polarity and differentiation. 49,53,54 In our experiments, type 4 collagen was expressed only in the inner half of the intermediate layer and seemed to demarcate the future dentin enamel junction. At the same time, MMP-2, which is involved in type 4 collagen degradation, is coexpressed with type 4 collagen, correlating with the presence of a basement membrane under rearrangement, which modulates dental morphogenesis.…”
Section: Discussionmentioning
confidence: 45%
“…At the same time, MMP-2, which is involved in type 4 collagen degradation, is coexpressed with type 4 collagen, correlating with the presence of a basement membrane under rearrangement, which modulates dental morphogenesis. 54 Ameloblastic and odontoblastic markers are highly expressed in the intermediate inner layers.…”
Section: Discussionmentioning
confidence: 99%